Intestinal helminth coinfection is associated with mucosal lesions and poor response to therapy in American tegumentary leishmaniasis

Azeredo-Coutinho, Rilza Beatriz; Pimentel, Maria Inês Fernandes; Zaniní, Graziela Maria; Madeira, M.F.; Cataldo, Jamyra Iglesias; Schubach, Armando; Quintella, Leonardo Pereira; Mello, Cintia Xavier de; Mendonça, Sergio C. F.

doi:10.1016/j.actatropica.2015.10.015

Cited by 22 publications

(25 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These co-infected individuals also presented more therapeutic failures or relapses than patients not infected with helminths. These results suggest that intestinal infections with helminths interfere with the clinical course of tegumentary leishmaniasis (Azeredo-Coutinho et al, 2016). …”

Section: Introductionmentioning

confidence: 96%

“…This study shows that the early introduction of anthelmintic therapy does not improve clinical out-comes in patients coinfected with helminths and L. braziliensis (Newlove et al, 2011). A recent study showed that patients coinfected with intestinal helminths and Leishmania braziliensis had a higher frequency of tegumentary lesions and took longer to heal compared to patients without helminth infection (Azeredo-Coutinho et al, 2016). These co-infected individuals also presented more therapeutic failures or relapses than patients not infected with helminths.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Susceptibility of dendritic cells from individuals with schistosomiasis to infection by Leishmania braziliensis

Lopes

Almeida

Souza

et al. 2018

Molecular Immunology

View full text Add to dashboard Cite

Coinfection with leishmaniasis and schistosomiasis has been associated with increased time to healing of cutaneous lesions of leishmaniasis. The objective of this study was to evaluate the effect of Leishmania braziliensis infection on co-cultures of monocyte-derived dendritic cells (MoDCs) with autologous lymphocytes from patients with schistosomiasis and patients with cutaneous leishmaniasis. MoDCs were differentiated from peripheral blood monocytes, isolated by magnetic beads, infected with L. braziliensis, and co-cultured with autologous lymphocytes. Expression of HLA-DR, CD1a, CD83, CD80, CD86, CD40, and the IL-10 receptor (IL-10R) on MoDCs as well as CD28, CD40L, CD25, and CTLA-4 on lymphocytes were evaluated by flow cytometry. The production of the cytokines IL-10, TNF, IL-12p40, and IFN-γ were evaluated by sandwich ELISA of the culture supernatant. The infectivity evaluation was performed by light microscopy after concentration of cells by cytospin and Giemsa staining. It was observed that the frequency of MoDCs expressing CD83, CD80, and CD86 as well as the MFI of HLA-DR were smaller in the group of patients with schistosomiasis compared to the group of patients with leishmaniasis. On the other hand, the frequency of IL-10R on MoDCs was higher in patients with schistosomiasis than in patients with leishmaniasis. CD4+ and CD8+ T lymphocytes from patients with schis-tosomiasis presented a lower frequency of CD28 and a higher frequency of CTLA-4 compared to lymphocytes from patients with leishmaniasis. Levels of IL-10 were higher in the supernatants of co-cultures from individuals with schistosomiasis compared to those with leishmaniasis. However, levels of TNF, IL-12p40, and IFN-γ were lower in the group of individuals with schistosomiasis. Regarding the frequency of MoDCs infected by L. braziliensis after 72 h in culture, it was observed that higher frequencies of cells from patients with schistosomiasis were infected compared to cells from patients with leishmaniasis. It was concluded that MoDCs from patients with schistosomiasis are more likely to be infected by L. braziliensis, possibly due to a lower degree of activation and a regulatory profile.

show abstract

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Susceptibility of dendritic cells from individuals with schistosomiasis to infection by Leishmania braziliensis

Lopes

Almeida

Souza

et al. 2018

Molecular Immunology

View full text Add to dashboard Cite

show abstract

“…Later on, in the chronic phase, the type 2 response wanes and regulatory responses dominate . Studies on coinfection with intestinal helminths and Leishmania species are scarce, but concurrent intestinal helminth infection has in humans been associated with a shift in the immune response towards type 2 and increased severity of mucosal lesions caused by Leishmania brasiliensis . Data on how human worm infections affect the efficiency of anti‐leishmanial therapy are diverging .…”

Section: Introductionmentioning

confidence: 99%

“…Studies on coinfection with intestinal helminths and Leishmania species are scarce, but concurrent intestinal helminth infection has in humans been associated with a shift in the immune response towards type 2 and increased severity of mucosal lesions caused by Leishmania brasiliensis . Data on how human worm infections affect the efficiency of anti‐leishmanial therapy are diverging . We have previously shown that underlying infection with H polygyrus in mice causes higher hepatic load of the mycobacteria Bacillus Calmette‐Guérin (BCG) and facilitate L major propagation in the skin …”

Section: Introductionmentioning

confidence: 99%

“…coinfection, Heligmosomoides polygyrus, immune modulation, Leishmania spp, regulatory immunity, type 1 immunity, type 2 immunity caused by Leishmania brasiliensis. 10,11 Data on how human worm infections affect the efficiency of anti-leishmanial therapy are diverging. [10][11][12] We have previously shown that underlying infection with H polygyrus in mice causes higher hepatic load of the mycobacteria Bacillus Calmette-Guérin (BCG) and facilitate L major propagation in the skin.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intestinal nematode infection exacerbates experimental visceral leishmaniasis

Classon

Feng

Eidsmo

et al. 2019

Parasite Immunology

View full text Add to dashboard Cite

Summary Leishmania donovani exposure often results in subclinical infection in immunocompetent individuals, and the factors dictating development of visceral leishmaniasis (VL) are not known. Infection with intestinal worms skew immunity towards type 2 and regulatory responses, thereby theoretically increases susceptibility to intracellular infections controlled by type 1 responses. Here we have tested how chronic infection with the intestinal nematode Heligmosomoides polygyrus affected immunity to a secondary infection with L donovani. We found that mice infected with H polygyrus displayed higher Leishmania burden in liver and spleen compared to worm‐free animals. This increased infectious load was accompanied by reduced leucocyte infiltration and nos2 transcription in livers and increased il4 and il10 transcription in spleens. Collectively, these data show that chronic infection with intestinal nematodes skew immune responses in a way that may favour development of VL.

show abstract

Oral mucosal leishmaniasis presenting as a nonhealing chronic oral growth: A case report

Bajgai¹,

Tshering²,

Pradhan³

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Intestinal helminth coinfection is associated with mucosal lesions and poor response to therapy in American tegumentary leishmaniasis

Cited by 22 publications

References 64 publications

Susceptibility of dendritic cells from individuals with schistosomiasis to infection by Leishmania braziliensis

Susceptibility of dendritic cells from individuals with schistosomiasis to infection by Leishmania braziliensis

Intestinal nematode infection exacerbates experimental visceral leishmaniasis

Oral mucosal leishmaniasis presenting as a nonhealing chronic oral growth: A case report

Contact Info

Product

Resources

About