Intestinal fine structure in crohn's disease

Microvilli‐ and Desmosome‐Associated Bodies in Crohn's Disease and Other Disorders in Childhood

“…Ultras tructural studies in Croh ns disease have largely examined intestin al tissues from adult patient s with severe disease (12)(13)(14)(15)(16). None of these studies ha s describ ed abnormalities similar to MD bodies , and mo st have noted the abse nce of microbial agents (12 ,13), altho ugh there are some exception s. Aluwihare (15) demon strat ed the presence of intramural bacteria and co nside red that these may have some aetiological significa nce .…”

“…None of these studies ha s describ ed abnormalities similar to MD bodies , and mo st have noted the abse nce of microbial agents (12 ,13), altho ugh there are some exception s. Aluwihare (15) demon strat ed the presence of intramural bacteria and co nside red that these may have some aetiological significa nce . Reimann (16) repo rted the presence of virus-like particles of 30-70 nm in diameter in gut epithelial cells and macrophages, and Th yberg et al (14) also des cribed virus -like particles of 40-60 nm in diameter in epi- theli al cells in Cr ohu ' s disease. The particles illustrated by Thyberg et al (14), however , resemble the R-bodies of no r mal hu m an rectum (17) in bo t h stru ctur e and size .…”

“…Reimann (16) repo rted the presence of virus-like particles of 30-70 nm in diameter in gut epithelial cells and macrophages, and Th yberg et al (14) also des cribed virus -like particles of 40-60 nm in diameter in epi- theli al cells in Cr ohu ' s disease. The particles illustrated by Thyberg et al (14), however , resemble the R-bodies of no r mal hu m an rectum (17) in bo t h stru ctur e and size . Dourmashkin and colleagues (18-20) de scribed a phe nomenon in Crohri' s disease in which part icles were produced by budding from microvilli or from the lumin al membranes of enterocy tes show ing microvillous loss.…”

Ultrastructural changes in chronic inflammatory enteropathies—a comparison between dogs and humans

“…• Extracellular edema with marked infiltrates of inflammatory cells (Ranlov et al, 1972;Thyberg et al, 1981;Brewer et al, 1990) • Marked infiltrates of inflammatory cells (Delpre et al, 1989;Brewer et al, 1990) • Activated fibroblasts and extracellular fibrin deposition (Ranlov et al, 1972) • Lymphatics…”

The Effect of Zinc Therapy on Lysosomal Inclusion Bodies in Intestinal Epithelial Cells in Acrodermatitis Enteropathica

“…Lysosomal inclusion bodies have been described in the apical cytoplasm of small intestinal epithelial cells in / 3 lipoprotein deficiency (6), coeliac disease (14), tropical sprue (12), infantile malnutrition (5), Crohn's disease (15), and after aspirin ingestion (9). It has been suggested that these inclusion bodies are autophagosomes, bacteria or dead epithelial cells ingested by their neighbours.…”