Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease

Kirschner, Sarah; Deutz, N.E.P.; Jonker, Renate; Damink, Steven W. M. Olde; Harrykissoon, R.; Zachria, Anthony J.; Dasarathy, Srinivasan; Engelen, M.P.

doi:10.1016/j.clnu.2020.10.010

Cited by 22 publications

(36 citation statements)

References 36 publications

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“…The urinary recoveries of lactulose, rhamnose, and 3‐OMG were corrected for individual baseline sugar concentrations and standardized for oral intake. Small‐intestinal paracellular permeability was measured as the lactulose/rhamnose ratio and active carrier‐mediated transcellular glucose transport as the urinary 3‐OMG recovery rate (%) 16,18 …”

Section: Methodsmentioning

confidence: 99%

“…16 Protein digestion and absorption were measured by stable tracer kinetics as previously described. 16,18 In short, a catheter was inserted into a superficial vein of the lower arm, and the hand was placed into a thermostatically controlled hot box (internal temperature: 50 • C) for arterialized-venous blood sampling. 19 Baseline blood samples were drawn to determine natural Phe enrichments.…”

Section: Intestinal Function and Clinical Measurementsmentioning

confidence: 99%

“…Plasma concentrations of the SCFAs acetate, propionate, butyrate, isovalerate, and valerate were determined in baseline plasma samples. 18,23 Body composition and muscle health We calculated body mass index (BMI) after measuring body weight and height. 19 We measured total fat mass, fat-free mass, lean body mass, and appendicular skeletal muscle mass (sum of muscle mass in legs and arms) by dual-energy x-ray absorptiometry and standardized these for height.…”

Section: Intestinal Function and Clinical Measurementsmentioning

confidence: 99%

“…Urine aliquots were stored at −80 • C, and lactulose, rhamnose, and 3-OMG concentrations were analyzed by high-pressure liquid mass spectrometry. 18 We sampled arterialized-venous blood into Li-heparinized and EDTA tubes (SARSTEDT, Nümbrecht, Germany), which were immediately stored on ice and centrifuged to separate plasma (4 • C, 8000g for 5 min). For deproteinization, Li-heparinized plasma was aliquoted into tubes containing 0.1 vol of 33% (wt/wt) trichloroacetic acid and vortexed.…”

Section: Biochemical Analysismentioning

confidence: 99%

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Impaired intestinal function is associated with lower muscle and cognitive health and well‐being in patients with congestive heart failure

Kirschner¹,

Deutz²,

Rijnaarts³

et al. 2021

J Parenter Enteral Nutr

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Background Small‐ and large‐intestinal perturbations have been described as prevalent extracardiac systemic manifestations in congestive heart failure (CHF), but alterations in protein digestion and absorption and plasma short‐chain fatty acid (SCFA) concentrations and the potential link with other systemic effects (muscle and cognitive health) have not been investigated in CHF. Methods We analyzed protein digestion and absorption with dual stable tracer method in 14 clinically stable, noncachectic CHF outpatients (mean left ventricular ejection fraction: 35.5% [95% CI, 30.9%–40.1%]) and 15 controls. Small‐intestinal non–carrier‐mediated permeability and active carrier‐mediated glucose transport were quantified by sugar permeability test. Plasma SCFA (acetate, propionate, butyrate, isovalerate, valerate) concentrations were measured as intestinal microbial metabolites. Muscle function was assessed by isokinetic dynamometry, cognition by a battery of tests, and well‐being by questionnaire. Results Protein digestion and absorption were impaired by 29.2% (P = .001) and active glucose transport by 38.4% (P = .010) in CHF. Non–carrier‐mediated permeability was not altered. Whereas plasma propionate, butyrate, and isovalerate concentrations were lower in CHF (P < .05), acetate and valerate concentrations did not differ. Overall, intestinal dysfunction was associated with impaired leg muscle quality, emotional distress, and cognitive dysfunction (P < .05). Conclusions We identified impaired protein digestion and absorption and altered SCFA concentrations as additional intestinal dysfunctions in CHF that are linked to reduced muscle and cognitive health and well‐being. More research is needed to implement strategies to improve intestinal function in CHF and to investigate the mechanisms underlying its link with other systemic manifestations.

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Section: Methodsmentioning

confidence: 99%

Section: Intestinal Function and Clinical Measurementsmentioning

confidence: 99%

Section: Intestinal Function and Clinical Measurementsmentioning

confidence: 99%

Section: Biochemical Analysismentioning

confidence: 99%

See 2 more Smart Citations

Impaired intestinal function is associated with lower muscle and cognitive health and well‐being in patients with congestive heart failure

Kirschner¹,

Deutz²,

Rijnaarts³

et al. 2021

J Parenter Enteral Nutr

Self Cite

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“…It has been demonstrated that intestinal dysfunction is present in COPD, worsens with increasing disease severity and is associated with reduced quality of life. 7 In addition, individuals with COPD have functional and structural alterations in their intestinal mucosa, and patients with COPD typically have increased intestinal permeability. 8–10 Increasing evidence has indicated the intimate relationship between the gastrointestinal tract and respiratory tract.…”

Section: Introductionmentioning

confidence: 99%

Prediction of exacerbation frequency of AECOPD based on next-generation sequencing and its relationship with imbalance of lung and gut microbiota: a protocol of a prospective cohort study

Deng

Yan

et al. 2021

BMJ Open

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IntroductionPatients with frequent acute exacerbation phenotype chronic obstructive pulmonary disease (AECOPD) have a higher hospitalisation rate than infrequent exacerbation, the disease progresses quickly and treatment is more difficult. At present, it is impossible to predict patients with COPD with frequent acute exacerbation phenotypes. The composition of the lower respiratory tract flora and the intestinal flora is closely related to AECOPD, but the specific association mechanism between them is not very clear. This study used metagenomic next-generation sequencing (mNGS) technology to explore the microbial characteristics of the intestinal tract and airways of patients with COPD, and analyse the correlation between the sequencing results and inflammatory factors, immune factors and nutritional factors.Methods and analysisThis will be a prospective cohort study. We intend to recruit 152 patients with stable COPD. In the baseline, we will detect the participants’ induced sputum and faecal flora through mNGS, and changes in blood immune levels, and the patient’s condition is evaluated. Every 2 months, we will check the number of acute exacerbation through the phone range. After 12 months, we will check again the changes in the blood immune level, evaluate the patient’s condition and count the number of episodes.Ethics and disseminationThis study has been approved by the ethics committee of Guangdong Provincial Hospital of Traditional Chinese Medicine (approval number ZF2019-219-03). The results of the study will be published in peer-reviewed journals.Trial registration numberClinicalTrials.gov Registry (ChiCTR2000032870).

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Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

Yang,

Zhang,

Wang

et al. 2024

iMeta

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The gut microbiota is a complex community of microorganisms inhabiting the intestinal tract, which plays a vital role in human health. It is intricately involved in the metabolism, and it also affects diverse physiological processes. The gut–lung axis is a bidirectional pathway between the gastrointestinal tract and the lungs. Recent research has shown that the gut microbiome plays a crucial role in immune response regulation in the lungs and the development of lung diseases. In this review, we present the interrelated factors concerning gut microbiota and the associated metabolites in pulmonary hypertension (PH), a lethal disease characterized by elevated pulmonary vascular pressure and resistance. Our research team explored the role of gut‐microbiota‐derived metabolites in cardiovascular diseases and established the correlation between metabolites such as putrescine, succinate, trimethylamine N‐oxide (TMAO), and N, N, N‐trimethyl‐5‐aminovaleric acid with the diseases. Furthermore, we found that specific metabolites, such as TMAO and betaine, have significant clinical value in PH, suggesting their potential as biomarkers in disease management. In detailing the interplay between the gut microbiota, their metabolites, and PH, we underscored the potential therapeutic approaches modulating this microbiota. Ultimately, we endeavor to alleviate the substantial socioeconomic burden associated with this disease. This review presents a unique exploratory analysis of the link between gut microbiota and PH, intending to propel further investigations in the gut–lung axis.

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Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease

Cited by 22 publications

References 36 publications

Impaired intestinal function is associated with lower muscle and cognitive health and well‐being in patients with congestive heart failure

Impaired intestinal function is associated with lower muscle and cognitive health and well‐being in patients with congestive heart failure

Prediction of exacerbation frequency of AECOPD based on next-generation sequencing and its relationship with imbalance of lung and gut microbiota: a protocol of a prospective cohort study

Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

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