Intestinal Fluid and Glucose Transport in Wistar Rats following Chronic Consumption of Fresh or Oxidised Palm Oil Diet

Abstract

Chronic ingestion of thermoxidized palm oil causes functional derangement of various tissues. This study was therefore carried out to determine the effect of chronic ingestion of thermoxidized and fresh palm oil diets on intestinal fluid and glucose absorption in rats using the everted sac technique. Thirty Wistar rats were divided into three groups of 10 rats per group. The first group was the control and was fed on normal rat chow while the second (FPO) and third groups (TPO) were fed diet containing either fresh or thermoxidized palm oil (15% wt/wt) for 14 weeks. Villus height and crypt depth were measured. The gut fluid uptake and gut glucose uptake were significantly (P < .001) lower in the TPO group than those in the FPO and control groups, respectively. The villus height in the TPO was significantly (P < .01) lower than that in FPO and control. The villus depth in TPO was significantly (P < .05) higher than that in FPO and control groups, respectively. These results suggest that ingestion of thermoxidized palm oil and not fresh palm oil may lead to distortion in villus morphology with a concomitant malabsorption of fluid and glucose in rats due to its harmful free radicals.

Comparative analysis on the effect of palm oil (Elaeis guineensis) in reducing cadmium and lead accumulation in liver of Wistar rats

“…We had earlier reported that oil from palm significantly reduced the GOT and GPT increase in the liver induced by exposures to heavy metal,[828] the study then suggests that the oil from palm has a hepatoprotective role as has been highlighted by some researchers. [829]…”

Ameliorative Effects of Pomegranate Peel Extract against Dietary-Induced Nonalcoholic Fatty Liver in Rats

“…Recent in vivo , in vitro , and epidemiological studies have shown few medicinal properties of PPE as an antioxidant, against colon cancer, T2DM, and inflammatory-mediated diseases ( 21 – 25 ). Also, PPE possesses radical-scavenging properties in diethylnitrosamine-induced liver injuries, reversed methotrexate toxicity in the liver by decreasing oxidative stress and liver apoptosis, and enhanced the activity of liver enzymes against ROS after CCl 4 toxicity ( 26 , 27 ). This study aims to explore the potential role of PPE in HFD-fed rats.…”

Repeatedly Heated Vegetable Oils and Lipid Peroxidation

“…It was shown to demonstrate genotoxic and preneoplastic change in the rat liver [10]. It also impaired fluid and glucose intestinal absorption in rats [11]. In rats given alcohol plus heated sunflower, an apparent liver damage as well as increased cholesterol level was observed [12].…”