Intestinal flora in very low‐birth weight infants

Björkström, Markus V.; Hall, Lina; Söderlund, Stina; Håkansson, Eva Grahn; Håkansson, Stellan; Domellöf, Magnus

doi:10.1111/j.1651-2227.2009.01471.x

Cited by 57 publications

(44 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In agreement with previous studies of preterm infants 12 , this study showed early, predominant colonization with potentially pathogenic bacteria. A recent study showed that the prolonged period prior to full enteral feeding could explain this finding 13 .…”

Section: Discussionsupporting

confidence: 93%

Late onset sepsis and intestinal bacterial colonization in very low birth weight infants receiving long-term parenteral nutrition

Fernandes

Dolinger

Abdallah

et al. 2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction:The purpose of this study was to establish the late onset sepsis (LOS) rate of our service, characterize the intestinal microbiota and evaluate a possible association between gut flora and sepsis in surgical infants who were receiving parenteral nutrition (PN). Methods: Surveillance cultures of the gut were taken at the start of PN and thereafter once a week. Specimens for blood culture were collected based on clinical criteria established by the medical staff. The central venous catheter (CVC) tip was removed under aseptic conditions. Standard laboratory methods were used to identify the microorganisms that grew on cultures of gut, blood and CVC tip. Results: 74 very low birth weight infants were analyzed. All the infants were receiving PN and antibiotics when the gut culture was started. In total, 21 (28.4%) infants experienced 28 episodes of LOS with no identified source. Coagulase negative staphylococci were the most common bacteria identified, both in the intestine (74.2%) and blood (67.8%). All infections occurred in patients who received PN through a central venous catheter. Six infants experienced episodes of microbial translocation. Conclusions: In this study, LOS was the most frequent episode in neonates receiving parenteral nutrition who had been submitted to surgery; 28.6% of this infection was probably a gut-derived phenomenon and requires novel strategies for prevention.

show abstract

Section: Discussionsupporting

confidence: 93%

Late onset sepsis and intestinal bacterial colonization in very low birth weight infants receiving long-term parenteral nutrition

Fernandes

Dolinger

Abdallah

et al. 2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…Unfortunately, this undertaking seemed futile due to high intra- and interindividual variations and a large number of factors influencing fCP expression, particularly during the first week of life. Moreover, even though previous studies, both case-control and prospective cohort studies, have identified trends in fCP levels and correlations with intestinal illness, some are limited by sample size and others by sparse sampling unrelated to timing of events relative to sample acquisition [15,16,17,18]. Since developmental changes in intestinal innate and adaptive immunity most likely contribute to the GA variation in NEC risk [19], studies of larger sample size allowing for assessment of GA influence on fCP would be highly informative.…”

Section: Introductionmentioning

confidence: 99%

Fecal Calprotectin Concentrations in Premature Infants Have a Lower Limit and Show Postnatal and Gestational Age Dependence

Zoppelli¹,

Güttel²,

Bittrich³

et al. 2012

Neonatology

View full text Add to dashboard Cite

Background: There is a need for reliable diagnostic biomarkers in necrotizing enterocolitis (NEC). Whereas fecal calprotectin (fCP) has been reported to have insufficient sensitivity and specificity, no previous study has stratified for gestational and postnatal age. Objective: We aimed to provide developmental specific fCP data in premature infants and to analyze its value in detecting intestinal distress and episodes of NEC. Methods: Between April 2008 and December 2009, 1,899 fecal samples were obtained from 206 very low birth weight infants. Results: Mean gestational age (GA) was 28.5 weeks and birth weight 1,057 g. 19 (9.2%) patients developed NEC stage II+, of whom 5 had fulminant NEC with unusually low fCP concentrations in meconium and afterwards. fCP levels showed significant gestational and postnatal age dependent dynamics with particularly low levels in extremely premature infants. In infants with a GA <26 + 1 weeks using GA-adapted reference values, the sensitivity for discriminating moderate NEC from healthy infants and infants with intestinal distress was 0.89 for a cut-off of 180 and 210 µg/g, respectively, at onset of symptoms. Specificity was 0.96 and 0.84. Fulminant NEC was characterized by unusually low fCP concentrations with a cut-off of <24 µg/g having a sensitivity of 0.84 and a specificity of 0.72 for identifying those cases. Conclusions: fCP levels depend on gestational and postnatal age and in contrast to adults, there is a lower limit in premature infants. Taking these observations into account when defining reference values and interpreting fCP data in the clinical context, fCP can be a useful marker in identifying premature infants with gastrointestinal distress and NEC in particular.

show abstract

“…0%, within the first week of life without oral administration of probiotics. 23 Jacquot et al reported that the most common bacteria in stool specimens found at 3 -4 weeks postnatally was Clostridium. 24 The same study showed that Enterobacteriaceae accounted for less than < 10% and 44.4% in stool cultures at 6 and 8 weeks of life, respectively, and Bifidobacterium was < 10% at 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

Effect of oral administration of probiotics on intestinal colonization with drug-resistant bacteria in preterm infants

Kurt

Ince

Ecevit

et al. 2017

View full text Add to dashboard Cite

show abstract

Intestinal flora in very low‐birth weight infants

Abstract: In contrast to the previous studies in VLBW infants, we found an early colonization with LAB. We speculate that this may be due to early feeding of non-pasteurized breast milk.

Cited by 57 publications

References 24 publications

Late onset sepsis and intestinal bacterial colonization in very low birth weight infants receiving long-term parenteral nutrition

Late onset sepsis and intestinal bacterial colonization in very low birth weight infants receiving long-term parenteral nutrition

Fecal Calprotectin Concentrations in Premature Infants Have a Lower Limit and Show Postnatal and Gestational Age Dependence

Effect of oral administration of probiotics on intestinal colonization with drug-resistant bacteria in preterm infants

Contact Info

Product

Resources

About