Intestinal electrical stimulation decreases postprandial blood glucose levels in rats

Khawaled, Radwan; Blumen, Gil; Fabricant, Gary; Ben-Arie, Jacob; Shikora, Scott A.

doi:10.1016/j.soard.2009.05.013

Cited by 17 publications

(11 citation statements)

References 27 publications

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“…Such reports have been made for the Entro-Medics VBLOC device (75). In addition, Khawaled et al (76) have shown, albeit in rats, that duodenal electrode stimulation will normalize diabetic blood glucose levels.…”

Section: Nonbariatric Metabolic Surgery For Diabetesmentioning

confidence: 99%

Metabolic (Bariatric and Nonbariatric) Surgery for Type 2 Diabetes: A Personal Perspective Review

Buchwald

Buchwald²

2019

Diabetes Care

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Metabolic surgery can cause amelioration, resolution, and possible cure of type 2 diabetes. Bariatric surgery is metabolic surgery. In the future, there will be metabolic surgery operations to treat type 2 diabetes that are not focused on weight loss. These procedures will rely on neurohormonal modulation related to the gut as well as outside the peritoneal cavity. Metabolic procedures are and will always be in flux as surgeons seek the safest and most effective operative modality; there is no enduring gold standard operation. Metabolic bariatric surgery for type 2 diabetes is more than part of the clinical armamentarium, it is an invitation to perform basic research and to achieve fundamental scientific knowledge. And the Lord God caused a deep sleep to fall upon Adam, and he slept; and he took one of his ribs, and closed up the flesh instead thereof, and the rib which the Lord had taken from man, made he a woman.. .. dGenesis 2:21-22 METABOLIC SURGERY In 1978, in the foreword to the book Metabolic Surgery (1), by author H.B. and Richard L. Varco, we defined the discipline of metabolic surgery "as the operative manipulation of a normal organ or organ system to achieve a biological result for a potential health gain." The procedure described in Genesis was an "operative manipulation" under general anesthesia on a "normal organ" to achieve a "biological result"; it was metabolic surgery. As early as 1896, bilateral oophorectomy was used to cause temporary regression of breast cancer metastases (2). The 100-year heyday of peptic, primarily duodenal, ulcer surgery, from the late 19th century to the discovery of Helicobacter pylori, involved operating on normal stomachs and vagus nerves to cure the pathologic lesion, a distal ulcer left untouched by the surgeon. This was metabolic surgery, as was the partial ileal bypass (Fig. 1) for the treatment of hypercholesterolemia, introduced in 1962 and 1963 (3,4). The partial ileal bypass was used as the intervention modality in the Program on the Surgical Control of the Hyperlipidemias (POSCH) (5-8), the first randomized controlled trial to use metabolic surgery. POSCH was the first study definitively to demonstrate the benefits of marked cholesterol lowering in preventing myocardial infarctions, peripheral vascular disease, and the need for coronary artery

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Section: Nonbariatric Metabolic Surgery For Diabetesmentioning

confidence: 99%

Metabolic (Bariatric and Nonbariatric) Surgery for Type 2 Diabetes: A Personal Perspective Review

Buchwald

Buchwald²

2019

Diabetes Care

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“…Reduced meal sizes occurring with the BALANCE system could be the result of a decreased gastric emptying as shown in the preclinical rat model [9]. Also, Liu et al demonstrated delayed gastric emptying and decreased water intake through an endoscopically placed feeding tube in healthy volunteers under IES conditions [10].…”

Section: Discussionmentioning

confidence: 99%

“…Electric stimulation has also been shown to reduce food intake, decrease blood glucose levels, and induce weight loss in animals [7,8]. Moreover, Khawaled et al demonstrated a decrease of gastric emptying and an increase of intestinal flow in rats treated with duodenal electrical stimulation [9].…”

Section: Introductionmentioning

confidence: 99%

“…The hypothesis underlying our study was that an implanted electric duodenal stimulation system (EDS, BALANCE system) is able to mimic the effects of a gastric bypass through electrical stimulation of the duodenal wall and lead to similar effects in humans as seen in rats [9]. It was our aim to investigate the feasibility and safety of the EDS implanted in humans.…”

Section: Introductionmentioning

confidence: 99%

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Duodenal Electric Stimulation

Aberle

Busch²,

Veigel

et al. 2015

OBES SURG

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“…IES applied to the duodenum was shown to decrease postprandial blood glucose level with a concurrent decrease in insulin secretion in anesthetized rats. The authors believed it was possibly because of delayed gastric emptying and increased intestinal flow rate of nutrients (67). A later study by Sandoval et al (68) indicated IES in combination with nutrient infusion significantly increased plasma GLP-1, which is known to have a hypoglycemic effect.…”

Section: Potentials Of Ies For Obesity and Diabetesmentioning

confidence: 99%

Gastrointestinal Electrical Neuromodulation for Functional Gastrointestinal Diseases, Obesity and Diabetes

Yin

Chen

2015

Bioelectron Med

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Intestinal electrical stimulation decreases postprandial blood glucose levels in rats

Cited by 17 publications

References 27 publications

Metabolic (Bariatric and Nonbariatric) Surgery for Type 2 Diabetes: A Personal Perspective Review

Metabolic (Bariatric and Nonbariatric) Surgery for Type 2 Diabetes: A Personal Perspective Review

Duodenal Electric Stimulation

Gastrointestinal Electrical Neuromodulation for Functional Gastrointestinal Diseases, Obesity and Diabetes

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