Intestinal electrical stimulation improves delayed gastric emptying and vomiting induced by duodenal distension in dogs

Xu, Jiankun; Chen, J. D. Z.

doi:10.1111/j.1365-2982.2007.00995.x

Cited by 18 publications

(18 citation statements)

References 43 publications

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“…From among the already mentioned applications in regenerative medicine, the concept of a "wireless" stimulation mediated by piezoelectric materials could find several applications in life sciences wherever electrical stimulation is needed, e.g., deep brain stimulation [99], gastric stimulation for gastroparesis [100], cardiac pacing for various cardiac arythmias [101], skeletal muscle stimulation in various neuropathies [102], etc.…”

Section: Discussionmentioning

confidence: 99%

Applications of Piezoelectricity in Nanomedicine

Ciofani

Danti

Ricotti

et al. 2012

Nanomedicine and Nanotoxicology

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Abstract. In this Chapter, recent results about studies of interactions between piezoelectric nanoparticles and living systems will be discussed. As extremely innovative materials, great importance is devoted to the investigations of their stabilisation in physiological environments and to their biocompatibility. Applications as drug carriers and nanovectors will be thereafter described, and special attention will be dedicated to tissue engineering applications. Finally, preliminary results achieved by our group on "wireless" cell stimulation will be approached. IntroductionNanotechnology refers to the research and technology development at atomic, molecular and macromolecular scales, which leads to the controlled manipulation and study of structures and devices with length scales in the range of 1-100 nm [1].In the latest two decades, the research on nanotechnology has grown explosively with over 300,000 publications in the field of nanosciences according to ISI Web of Science. Among these spectacular developments, a new emerging field that combines nanotechnology and biotechnology -nanobiotechnology -is receiving a growing attention [2]. Nanostructured materials own unique properties which are of great interest for their potential applications as biomaterials, such as the large "surface-area to volume" ratio. Since life itself, fundamentally, is a collection of nanoscale processes occurring within cells [3], it is unavoidable and necessary to understand the impacts of the presence of nanomaterials inside the cells when one explores advantages and promises of nanomaterials for biomedical applications.In fact, it has been demonstrated that nanomaterials can interact both positively and negatively with different biological systems. Carbon nanotubes (CNTs), for

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Section: Discussionmentioning

confidence: 99%

Applications of Piezoelectricity in Nanomedicine

Ciofani

Danti

Ricotti

et al. 2012

Nanomedicine and Nanotoxicology

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“…A number of previous studies reported that duodenal nutrients or distension reduced proximal gastric tone, delayed gastric emptying, and increased pyloric contractions (17,32). Colon-rectal distension has been reported to induce delayed gastric emptying (20,31), abnormalities of gastric slow waves (1,21), and inhibition of proximal gastric tone (12).…”

Section: Effects Of Electrical Stimulation On Slow Waves and Optimal mentioning

confidence: 99%

Effects and mechanisms of gastrointestinal electrical stimulation on slow waves: a systematic canine study

Sun¹,

Guan²,

Yin

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Sun Y, Song GQ, Yin J, Lei Y, Chen JDZ. Effects and mechanisms of gastrointestinal electrical stimulation on slow waves: a systematic canine study. Am J Physiol Regul Integr Comp Physiol 297: R1392-R1399, 2009. First published August 26, 2009 doi:10.1152/ajpregu.00006.2009.-The aims of this study were to determine optimal pacing parameters of electrical stimulation on different gut segments and to investigate effects and possible mechanisms of gastrointestinal electrical stimulation on gut slow waves. Twelve female hound-mix dogs were used in this study. A total of six pairs of electrodes were implanted on the stomach, duodenum, and ascending colon. Bilateral truncal vagotomy was performed in six of the dogs. One experiment was designed to study the effects of the pacing frequency on the entrainment of gut slow waves. Another experiment was designed to study the modulatory effects of the vagal and sympathetic pathways on gastrointestinal pacing. The frequency of slow waves was 4.88 Ϯ 0.23 cpm (range, 4 -6 cpm) in the stomach and 19.68 Ϯ 0.31 cpm (range, 18 -22 cpm) in the duodenum. There were no consistent or dominant frequencies of the slow waves in the colon. The optimal parameters to entrain slow waves were: frequency of 1.1 intrinsic frequency (IF; 10% higher than IF) and pulse width of 150 -450 ms (mean, 320.0 Ϯ 85.4 ms) for the stomach, and 1.1 IF and 10 -20 ms for the small intestine. Electrical stimulation was not able to alter colon slow waves. The maximum entrainable frequency was 1.27 IF in the stomach and 1.21 IF in the duodenum. Gastrointestinal pacing was not blocked by vagotomy nor the application of an ␣-or ␤-adrenergic receptor antagonist; whereas the induction of gastric dysrhythmia with electrical stimulation was completely blocked by the application of the ␣-or ␤-adrenergic receptor antagonist. Gastrointestinal pacing is achievable in the stomach and small intestine but not the colon, and the maximal entrainable frequency of the gastric and small intestinal slow waves is about 20% higher than the IF. The entrainment of slow waves with gastrointestinal pacing is not modulated by the vagal or sympathetic pathways, suggesting a purely peripheral or muscle effect.

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“…Based on our knowledge, only dogs were used in prior GES studies and these investigations have two problems that limit interpretation. Firstly, they used non‐standard measures of emesis, often reporting a total ‘symptom score’ and not absolute, objectively quantifiable numbers of retches or vomits . The exception is one paper listing total emetic episodes; however, this report also has a potential confound by using repeated cisplatin chemotherapy injections in the same animals, with only the first test session as the control condition .…”

Section: Discussionmentioning

confidence: 99%

“…Although not specifically established for the vagus, it is known that cisplatin can produce peripheral neuropathy . The reported symptom scores were often combined with other measures, sometimes including licking tongue, closing eyes, yawning, belching, murmuring, rapid breathing, and defecating, and in other reports vomiting was scored 3 #bib4, or 5 if the symptoms occurred 1, 2, or 3 times and scored as ‘0’ if not present . We believe that these reports are largely not interpretable and difficult (if not impossible) to fit into the larger literature on emesis and evaluation of antiemetic therapies.…”

Section: Discussionmentioning

confidence: 99%

Impact of electrical stimulation of the stomach on gastric distension‐induced emesis in the musk shrew

Horn

Zirpel

Sciullo

et al. 2016

Neurogastroenterology Motil

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Background Gastric electrical stimulation (GES) is implicated as a potential therapy for difficult-to-treat nausea and vomiting; however, there is a lack of insight into the mechanisms responsible for these effects. The current study tested the relationship between acute GES and emesis in musk shrews, an established emetic model system. Methods Urethane-anesthetized shrews were used to record emetic responses (monitoring intra-tracheal pressure and esophageal contractions), respiration rate, heart rate variability, blood pressure, and gastrointestinal electromyograms. We investigated the effects of acute GES pulse duration (0.3, 1, 5, and 10 ms), current amplitude (0.5, 1, and 2 mA), pulse frequency (8, 15, 30, and 60 Hz), and electrode placement (antrum, body, and fundus) on emesis induced by gastric stretch, using a balloon. Key results There were four outcomes: (1) GES did not modify the effects of gastric stretch-induced emesis; (2) GES produced emesis, depending on the stimulation parameters, but was less effective than gastric stretch; (3) other physiological changes were closely associated with emesis and could be related to a sub-threshold activation of the emetic system, including suppression of breathing and rise in blood pressure; and (4) a control experiment showed that 8-OH-DPAT, a reported 5-HT1A receptor agonist that acts centrally as an antiemetic, blocked gastric stretch-induced emesis. Conclusions & Inferences These results do not support an antiemetic effect of acute GES on gastric distension-induced emesis within the range of conditions tested, but further evaluation should focus on a broader range of emetic stimuli and GES stimulation parameters.

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Intestinal electrical stimulation improves delayed gastric emptying and vomiting induced by duodenal distension in dogs

Cited by 18 publications

References 43 publications

Applications of Piezoelectricity in Nanomedicine

Applications of Piezoelectricity in Nanomedicine

Effects and mechanisms of gastrointestinal electrical stimulation on slow waves: a systematic canine study

Impact of electrical stimulation of the stomach on gastric distension‐induced emesis in the musk shrew

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