Bacterial infections are common complications in patients with cirrhosis, with up to 47% of hospitalised cirrhotics having infection [1]. Nevertheless, bacteremic episodes caused by anaerobes are unusual and the clinical importance of Clostridium bacteremia remains unclear. We report a case of bacteremia caused by Clostridium in a patient with a nonresecable hepatocellular carcinoma and hepatitis C virus-related cirrhosis.A 69-year-old man with a history of hepatitis C virusrelated cirrhosis, Child-Pugh A, with a nonresectable hepatocellular carcinoma, diagnosed 4 months previously, and without previous decompensations was admitted for upperright abdominal pain and fever of 72-hr duration. At admission, the patient did not have ascites or hepatic encephalopathy; arterial pressure was 128/68 mm Hg. Urinalysis and chest x-ray did not show any sign of infection. Because of the presence of leukocytosis in the peripheral blood count (white blood cells, 22,200 × 10 9 /L; 84N% neutrophils, 7% band cells) and right colonic wall thickening with pneumatosis in the abdominal ultrasound and CT, empirical antibiotic therapy with imipenem was started. Blood culture evidenced a Clostridium sp. infection susceptible to imipenem. Clostridium sepsis was diagnosed and the patient was discharged after 15 days of antibiotic treatment.The portal of entry of Clostridium sp. in cirrhotic patients is usually obscure and the gastrointestinal tract is the most likely source. Colonic mucosal changes commonly occur in patients with liver cirrhosis [2], and vasculopathy of colonic mucosa may result from changes in the intestinal microcirculation, which are probably secondary to portal hypertension [3]. The high concentration of clostridial organisms in the gastrointestinal tract, coupled with systemic illness, might allow transmucosal migration of these organisms, resulting in systemic bacteremia. Nevertheless, primary Clostridium bacteremia in cirrhotic patients is very uncommon and has not yet been reported at our hospital despite a review of all episodes of anaerobic bacteremia. The association between intestinal wall edema and cirrhosis is well recognized [4], and hypoproteinemia has been postulated as the primary cause [5]. Patients with severe cirrhosis who undergo CT can show assymptomatic colonic wall thickening limited predominantly to the right colon and related to changes in blood flow and hydrostatic pressures caused by portal hypertension [6]; but as in our case, colonic pneumatosis may indicate a more serious problem such as ischemia or infection. Previous studies have demonstrated that septic shock at initial presentation was linked to a fatal outcome, and underlying liver cirrhosis was also associated with a poor prognosis [7]. Clostridium sp. in the bloodstream could be merely a contaminant or transient bacteremia; therefore, the clinical importance of Clostridium bacteremia should be interpreted with caution because of its high risk of mortality in susceptible hosts, particularly cirrhotic patients, who do not receive approp...