Intestinal changes associated with nitrite exposure in Bufo gargarizans larvae: Histological damage, immune response, and microbiota dysbiosis

Liu, Yutian; Wang, Hemei; Wu, Lifeng; Han, Jian; Sui, Baoying; Meng, Lingna; Xu, Yunxuan; Lu, Siwen; Wang, Hongyuan; Peng, Jufang

doi:10.1016/j.aquatox.2022.106228

Cited by 5 publications

(2 citation statements)

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“…Under pH and nitrite nitrogen stress, NO 2 − competes with Cl − and affects the exchange of HCO 3 − with Cl − , resulting in an imbalance of ionic balance in the spotted babylon organism [ 30 ]. The toxicity of nitrite nitrogen is also manifested in the form of HNO 2 , which can diffuse into cell membranes and, because of its strong oxidizing properties, can destroy the tissue structure and cellular components of spotted babylon, leading to metabolic disorders and a reduction in nonspecific immunity, thus affecting its growth and survival [ 31 ]. Therefore, below the pH and nitrite nitrogen stresses, the spotted babylon movement was retarded, the attachment capacity was reduced, and the reverse back appeared.…”

Section: Discussionmentioning

confidence: 99%

Changes in pH and Nitrite Nitrogen Induces an Imbalance in the Oxidative Defenses of the Spotted Babylon (Babylonia areolata)

Ding,

Yang,

et al. 2023

Antioxidants

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In order to reveal the acute toxicity and physiological changes of the spotted babylon (Babylonia areolata) in response to environmental manipulation, the spotted babylon was exposed to three pH levels (7.0, 8.0 and 9.0) of seawater and four concentrations of nitrite nitrogen (0.02, 2.7, 13.5 and 27 mg/L). The activities of six immunoenzymes, superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (CAT), acid phosphatase (ACP), alkaline phosphatase (AKP) and peroxidase (POD), were measured. The levels of pH and nitrite nitrogen concentrations significantly impacted immunoenzyme activity over time. After the acute stress of pH and nitrite nitrogen, the spotted babylon appeared to be unresponsive to external stimuli, exhibited decreased vigor, slowly climbed the wall, sank to the tank and could not stand upright. As time elapsed, with the extension of time, the spotted babylon showed a trend of increasing and then decreasing ACP, AKP, CAT and SOD activities in order to adapt to the mutated environment and improve its immunity. In contrast, POD and GSH-PX activities showed a decrease followed by an increase with time. This study explored the tolerance range of the spotted babylon to pH, nitrite nitrogen, and time, proving that external stimuli activate the body’s immune response. The body’s immune function has a specific range of adaptation to the environment over time. Once the body’s immune system was insufficient to adapt to this range, the immune system collapsed and the snail gradually died off. This study has discovered the suitable pH and nitrite nitrogen ranges for the culture of the spotted babylon, and provides useful information on the response of the snail’s immune system.

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Section: Discussionmentioning

confidence: 99%

Changes in pH and Nitrite Nitrogen Induces an Imbalance in the Oxidative Defenses of the Spotted Babylon (Babylonia areolata)

Ding,

Yang,

et al. 2023

Antioxidants

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“…The gut microbiota is extensively distributed and plays an integral part in numerous physiological processes of the host in vertebrates (Bletz et al, 2016;Liu et al, 2022;Niu et al, 2022;Yi et al, 2019). However, numerous current researches on gut microbiota have mainly focused on mammals, up to now, far too little attention has been paid to exploring amphibians to a certain extent (Bolnick et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Changes on the Gut Microbiota of <italic>Cynops orientalis</italic>

WANG,

XIE,

et al. 2024

AHR

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The gut microbiota plays a pivotal role in the maintenance of health for amphibians, and it has been fully recognized, but the effectiveness of various influencing factors has not yet been fully clarified. Although this association should be considered while the amphibian order Caudata is facing a severe situation of population decline and extinction, there is little understanding of the association between diets and the diversity of gut microbiota in the amphibian order Caudata. Here, we conducted an extensive analysis of the gut microbiota of Cynops orientalis fed different diets using functional prediction and 16S rRNA amplicon sequencing techniques. First, we found that wild individuals had greater gut microbial diversity and richness in comparison to captive individuals. Second, we identified the bacterial taxa associated with diets and observed differences in the relative abundance of gut microbiota among people on various diets. Finally, we have a predictive comprehension of the selection and adaptative significance of shared core ASVs in the gut microbiota in maintaining the healthy survival of C. orientalis in a large-scale spatiotemporal map. Our study emphasizes how diets alter the gut microbiota of Caudata and offers fresh perspectives on the conservation and captive management of species in Caudata.

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Effects of nitrite exposure on biochemical parameters and liver histopathology in American bullfrogs (Aquarana catesbeiana)

Chen,

Zheng,

Kumar

et al. 2024

Aquacult Int

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Intestinal changes associated with nitrite exposure in Bufo gargarizans larvae: Histological damage, immune response, and microbiota dysbiosis

Cited by 5 publications

References 58 publications

Changes in pH and Nitrite Nitrogen Induces an Imbalance in the Oxidative Defenses of the Spotted Babylon (Babylonia areolata)

Changes in pH and Nitrite Nitrogen Induces an Imbalance in the Oxidative Defenses of the Spotted Babylon (Babylonia areolata)

Effects of Dietary Changes on the Gut Microbiota of <italic>Cynops orientalis</italic>

Effects of nitrite exposure on biochemical parameters and liver histopathology in American bullfrogs (Aquarana catesbeiana)

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Intestinal changes associated with nitrite exposure in Bufo gargarizans larvae: Histological damage, immune response, and microbiota dysbiosis

Cited by 5 publications

References 58 publications

Changes in pH and Nitrite Nitrogen Induces an Imbalance in the Oxidative Defenses of the Spotted Babylon (Babylonia areolata)

Changes in pH and Nitrite Nitrogen Induces an Imbalance in the Oxidative Defenses of the Spotted Babylon (Babylonia areolata)

Effects of Dietary Changes on the Gut Microbiota of &lt;italic&gt;Cynops orientalis&lt;/italic&gt;

Effects of nitrite exposure on biochemical parameters and liver histopathology in American bullfrogs (Aquarana catesbeiana)

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Effects of Dietary Changes on the Gut Microbiota of <italic>Cynops orientalis</italic>