Intestinal endometriosis without evident pelvic foci treated with gonadotropin-releasing hormone agonist

Bowel Endometriosis: Presentation, Diagnosis, and Treatment

“…Gonadotropin-releasing hormone agonist have been used with success in selected cases (37,38), but in general, bowel symptoms persist or recur when medical therapy is interrupted (24,39). It seems unlikely that patients with large bowel lesions may benefit from medical therapy because endometriosis is associated with fibrosis and sclerosis in the bowel wall, which are unresponsive to hormonal manipulation.…”

Intestinal endometriosis complicated by ileal perforation after initiation of gonadotropin-releasing hormone agonist therapy

“…One report found that 3 months of GnRH agonist therapy cleared the multilobulated polyp region of sigmoid endometriosis for at least 2 years (9). However, the flare-up induced by GnRH agonist can transiently exacerbate the disease, such as with the present case.…”

Bowel endometriosis: Recent insights and unsolved problems

“…However, most authors simply report the recurrence of pain symptoms when the therapy with GnRH-a was discontinued [36,37] . In one case report, the disappearance of an intestinal endometriotic polyp was reported after 3-mo treatment with GnRH-a [38] . More recently, a prospective study systematically investigated the effects of a 12-mo treatment with triptorelin and tibolone on pain and intestinal symptoms in 18 women with colorectal endometriotic nodules [39] .…”