Intestinal Damage and Malabsorption after Treatment for Cervical Carcinoma

Lantz, Bo M.T.; Einhorn, Nina

doi:10.3109/02841868409135982

Cited by 16 publications

(4 citation statements)

References 7 publications

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“…29,270 Pelvic and abdominal radiotherapy often result in gastrointestinal dysfunction with chronic diarrhea, increased stool frequency, and faster small bowel and whole gut transit. This may result in a malabsorption of bile acids and vitamin B 12 [271][272][273][274][275][276][277][278] and even folate. 273 In some cases antibiotic treatment in addition to vitamin supplementation may be warranted if intestinal bypass surgery is combined with radiotherapy.…”

Section: Intestinal Diseasesmentioning

confidence: 99%

“…This may result in a malabsorption of bile acids and vitamin B 12 [271][272][273][274][275][276][277][278] and even folate. 273 In some cases antibiotic treatment in addition to vitamin supplementation may be warranted if intestinal bypass surgery is combined with radiotherapy. 271 The importance of adequate folate status in chronic inflammatory bowel disease is underlined by recent investigations demonstrating an increased risk of colon cancer.…”

Section: Intestinal Diseasesmentioning

confidence: 99%

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Biological and Environmental Determinants of Plasma Homocysteine

Schneede¹,

Refsum²,

Ueland³

2000

Semin Thromb Hemost

117

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This article gives an overview over common physiological, lifestyle, and pathological conditions that may modulate the homocysteine status. The interplay of several environmental factors, including age, gender, nutrition, smoking, and coffee consumption and physical activity with commonly used drugs and prevalent diseases are described. In most cases, an abnormal homocysteine status is not caused by a single factor alone but often is the result of combined effects. We address these frequently found "clusters" of homocysteine-modulating factors. Finally, we give an overview of likely causes of hyperhomocysteinemia found in an authentic material. This material is based on 2462 routine measurements of plasma total homocysteine carried out at the Haukeland University Hospital. The data represent the total number of combined homocysteine and methylmalonic acid determinations, requested by general practitioners in Norway during February 1998.

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Section: Intestinal Diseasesmentioning

confidence: 99%

Section: Intestinal Diseasesmentioning

confidence: 99%

Biological and Environmental Determinants of Plasma Homocysteine

Schneede¹,

Refsum²,

Ueland³

2000

Semin Thromb Hemost

117

View full text Add to dashboard Cite

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“…The most critical factor contributing to intestinal dysfunction is that RT to pelvic cavity can easily cause telangiectasis of the rectum and damages to the blood vessels of rectal tissues, causing mucous membrane to be pale and fragile, and finally necrotic 21 . It is also reported that RT to pelvic cavity could result in other parameters associated with intestinal dysfunction, such as an imbalance of intestinal bacteria, bile salt and lactose dysabsorption, and altered intestinal peristalsis [22][23][24][25] . Additionally, higher morbidity of severe lower extremities edema, even in grade 4 toxicity, was found in the RT group.…”

Section: Discussionmentioning

confidence: 99%

The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China

Yang

Yuan

Zeng

et al. 2020

Sci Rep

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Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage of the histological types. the presence of aggressive pathologic risk factors following patients' primary surgery may warrant the use of adjuvant radiotherapy. it is important to weigh up the risks and benefits of using adjuvant radiotherapy for each young patient so as to maximize their prognosis while minimizing the treatment-related morbidity. Methods: A retrospective study was performed. It consisted of 97 patients under 35 years old who were diagnosed with cervical squamous cell carcinoma and underwent treatment at West china Second University Hospital between December 2009 and January 2014. Five-year follow-up, prognostic risks, long-term radiation toxicity, female sexual function, and quality of life were investigated. Results: Adjuvant radiotherapy did improve the prognosis of young patients with lymph node metastases. However, there were few significant differences in progress-free survival and overall survival for the young patients without lymph node metastases following adjuvant radiotherapy. Besides, young patients who took radiotherapy exhibited greater intestinal dysfunction, more severe lower extremities edema, greater sexual dysfunction, and worse long-term quality of life. conclusion: Young patients with early-stage cervical squamous cell carcinoma without lymph node metastases who have undergone the primary surgery should be counseled in detail before the decision to use adjuvant radiotherapy can be made. the counseling should emphasize not only the benefit that local recurrence rates can be reduced, but also the risks that treatment-related side effects could increase and lower QoL could occur. Thanks to widespread screening and advanced medical treatment, the incidence and the mortality of cervical cancer have been reduced in developed countries 1. However, in the rural developing regions of China, the morbidity of cervical cancer is still high due to the suboptimal medical conditions, making the cervical cancer a major health problem for women 2,3. Recent studies showed that the incidence of cervical cancer in young women is rising and squamous cell carcinoma (SCC) still makes up a great percentage of the histological types 4,5. To our best knowledge, the persistent infection of high-risk human papillomavirus (HPV) is identified as the most critical factor for the development of cervical cancer 6,7. For young women, the squamous-columnar junction of cervix is more vulnerable to HPV infection if she has an early age of active intercourse.

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“…Lantz & Einhorn followed 32 patients for 14 to 16 years after radiotherapy for cervical carcinoma, for whom 23 consented to have blood drawn for analysis. Folate levels were below normal in 13% and in the low to normal range in 22% (16). McBrien studied 14 patients who had undergone radiation for bladder cancer by conducting Schilling tests 24 months after completing radiation; the tests showed that 8 of 14 patients had abnormally low levels of B-12118}.…”

Section: Discussionmentioning

confidence: 99%

Parameters of small bowel dysfunction in cervical cancer patients undergoing radiotherapy

Patton¹,

Mitchell²,

Atkinson

et al. 1993

Int J Gynecol Cancer

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Small bowel dysfunction is an important problem in patients undergoing radiotherapy for cervical cancer and may take many forms. The spectrum of small bowel dysfunction includes subtle findings such as malabsorption and more obvious complications such as obstruction and fistula formation. Predicting who will experience small bowel dysfunction is important so that prospective studies of these compications can be planned. We undertook a controlled retrospective review of patients with stage IB cervical carcinoma looking for parameters of small bowel dysfunction and their predictors to help in the design of a prospective study. This analysis suggests that the interval to development is long. The best predictor of diarrhea requiring medication was the number of laparotomies. A large sample size of stage IB patients would be necessary to prospectively study small bowel dysfunction in this population.

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Intestinal Damage and Malabsorption after Treatment for Cervical Carcinoma

Cited by 16 publications

References 7 publications

Biological and Environmental Determinants of Plasma Homocysteine

Biological and Environmental Determinants of Plasma Homocysteine

The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China

Parameters of small bowel dysfunction in cervical cancer patients undergoing radiotherapy

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