Intestinal disaccharidase activities in relation to age, race, and mucosal damage

A genetic test which can be used to diagnose adult-type hypolactasia in children

“…[27][28][29][30][31] In black populations adulttype hypolactasia has been shown to manifest between 1-8 years of age, whereas in White populations low lactase levels are rarely seen in children under 5 years of age. [27][28][29][30][31] Previous studies of the Finnish population, based on the lactose tolerance test, have shown adult-type hypolactasia to manifest up to 20 years of age. 27 In most children with the C/C -13910 genotype tested at 8 years of age and in all children tested at 12 years of age lactase activity had declined to ,10 U/g protein in this study.…”

Clinical Aspects and Treatment of Congenital Sucrase‐Isomaltase Deficiency

“…These studies evolved from older studies of intestinal disaccharidase levels in adult patients undergoing endoscopy for gastrointestinal symptoms (15,16). The estimates have shown low levels of sucrase activity >1 standard deviation (SD) below the mean in mucosal biopsy specimens from 2% to 9% of patients, even in the absence of overt mucosal injury.…”

Trehalose: Current Use and Future Applications

“…Upon ingestion, trehalose is enzymatically hydrolyzed in the small intestine by a trehalosespecific disaccharidase (trehalase) into two D-glucose molecules, which are subsequently absorbed and metabolized. 290 Although there are no gender-or ageassociated differences in trehalase activity, 291 there are reports of ethnic differences in the ability to ingest trehalose; slightly lower capacity to tolerate trehalose was noted in Asian populations. [292][293][294][295] Despite these differences, safe human consumption of trehalose in doses up to 50 g has been demonstrated; 292 thus, there appears to be no barrier for the inclusion of trehalose in future food products.…”