Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men

Mann, Elizabeth R.; Landy, Jonathan; Bernardo, David; Peake, S.; Hart, Ailsa; Al-Hassi, Hafid O.; Knight, Stella C.

doi:10.1016/j.imlet.2013.01.007

Cited by 88 publications

(93 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…85,107,118,[202][203][204][205] However many phenotypic markers of the myeloid lineage including CD11b, F4/80 and CD11c…”

Section: Human Intestinal Macrophagesmentioning

confidence: 99%

“…5 CD163 or CD206 are also expressed by most mature m in humans, but they express low amounts of CD14, which is found at high levels on classical monocytes and immature m . 85,107,118,[202][203][204][205] Using markers of this kind, it can be shown that a monocyte-m "waterfall" 142 Indeed, there appear to be several differences in how responsiveness to pattern recognition receptors is regulated in human and murine m in general. 206 As in mice however, IL-10 plays an essential role in controlling the pro-inflammatory potential of human intestinal m and non-functional mutations in the IL-10R lead to severe, early onset IBD.…”

Section: Human Intestinal Macrophagesmentioning

confidence: 99%

See 1 more Smart Citation

Diversity and functions of intestinal mononuclear phagocytes

et al. 2017

View full text Add to dashboard Cite

“…85,107,118,[202][203][204][205] However many phenotypic markers of the myeloid lineage including CD11b, F4/80 and CD11c…”

Section: Human Intestinal Macrophagesmentioning

confidence: 99%

Section: Human Intestinal Macrophagesmentioning

confidence: 99%

Diversity and functions of intestinal mononuclear phagocytes

et al. 2017

View full text Add to dashboard Cite

“…In the proximal gut segments, even under homeostasis, where the microbiota is rare, some commensal bacteria can be in close contact with the epithelial cells. The IS scavenges these bacteria and generates primary T-cell responses, either immunogenic or tolerogenic (24). However, this concept, validated in healthy subjects and in patients with inflammatory bowel disease, has to be reconsidered in metabolic diseases, because gut dysbiosis can be induced within a few days or weeks by a diet change (25), allowing pathogens to penetrate the body without being destroyed by the innate and specific adaptive ISs, through a nucleotide-binding oligomerization domain 1-and LPS-cluster of differentiation 14-dependent translocation mechanism, which, when hampered, improves insulin sensitivity (26).…”

mentioning

confidence: 99%

The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood

et al. 2014

View full text Add to dashboard Cite

“…Interestingly, however, the expression of CX3CR1 + in macrophages that were isolated from colon differs considerably from those isolated from the duodenum, jejunum and ileum, suggesting that the instructions that macrophages receive from these regions are variable. This makes it clear that distinct commensal populations in different regions of the intestine give signals to these cells, influencing their profiles [86] . The role of gut microbiota in macrophage and DC development is not clear.…”

Section: Cx3cr1mentioning

confidence: 99%

Intestinal barrier: A gentlemen’s agreement between microbiota and immunity

Caricilli

Castoldi

Câmara

2014

WJGP

109

View full text Add to dashboard Cite

Our body is colonized by more than a hundred trillion commensals, represented by viruses, bacteria and fungi. This complex interaction has shown that the microbiome system contributes to the host's adaptation to its environment, providing genes and functionality that give flexibility of diet and modulate the immune system in order not to reject these symbionts. In the intestine, specifically, the microbiota helps developing organ structures, participates of the metabolism of nutrients and induces immunity. Certain components of the microbiota have been shown to trigger inflammatory responses, whereas others, anti-inflammatory responses. The diversity and the composition of the microbiota, thus, play a key role in the maintenance of intestinal homeostasis and explain partially the link between intestinal microbiota changes and gut-related disorders in humans. Tight junction proteins are key molecules for determination of the paracellular permeability. In the context of intestinal inflammatory diseases, the intestinal barrier is compromised, and decreased expression and differential distribution of tight junction proteins is observed. It is still unclear what is the nature of the luminal or mucosal factors that affect the tight junction proteins function, but the modulation of the immune cells found in the intestinal lamina propria is hypothesized as having a role in this modulation. In this review, we provide an overview of the current understanding of the interaction of the gut microbiota with the immune system in the development and maintenance of the intestinal barrier.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Microbiota; Immune system; Lamina propria; Intestinal barrier Core tip: Each of our bodies is colonized by more than a hundred trillion commensals, which include viruses, bacteria and fungi. The association between microbiota and their hosts is complex and has important repercussions for both. The diversity and the composition of the microbiota thus play a key role in the maintenance of intestinal homeostasis and the induction of immunity. These features partially explain the link between alterations in intestinal microbiota and gut-related disorders in humans. In this review, we provide an overview of the current understanding of the interaction between gut microbiota and the immune system in the development and maintenance of the intestinal barrier.Caricilli AM, Castoldi A, Câmara NOS. Intestinal barrier: A gentlemen's agreement between microbiota and immunity.

show abstract

Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men

Cited by 88 publications

References 163 publications

Diversity and functions of intestinal mononuclear phagocytes

Diversity and functions of intestinal mononuclear phagocytes

The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood

Intestinal barrier: A gentlemen’s agreement between microbiota and immunity

Contact Info

Product

Resources

About