Intestinal fungal and parasitic infections in kidney transplant recipients: A multi-center study

Naeini, Afsoon Emami; Sharifi, Mehran; Shahidi, Shahrzad; Taheri, Shahram; Seirafian, Shiva; Taheri, Dyana; Tazhibi, Mahdi; Hejazi, Seyed Hossein; Naini, Pardis Emami; Harandi, Asghar Amini

doi:10.4103/1319-2442.98110

Cited by 16 publications

(15 citation statements)

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“…A wide range of fungi such as Candida albicans , Candida non albicans ( Candida tropicalis , C. parapsilosis , C. rugosa , C. guilliermondii, C. lusitaniae ), other yeast than Candida ( Geotrichum, Trichosporon , Rhodotorula , Rhizopus , Cryptococcus, Malassezia species) and filamentous fungi such as Penicillium and Aspergillus , have been commonly isolated from both healthy and hospitalized patients including immunosuppressed patients (Table ).…”

Section: Methods For Intestinal Fungal Detectionmentioning

confidence: 99%

Repertory of eukaryotes (eukaryome) in the human gastrointestinal tract: taxonomy and detection methods

Hamad

Raoult

Bittar

2015

Parasite Immunology

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Eukaryotes are an important component of the human gut, and their relationship with the human host varies from parasitic to commensal. Understanding the diversity of human intestinal eukaryotes has important significance for human health. In the past few decades, most of the multitudes of techniques that are involved in the diagnosis of the eukaryotic population in the human intestinal tract were confined to pathological and parasitological aspects that mainly rely on traditionally based methods. However, development of culture-independent molecular techniques comprised of direct DNA extraction from faeces followed by sequencing, offer new opportunities to estimate the occurrence of eukaryotes in the human gut by providing data on the entire eukaryotic community, particularly not-yet-cultured or fastidious organisms. Further broad surveys of the eukaryotic communities in the gut based on high throughput tools such as next generation sequencing might lead to uncovering the real diversity of these ubiquitous organisms in the human intestinal tract and discovering the unrecognized roles of these eukaryotes in modulating the host immune system and inducing changes in host gut physiology and ecosystem.

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Section: Methods For Intestinal Fungal Detectionmentioning

confidence: 99%

Repertory of eukaryotes (eukaryome) in the human gastrointestinal tract: taxonomy and detection methods

Hamad

Raoult

Bittar

2015

Parasite Immunology

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“…In other local studies on fungal infections in children with advanced kidney disease undergoing peritoneal dialysis 25 and adults with kidney transplantation, 26 the role of Candida spp. was shown to be dominant.…”

Section: Epidemiological Insights and The Treatment Rationalementioning

confidence: 99%

Invasive candidiasis in intensive care unit; consensus statement from an Iranian panel of experts, July 2013

et al. 2014

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Invasive candidiasis (IC) is associated with high mortality in intensive care unit (ICU) patients. Timely diagnosis of this potentially fatal condition remains a challenge; on the other hand, the criteria for initiating empirical antifungal therapy in critically ill patients are not well defined in different patient population and ICU settings. Alongside the international guidelines, reaching regional and local consensus on diagnosis and management of IC in ICU setting is essential. This report summarizes our present status of IC management in ICU, considered by a group of Iranian experts in the fields of intensive care and infectious diseases. A round table of 17 experts was held to review the available data and discuss the optimal treatment strategies for IC in critical care setting. Comparative published data on the management of IC were analytically reviewed and the commonly asked questions about the management of IC in ICU were isolated. These questions were interactively discussed by the panel and audience responses were taken to consolidate point-to-point agreement with the panel arriving at consensus in many instances. The responses indicated that patients’ risk stratification, clinical discretion, fungal diagnostic techniques and the empirical therapy for IC are likely to save more patients. Treatment options were recommended to be based on the disease severity, prior azole exposure, and the presence of suspected azole-resistant Candida species. This report was reviewed, edited and discussed by all participants to include further evidence-based insights. The panel expects such endorsed recommendations to be soon formulated for implementation across the country.

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“…Considering chronic renal failure as a possible indication for RT, parasitology studies in Brazil showed a positivity of 20.1% (Kulik et al, 2008) and 24.5% (Gil et al, 2013) for Blastocystis sp. In addition, Naeini et al (2012) reported 4.7% positivity for Blastocystis sp. in RT patients.…”

Section: Discussionmentioning

confidence: 99%

Subtypes of Blastocystis sp. isolated in fecal samples from transplant candidates in São Paulo, Brazil

Silva

Melo

Malta

et al. 2020

Parasite Epidemiology and Control

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Blastocystis sp. is an intestinal protozoan commonly found in fecal samples of many animal species, including humans, but poorly studied in transplant candidates. The aim of this study was to evaluate the occurrence and molecular identification of Blastocystis sp. in fecal samples from transplant candidates. A polymerase chain reaction was performed using specific primers for Blastocystis ribosomal DNA. The DNA sequences obtained were aligned and compared with other sequences from the GenBank and MLST databases. The analyzed samples showed a positivity of 16% (24 of 150) for Blastocystis sp. The highest occurrence was observed in renal transplant candidates (31.4%), followed by hepatic transplant candidates (10.4%) and candidates for bone marrow transplantation (5.9%). Subtype (ST) 3 (45.8%) was the most prevalent among the isolates, followed by ST1 (37.5%), ST2 (12.5%), and ST7 (4.2%). This is the first study of molecular identification Blastocystis sp. in transplant candidates. Our results confirmed that ST3 was the most common subtype in transplant candidates and reinforce the importance of new studies to investigate of Blastocystis sp. in these patients.

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Intestinal fungal and parasitic infections in kidney transplant recipients: A multi-center study

Cited by 16 publications

References 0 publications

Repertory of eukaryotes (eukaryome) in the human gastrointestinal tract: taxonomy and detection methods

Repertory of eukaryotes (eukaryome) in the human gastrointestinal tract: taxonomy and detection methods

Invasive candidiasis in intensive care unit; consensus statement from an Iranian panel of experts, July 2013

Subtypes of Blastocystis sp. isolated in fecal samples from transplant candidates in São Paulo, Brazil

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