Intestinal colonization resistance is associated with hyperoxaluria in the patients with recurrent pyelonephritis

Stepanova, N.; Stashevska, N.; Driianska, V.; Kolesnyk, М.

doi:10.1016/s1569-9056(17)30298-1

Cited by 2 publications

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“…Український журнал нефрології та діалізу Оригінальні наукові роботи формування бактеріальної резистентності обґрунтовують необхідність мінімізації застосування антибактеріальних лікарських засобів (АЛЗ) та удосконалення альтернативних підходів до лікування і профілактики рПН [9,15]. Профілактика рПН із застосування АЛЗ для з одного боку, запобігає рецидиву, але з іншого -порушує кількісний та якісний склад мікробіоти кишківника з наступним формуванням гіпероксалурії [1,4,[18][19][20].…”

Section: №4 (56) 2017unclassified

“…Результати наших попередніх досліджень визначили значну поширеність (> 80%) гіпероксалурії у жінок з рПН [1,4,19]. Порушення мікрофлори кішківника з подальшим розвитком дисбіозу з одного боку є основним джерелом інфікування сечової системи, з іншого -призводить до посиленого всмоктування оксалатів та набутої кишкової гіпероксалурії.…”

Section: №4 (56) 2017unclassified

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Effects of Lactic Acid Bacteria Probiotic on Urinare Oxalate Excretion and Prevention of Recurrent Pyelonephritis

Stepanova

Stashevska

Lebid

et al. 2017

Ukr. Journ. Nephrol. and Dial.

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The present study was performed to evaluate the ability of Lactobacillus probiotics to reduce the urinary oxalate excretion level and prevent recurrent pyelonephritis. Methods. The open, 6 months randomized controlled trial was followed up. 80 women with recurrent pyelonephritis, caused by E. coli or S. faecalis, were randomly allocated into 2 groups. The 1st Group (n = 40) took Symbiform® which contained acidophilic and plantar Lactobacilli, Lactococci (lactis and cremoris), Bifidobacteria (adolescentis and bifidum) and thermophilic non–pathogenic Streptococcus. The 2nd one (n = 40) received oxalate–soluble herbal remedy Uronefron® containing 188 mg of city extract from 9 plants. Probiotic was prescribed in a dose of 1 sachet 2 times a day during the first 5 days, followed by a dose reduction of 1 sachet per day for a month. Uronefron® was prescribed in a dose of 3 pills a day for a month. Results. 1 month after the end of the treatment, microbiological studies of the colon microflora demonstrated the increasing level of Lactobacillus spp. colonization more than 7 million CPU/1 g of faeces: 35/40 (87.5 %) in the patients of the 1st Group vs 6/40 (15 %) in the women of the comparison Group f/f = 41.5; p < 0.0001). The levels of daily urinary oxalate excretion were significantly decreased in both groups: the patients of Probiotic Group: 117.6 ± 11.7 vs 71.9 ± 10.07mg/d after the treatment (p < 0.0001) and 122.02 ± 17 vs 84.8 ± 9.8 mg/d (p < 0.0001) in the women of the 2nd Group, respectively. In the 6 months preceding randomization, at least 1 recurrence of pyelonephritis occurred in 2/40 (5 %) women of the Probiotic Group and 9/40 (22.5 %) in the patients of Group II (//= 5,1; p = 0,02). Conclusions. The use of lactobacillus probiotics in non–stone fanners women with recurrent pyelonephritis increases the quantitative content of Lactobacillus spp. in the gut, reduces daily urinary oxalate excretion and the number of pyelonephritis recurrences.

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Section: №4 (56) 2017unclassified

Effects of Lactic Acid Bacteria Probiotic on Urinare Oxalate Excretion and Prevention of Recurrent Pyelonephritis

Stepanova

Stashevska

Lebid

et al. 2017

Ukr. Journ. Nephrol. and Dial.

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“…and Bifidobacteria, and an increased number of conditionally pathogenic enterobacteria, E. coli , Clostridium , and Staphylococcus spp . in feces samples ( Stepanova et al, 2017 ; Stepanova et al, 2018b ). It should be noted, that all the examined patients had increased levels of sIg A and myeloperoxidase activity in coprofiltrates, which suggested enteric inflammation, while only 20% had clinical symptoms of gut dysbiosis.…”

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confidence: 99%

How Advanced Is Our Understanding of the Role of Intestinal Barrier Dysfunction in the Pathogenesis of Recurrent Urinary Tract Infections

Stepanova

2022

Front. Pharmacol.

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A comprehensive understanding of urinary tract infections (UTIs), one of the most common human infections, is required as they are complex and poorly understood diseases. Periurethral and vaginal colonization by rectal flora, with the constant presence of pathogens in the urethra, is the initial step of the recurrent UTIs pathway. Current scientific data describe the genetic, etiological, biological, and behavioral risk factors for recurring UTIs, but they do not include the effect of intestinal barrier function on the disease. Although gut microbiota has been proposed as the main source for UTIs, the cross-talk between intestinal barrier dysfunction and the recurrence of UTIs has not yet been supported by scientific data. In this opinion review, based on published data and the results of our clinical studies, I aimed to outline the possible contribution of intestinal barrier dysfunction to the pathogenesis of recurrent UTIs. I believe that the unanswered questions raised by this review can guide further experimental and controlled studies to clarify the mechanisms underlying the role of intestinal barrier dysfunction in the pathogenesis of recurrent UTIs.

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Intestinal colonization resistance is associated with hyperoxaluria in the patients with recurrent pyelonephritis

Abstract: 233Intestinal colonization resistance is associated with hyperoxaluria in the patients with recurrent pyelonephritis Eur Urol Suppl 2017; 16(3);e402Stepanova N.,

Cited by 2 publications

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Effects of Lactic Acid Bacteria Probiotic on Urinare Oxalate Excretion and Prevention of Recurrent Pyelonephritis

Effects of Lactic Acid Bacteria Probiotic on Urinare Oxalate Excretion and Prevention of Recurrent Pyelonephritis

How Advanced Is Our Understanding of the Role of Intestinal Barrier Dysfunction in the Pathogenesis of Recurrent Urinary Tract Infections

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