Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis

Han, Hui; Jiang, Yi; Wang, Mengyu; Melaku, Mebratu; Liu, Lei; Zhao, Yong; Everaert, Nadia; Yi, Bao; Zhang, Hongfu

doi:10.1080/10408398.2021.1966738

Cited by 72 publications

(67 citation statements)

References 179 publications

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“…Accumulating evidence suggests that gut microbiota involves in various perspectives of host health ( 20 , 21 ). Moreover, previous studies have well-established the causal relationship between the gut microbiota and sperm quality in both animal models and humans ( 1 , 12 , 13 , 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol Benefits Boar Semen Quality via Improving Gut Microbiota and Blood Metabolome

et al. 2022

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Semen quality is one of the most important factors for the success of artificial insemination which has been widely applied in swine industry to take the advantages of the superior genetic background and higher fertility capability of boars. Hydroxytyrosol (HT), a polyphenol, has attracted broad interest due to its strong antioxidant, anti-inflammatory, and antibacterial activities. Sperm plasma membrane contains a large proportion of polyunsaturated fatty acids which is easily impaired by oxidative stress and thus to diminish semen quality. In current investigation, we aimed to explore the effects of dietary supplementation of HT on boar semen quality and the underlying mechanisms. Dietary supplementation of HT tended to increase sperm motility and semen volume/ejaculation. And the follow-up 2 months (without HT, just basal diet), the semen volume was significantly more while the abnormal sperm was less in HT group than that in control group. HT increased the “beneficial microbes” Bifidobacterium, Lactobacillus, Eubacterium, Intestinimonas, Coprococcus, and Butyricicoccus, however, decreased the relative abundance of “harmful microbes” Streptococcus, Oscillibacter, Clostridium_sensu_stricto, Escherichia, Phascolarctobacterium, and Barnesiella. Furthermore, HT increased plamsa steroid hormones such as testosterone and its derivatives, and antioxidant molecules while decreased bile acids and the derivatives. All the data suggest that HT improves gut microbiota to benefit plasma metabolites then to enhance spermatogenesis and semen quality. HT may be used as dietary additive to enhance boar semen quality in swine industry.

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Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol Benefits Boar Semen Quality via Improving Gut Microbiota and Blood Metabolome

et al. 2022

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“…Hou et al showed that the gut-liver FXR-FGF19 axis is involved in Lactobacillus delbrueckii-promoted ileal bile acid deconjugation. In our previous studies, we found that gut microbiota-derived metabolites are highly associated with host metabolic reprograming (9)(10)(11)(12). Furthermore, bacterial microRNA, bacteriocin, and microbiota sensing pathways have also been identified to be involved in the relationship between gut microbiota and host metabolism (13,14).…”

Section: Gut Microbial Response To Host Metabolic Phenotypesmentioning

confidence: 97%

Editorial: Gut Microbial Response to Host Metabolic Phenotypes

Yin

Han

2022

Front. Nutr.

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“…The gut-liver axis is the mutual communication between the intestine and the liver (Figure 1). This axis is connected by portal circulation, the bile tract, as well as systematic circulation [13]. The liver obtains more than two-thirds of its blood from the gastrointestinal tract by the portal system.…”

Section: Introductionmentioning

confidence: 99%

The Role of Gut–Liver Axis in Gut Microbiome Dysbiosis Associated NAFLD and NAFLD-HCC

Song

Zhang

2022

Biomedicines

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Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most prevalent chronic liver diseases worldwide due to the rapidly rising prevalence of obesity and metabolic syndrome. As a hepatic manifestation of metabolic disease, NAFLD begins with hepatic fat accumulation and progresses to hepatic inflammation, termed as non-alcoholic steatohepatitis (NASH), hepatic fibrosis/cirrhosis, and finally leading to NAFLD-related hepatocellular carcinoma (NAFLD-HCC). Accumulating evidence showed that the gut microbiome plays a vital role in the initiation and progression of NAFLD through the gut–liver axis. The gut–liver axis is the mutual communication between gut and liver comprising the portal circulation, bile duct, and systematic circulation. The gut microbiome dysbiosis contributes to NAFLD development by dysregulating the gut–liver axis, leading to increased intestinal permeability and unrestrained transfer of microbial metabolites into the liver. In this review, we systematically summarized the up-to-date information of gut microbiome dysbiosis and metabolomic changes along the stages of steatosis, NASH, fibrosis, and NAFLD-HCC. The components and functions of the gut–liver axis and its association with NAFLD were then discussed. In addition, we highlighted current knowledge of gut microbiome-based treatment strategies targeting the gut–liver axis for preventing NAFLD and its associated HCC.

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Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis

Cited by 72 publications

References 179 publications

Hydroxytyrosol Benefits Boar Semen Quality via Improving Gut Microbiota and Blood Metabolome

Hydroxytyrosol Benefits Boar Semen Quality via Improving Gut Microbiota and Blood Metabolome

Editorial: Gut Microbial Response to Host Metabolic Phenotypes

The Role of Gut–Liver Axis in Gut Microbiome Dysbiosis Associated NAFLD and NAFLD-HCC

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