Intestinal Function and Morphology in Strongyloidiasis *

García, Fernando; Sessions, John T.; Strum, Williamson B.; Schweistris, E.; Tripathy, Kshetrabasi; Bolaños, Óscar; Lotero, H; Duque, Edgar; Ramelli, D.; Mayoral, Luis Guillermo

doi:10.4269/ajtmh.1977.26.859

Cited by 28 publications

(12 citation statements)

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“…been described in strongyloidiasis (41) and it is possible that the little time for contact between EDTA and the intestinal mucosa affected permeation by the marker. However, this assumption must be evaluated with caution in view of a recent report stating that small intestinal transit has no influence on the excretion of 51 Cr-EDTA, at least in healthy individuals (42).…”

Section: Discussionmentioning

confidence: 99%

Intestinal permeability in strongyloidiasis

Werneck-Silva

Sipahi

Damião

et al. 2001

Braz J Med Biol Res

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The objective of the present study was to assess intestinal permeability in patients with infection caused by Strongyloides stercoralis. Twentysix patients (16 women and 10 men), mean age 45.9, with a diagnosis of strongyloidiasis were evaluated. For comparison, 25 healthy volunteers (18 women and 7 men), mean age 44.9, without digestive disorders or intestinal parasites served as normal controls. Intestinal permeability was measured on the basis of urinary radioactivity levels during the 24 h following oral administration of chromium-labeled ethylenediaminetetraacetic acid ( 51 Cr-EDTA) expressed as percentage of the ingested dose. The urinary excretion of 51 Cr-EDTA was significantly reduced in patients with strongyloidiasis compared to controls (1.60 ± 0.74 and 3.10 ± 1.40, respectively, P = 0.0001). Intestinal permeability is diminished in strongyloidiasis. Abnormalities in mucus secretion and intestinal motility and loss of macromolecules could explain the impaired intestinal permeability.

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Section: Discussionmentioning

confidence: 99%

Intestinal permeability in strongyloidiasis

Werneck-Silva

Sipahi

Damião

et al. 2001

Braz J Med Biol Res

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“…Like other enteric parasitoses, strongyloidiasis has been classically regarded as the cause of a wide variety of gastrointestinal ailments, ranging from the ill-defined "dyspepsia" and "postprandial bloating" (3,14,20,81) to diarrhea and malabsorption (12,82), although the occurrence of malabsorption has been disputed by a carefully controlled study (38). More severe gastrointestinal presentations have been reported for some patients, including upper and lower intestinal bleeding (9,22), jejunal perforation (64), emphysematous gastritis (114), appendicitis (89), symptoms mimicking ulcerative colitis (8,13), granulomatous hepatitis (75,93), eosinophilic ascites (71), and profound electrolyte imbalance leading to cardiac arrest (63).…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of strongyloidiasis: a new hypothesis

Genta

1992

Clin Microbiol Rev

150

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Few other human parasites are associated with such a diverse spectrum of clinical manifestations as Strongyloides stercoralis, yet the basic biological behavior of this unusually versatile worm, particularly with respect to its ability to cause severe disseminated disease in certain hosts, is poorly understood. The current uncritical acceptance of the theory that cell-mediated immunity controls autoinfection has stifled research in other directions. After reviewing what is and is not known about the parasite's behavior in its host, this article explores some of the mechanisms that could be involved in the regulation of the parasite population. Taking the provocative viewpoint that the parasite, not the host, is mainly responsible for the maintenance of a balanced relationship between the two, I propose a new theory that corticosteroids may act on the intraintestinal larvae as molting hormones and directly promote the development of disseminated disease.

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Section: Reduced Gi Absorptionmentioning

confidence: 99%

“…Garcia et al investigated the malabsorption in patients with disseminatedstrongyloidiasis with or without malnutrition [163]. They found that treatment of the parasite using thiabendazole has eradicated the parasite but did not improve the GI absorption [163]. On the other hand, protein replenishment reversed the malnutrition state, improved GI-absorption even without treatment with thiabendazole to eradicate the parasite [163].…”

Section: Reduced Gi Absorptionmentioning

confidence: 99%

“…They found that treatment of the parasite using thiabendazole has eradicated the parasite but did not improve the GI absorption [163]. On the other hand, protein replenishment reversed the malnutrition state, improved GI-absorption even without treatment with thiabendazole to eradicate the parasite [163]. Moreover, they found that patients with disseminated strongyloidiasis that had good nutrition state, GI-absorption was not reduced even though their GI examination showed jejunum rigidity and lesions [163].…”

Section: Reduced Gi Absorptionmentioning

confidence: 99%

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Physiologically based pharmacokinetic (PBPK) model of Ivermectin (IVM)

Alsmadi¹

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Intestinal Function and Morphology in Strongyloidiasis *

Cited by 28 publications

References 0 publications

Intestinal permeability in strongyloidiasis

Intestinal permeability in strongyloidiasis

Dysregulation of strongyloidiasis: a new hypothesis

Physiologically based pharmacokinetic (PBPK) model of Ivermectin (IVM)

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