Abstract:The intestinal immune system is constantly exposed to a plethora of antigens (Ags) from innocuous ingested material and the commensal flora that must be distinguished from pathogen-derived antigens. To this end, a number of anatomic, cellular and molecular mechanisms operate in the intestinal tract to acquire, process, present and interpret Ags from the intestinal lumen. The intestinal mucosa is also populated by a large number of T cells that reside within the epithelial lining (intraepithelial lymphocytes, I… Show more
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