Intestinal delivery of ROS-scavenging carbonized polymer dots for full-course treatment of acute and chronic radiation enteritis

Zhang, Jiaxin; Yang, Mingxi; Tang, Xiaoduo; Li, Shuang; Zhang, Junhu; Lu, Laijin; Wang, Quan; Yang, Bai

doi:10.1016/j.apmt.2022.101544

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…1f ), which was beneficial for deep tissue imaging to track drugs. 28 In the UV-Vis spectrum of GB-CPDs (Fig. 1g), increased B-band absorption could be clearly observed at around 230 nm, according to the benzene ring of GB, which further confirmed that the surface of CPDs was successfully modified by GB.…”

Section: Papersupporting

confidence: 55%

Brain-targeted ginkgolide B-modified carbonized polymer dots for alleviating cerebral ischemia reperfusion injury

et al. 2023

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Section: Papersupporting

confidence: 55%

Brain-targeted ginkgolide B-modified carbonized polymer dots for alleviating cerebral ischemia reperfusion injury

et al. 2023

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“…Excessive ROS might damage DNA, proteins, lipids, etc., leading to various diseases, and it has been shown that certain diseases such as aging, inflammation, and myocardial infarction are intimately related to ROS. − CS molecular chains have a multitude of amino and hydroxyl groups with active hydrogen, and in recent years, researchers have found that CS has excellent ROS scavenging ability. ,, Therefore, the scavenging effect of TPP copoly -CDs on three typical ROS (·OH, DPPH·, and ·O 2 – ) was assessed in vitro. Measurements and calculations were performed according to the method in Section 2.3 of the Supporting Information, and the results obtained are shown in Figures and S8.…”

Section: Resultsmentioning

confidence: 99%

Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

Li,

et al. 2024

ACS Appl. Mater. Interfaces

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Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented synthesis of TPP-CDs and the regulation of TPP linkage modes remain challenges. Herein, we propose a free-radical-initiated random copolymerization in combination with hydrothermal carbonation to regulate the TPP backbone linkage for target-oriented synthesis of triphenylphosphine copolymerization carbon dots (TPPcopoly-CDs). The linkage mechanism of random copolymerization reactions is directional, straightforward, and controllable. The TPP content and IC50 of hydroxyl radicals scavenging ability of TPPcopoly-CDs are 53 wt % and 0.52 mg/mL, respectively. TPP serves as a charge control agent to elevate the negatively charged CDs by 20 mV. TPPcopoly-CDs with negative charge can target mitochondria, and in the corresponding mechanism the TPP moiety plays a crucial role in targeting mitochondria. This discovery provides a new perspective on the controlled synthesis, TPP linkage modes, and mitochondrial targeting design of TPP-CDs.

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“…Despite advancements in three-dimensional conformal and intensity-modulated radiotherapy, inadvertent exposure of nearby healthy organs to radiation can lead to radiation-induced diseases [2]. The intestine, the second most radiation-sensitive organ in the body, is particularly susceptible to damage during pelvic radiation due to its location within the abdominal cavity [3]. Notably, over 75% of patients undergoing pelvic radiotherapy develop radiation enteritis, which significantly impairs their quality of life and may pose life-threatening risks [4].…”

Section: Introductionmentioning

confidence: 99%

Oral Curcumin–Thioketal–Inulin Conjugate Micelles against Radiation–Induced Enteritis

Shen,

Jiao,

Yuan

et al. 2024

Antioxidants

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Radiation–induced enteritis is an unavoidable complication associated with pelvic tumor radiotherapy, significantly influencing the prognosis of cancer patients. The limited availability of commercial gastrointestinal radioprotectors in clinical settings poses a substantial challenge in preventing radiation enteritis. Despite the inherent radioprotective characteristics of Cur in vitro, its poor solubility in water, instability, and low bioavailability lead to inferior therapeutic effects in vivo. Herein, we developed novel ROS-responsive micelles (CTI) from inulin and curcumin, aimed at mitigating radiation enteritis. CTI micelles had excellent solubility and stability. Importantly, CTI improved the cytotoxicity and bioavailability of curcumin, thereby showing enhanced effectiveness in neutralizing ROS induced by radiation, safeguarding against DNA damage, and reducing radiation-induced cellular mortality. Moreover, in a radiation enteritis mice model, CTI not only alleviated severe radiation-induced intestinal injury but also improved redox-related indicators and reduced inflammatory cytokine expression. Furthermore, CTI effectively increased gut microbiota abundance and maintained gut homeostasis. In conclusion, CTI could be a promising candidate for the clinical management of radiation enteritis. Our study provides a new perspective for radioprotection using natural antioxidants.

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Intestinal delivery of ROS-scavenging carbonized polymer dots for full-course treatment of acute and chronic radiation enteritis

Cited by 6 publications

References 48 publications

Brain-targeted ginkgolide B-modified carbonized polymer dots for alleviating cerebral ischemia reperfusion injury

Brain-targeted ginkgolide B-modified carbonized polymer dots for alleviating cerebral ischemia reperfusion injury

Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

Oral Curcumin–Thioketal–Inulin Conjugate Micelles against Radiation–Induced Enteritis

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