Intestinal hemorrhages in patients with a nonseminomatous testicular tumor

Plukker, John; Koops, H. Schraffordt; Sleijfer, Dt; Oosterhuis, J. Wolter; Vanderjagt, E

doi:10.1002/1097-0142(19911215)68:12<2630::aid-cncr2820681220>3.0.co;2-w

Cited by 20 publications

(5 citation statements)

References 8 publications

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“…Gastrointestinal bleeding from site of metastasis following chemotherapy has also been reported [ 4 – 6 ]. Mechanisms include GI perforation following chemotherapy-induced tumor necrosis and shrinking of metastatic gastrointestinal tumor following chemotherapy [ 7 ]. Other chemotherapy-related complications involving the GI tract include cases of neutropenic colitis following salvage therapy for refractory nonseminomatous GCT of the testis [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review

Shogbesan

Abdulkareem

Jehangir

et al. 2017

Case Reports in Gastrointestinal Medicine

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Testicular germ cell tumors (GCT) are the commonest solid tumors in young men. Typical presentation is with painless scrotal swelling; however, symptoms related to complications or metastasis may be the initial presentation. Gastrointestinal (GI) metastasis is seen in about 5% of patients with germ cell tumors and presentation is commonly with GI bleed. It is important to have GCT as a differential diagnosis of GI bleed in young men presenting with unexplained anemia as direct questioning about scrotal swelling and genital examination when appropriate will guide further investigation and facilitate prompt diagnosis. We present a case of a 26-year-old man with testicular germ cell tumor and severe anemia secondary to extension and perforation of duodenum by retroperitoneal metastasis and a review of the literature on the gastrointestinal manifestations of testicular germ cell tumors.

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review

Shogbesan

Abdulkareem

Jehangir

et al. 2017

Case Reports in Gastrointestinal Medicine

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“…This is why the testicular mass was not discovered. Majority of testicular tumors present as non-painful masses [9] , [10] . Metastatic germ cell testicular tumor should be included in the differential diagnosis of GIT tumors in young men [11] .…”

Section: Discussionmentioning

confidence: 99%

Testicular seminoma metastasis to duodenum. Misdiagnosed as primary duodenal tumor

Ani

2016

International Journal of Surgery Case Reports

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HighlightsTesticular cancers are the most common malignancies in men aged 15–35 years.Testicular malignancies rarely metastasize to retroperitoneum and involve upper gastrointestinal tract.Testicular cancers may cause upper gastrointestinal tract complications, including: ulceration of bowel mucosa, hemorrhage and intestinal obstruction.Radical orchiectomy, followed by chemo-radiotherapy is the standard treatment of testicular malignancies.

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“…Rarely, NSGCTs can also involve the gastrointestinal tract, resulting in intestinal obstruction, gastrointestinal hemorrhage, and occasionally ulceration of the bowel mucosa [6][7][8][9]. However, each of these published reports consisted of metastatic seminomatous or mixed NSGCTs.…”

Section: Discussionmentioning

confidence: 99%

Novel Case of Metastatic Testicular Immature Teratoma Invading the Duodenum

Johnson¹,

Osunkoya²,

Delman³

et al. 2009

TOSOJ

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Abstract:We present the first report of an immature teratoma arising from a germ cell testicular cancer invading the duodenum. While other seminomatous and non-seminomatous germ cell tumors are known to metastasize to the duodenum, this is the first such case involving an immature teratoma directly invading the duodenum from a metastatic retroperitoneal mass.Keywords: Testis cancer, teratoma, duodenum. CASE REPORTA 26-year-old male underwent radical inguinal orchiectomy at an outside facility for a pT1 Nx Mx mixed nonseminomatous germ cell tumor (65% mature teratoma, 30% yolk sac, 15% embryonal). Preoperative tumor markers showed ( -fetoprotein (AFP), 2096 ng/mL and -Human chorionic gonadotropin (B-HCG), 139 mIU/ml). Postoperative tumor markers normalized AFP 3.6 ng/mL and B-HCG <2 mIU/ml) and CT scans of the chest and abdomen showed no signs of metastasis. Eighteen months later, the patient presented to our facility with progressive nausea and vomiting. Abdominal CT scan ( Fig. 1) and CT-guided biopsy revealed a 9.4 cm retroperitoneal tumor consistent with teratomatous elements of a mixed germ cell tumor. The duodenum proximal to the mass was dilated, indicating an element of obstruction. In retrospect, there was discontinuity of the duodenal wall indicating possible invasion by the mass (Fig. 1). Four months later, following four cycles of etoposide and cisplatin, the tumor shrunk to 5.8 cm. At this point, there were punctuate calcifications within the mass; the mass remained intimately associated with the anterior aorta and the undersurface of the third portion of the duodenum with interval clinical relief of the duodenal obstruction (Fig. 2). The patient's tumor markers remained within normal limits (AFP, <5 ng/mL and B-HCG, <1 mIU/ml). The patient underwent a retroperitoneal lymph node dissection and mass removal. Intraoperatively, the mass was easily dissected off the aorta and inferior vena cava but was found to be directly invading the duodenum, requiring resection of a portion of the duodenal wall to achieve negative surgical margins. Pathology revealed a mass consisting of 90% mature teratoma and 10% immature teratoma (Fig. 3), with invasion of the wall of duodenum, as confirmed by two subspeciality genitourinary pathologists. His clinical course was complicated by a readmission within the first 30 post-operative days, due to nausea and vomiting, *Address correspondence to this author at the Department of Urology, 1365 Clifton Road NE, Atlanta, GA 30322, USA; Tel: 404-778-3859; E-mail: vmaster@emory.edu Fig. (1). A, axial enhanced CT image and B, coronal enhanced CT reconstruction demonstrate invasion of the duodenum by metastatic adenopathy from testicular cancer. The duodenal wall (black arrows) is disrupted by tumor (white arrows).

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Intestinal hemorrhages in patients with a nonseminomatous testicular tumor

Cited by 20 publications

References 8 publications

Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review

Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review

Testicular seminoma metastasis to duodenum. Misdiagnosed as primary duodenal tumor

Novel Case of Metastatic Testicular Immature Teratoma Invading the Duodenum

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