Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke

Mani, Kathiresh Kumar; El-Hakim, Yumna; Branyan, Taylor; Samiya, Nadia; Pandey, Sivani; Grimaldo, Maria T.; Habbal, Ali; Wertz, Anna; Sohrabji, Farida

doi:10.1016/j.bbi.2022.10.015

Cited by 18 publications

(11 citation statements)

References 77 publications

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“…Stem cell therapy and organoid techniques are novel strategies for gut remediation (Shaker and Rubin, 2012). Mani et al (2023) showed that the gut is a critical therapeutic target for stroke. They engrafted organoids containing intestinal epithelial stem cells (IESCs) from young rats into older model rats that suffered a stroke.…”

Section: Tcm Prescriptionmentioning

confidence: 99%

“…In the past two decades, more than 1,000 potential neuroprotectants have been found to attenuate ischemic brain injury by promoting neuronal survival, neural plasticity, neurogenesis, and synaptogenesis (Liberale et al, 2018;Shen et al, 2023). However, the studies were mainly conducted on experimental IS animal models, and only a few agents targeting these molecules could be administered in the clinic (Gauberti et al, 2018;Gan et al, 2020;Mani et al, 2023). Stem cell therapy and neural progenitor cell transplantation therapy provide a regenerative strategy for protecting neural tissue in the acute phase and the replacement of lost tissues in the sub-acute or chronic phase of IS (Wei et al, 2017;Yu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Stem cell therapy and neural progenitor cell transplantation therapy provide a regenerative strategy for protecting neural tissue in the acute phase and the replacement of lost tissues in the sub-acute or chronic phase of IS (Wei et al, 2017;Yu et al, 2019). However, this technique has numerous challenges, including identifying suitable neural progenitors, low overall survival of the neurons, and insufficient neuronal differentiation (Wei et al, 2017;Wang S. N. et al, 2020;Mani et al, 2023). Thus, the technique needs to be further improved before clinical application.…”

Section: Introductionmentioning

confidence: 99%

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Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

Wang

Liu

2023

Front. Neurosci.

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The microbiota-gut-brain axis connects the brain and the gut in a bidirectional manner. The organism’s homeostasis is disrupted during an ischemic stroke (IS). Cerebral ischemia affects the intestinal flora and microbiota metabolites. Microbiome dysbiosis, on the other hand, exacerbates the severity of IS outcomes by inducing systemic inflammation. Some studies have recently provided novel insights into the pathogenesis, efficacy, prognosis, and treatment-related adverse events of the gut microbiome in IS. In this review, we discussed the view that the gut microbiome is of clinical value in personalized therapeutic regimens for IS. Based on recent non-clinical and clinical studies on stroke, we discussed new therapeutic strategies that might be developed by modulating gut bacterial flora. These strategies include dietary intervention, fecal microbiota transplantation, probiotics, antibiotics, traditional Chinese medication, and gut-derived stem cell transplantation. Although the gut microbiota-targeted intervention is optimistic, some issues need to be addressed before clinical translation. These issues include a deeper understanding of the potential underlying mechanisms, conducting larger longitudinal cohort studies on the gut microbiome and host responses with multiple layers of data, developing standardized protocols for conducting and reporting clinical analyses, and performing a clinical assessment of multiple large-scale IS cohorts. In this review, we presented certain opportunities and challenges that might be considered for developing effective strategies by manipulating the gut microbiome to improve the treatment and prevention of ischemic stroke.

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Section: Tcm Prescriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

Wang

Liu

2023

Front. Neurosci.

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“…In a rat model, adult PAE animals experience worse acute stroke outcomes and impaired long-term recovery following an ischemic stroke, with evidence for increased gut permeability following stroke (Bake et al, 2022). Recent work has shown that gut health is an important therapeutic focus for stroke recovery, as intestinal epithelial stem cell transplant has been shown to improve both acute and long-term recovery following ischemic stroke in a rat model (Mani et al, 2023). Therefore, early interventions targeting microbiota could lead to improvements not only in neurodevelopment, but health across the lifespan following PAE.…”

Section: Microbial Contribution To Risks For Later-in-life Health Out...mentioning

confidence: 99%

Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure

Upreti,

Rouzer,

Bowring

et al. 2023

Front. Neurosci.

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Alcohol exposure in adulthood can result in inflammation, malnutrition, and altered gastroenteric microbiota, which may disrupt efficient nutrient extraction. Clinical and preclinical studies have documented convincingly that prenatal alcohol exposure (PAE) also results in persistent inflammation and nutrition deficiencies, though research on the impact of PAE on the enteric microbiota is in its infancy. Importantly, other neurodevelopmental disorders, including autism spectrum and attention deficit/hyperactivity disorders, have been linked to gut microbiota dysbiosis. The combined evidence from alcohol exposure in adulthood and from other neurodevelopmental disorders supports the hypothesis that gut microbiota dysbiosis is likely an etiological feature that contributes to negative developmental, including neurodevelopmental, consequences of PAE and results in fetal alcohol spectrum disorders. Here, we highlight published data that support a role for gut microbiota in healthy development and explore the implication of these studies for the role of altered microbiota in the lifelong health consequences of PAE.

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“…3 Stroke as a severe cerebrovascular event is a health burden on families and society. 4 Despite the advanced treatment available for stroke patients, stroke is the major cause of mortality and acquired disability in adults. 5 Stroke includes ischemic and hemorrhagic stroke, the former accounting for 80-87% of all stroke events.…”

Section: Introductionmentioning

confidence: 99%

Association between serum complement 1q and the associated factors of acute ischemic stroke in patients with type 2 diabetes

Fang

et al. 2023

Hum Exp Toxicol

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Objective The aim of this study was to examine the association between serum complement 1q (C1q) and the associated factors of acute ischemic stroke in patients with type 2 diabetes (T2DM). Methods The baseline clinical variables of the participants were collected, and the levels of blood lipids, blood sugar, inflammatory cytokines, and C1q in the three groups were then compared. The variables which affected the associated factors of acute ischemic stroke in T2DM cases were determined. Results The levels of C1q in the DAIS group were increased significantly compared with those in the T2DM group. Receiver operating characteristic curve analyses showed that the AUC for C1q and the combined diagnosis of acute ischemic stroke were 0.830 (95%CI 0.747–0.914), with a sensitivity of 0.854 and specificity of 0.780. The results of Pearson’s correlation analyses demonstrated that C1q was associated positively with low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (PBG), 2-h postprandial blood glucose (2h PG), and high-sensitive C reaction protein (hs-CRP) (all p < .05). Stratified analysis showed that there was a positive relationship between C1q and the associated factors of acute ischemic stroke for partial LDL-C, and hs-CRP strata. Logistic model analysis suggested that C1q was an independent risk factor for acute ischemic stroke in patients with T2DM. After adjusting for potential confounders, a one-standard deviation (SD) increase in C1q level was strongly related to an approximately 1.5-fold increased risk of acute ischemic stroke in cases with a hs-CRP ≥1.78 mg/L. Conclusion In DAIS patients, the levels of C1q were increased significantly and were an independent associated factor which affected the occurrence of acute ischemic stroke.

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Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke

Cited by 18 publications

References 77 publications

Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure

Association between serum complement 1q and the associated factors of acute ischemic stroke in patients with type 2 diabetes

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