Intestinal Blood Flow at Various Intraluminal Pressures in the Piglet with Closed Abdomen

Ruf, Wolfgang; Suehiro, Glenn T.; Suehiro, Anthony; Pressler, Virginia; McNamara, John J.

doi:10.1097/00000658-198002000-00005

Cited by 54 publications

(25 citation statements)

References 7 publications

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“…In 14 other animals (aged 2 weeks and 1 month), an artery supplying the jejunum and one supplying the ileum were exposed through a ventral midline incision, an electromagnetic flow transducer was placed around each vessel, and the incision was closed with wound clips. All animals were given atro pine (0.5 mg/kg every hour) to minimize the effects of intestinal intraluminal pressure on blood flow [23]. Intestinal vascular resistance (MVR for entire intes tine.…”

Section: Procedures For the Intestinal Circulation Studiesmentioning

confidence: 99%

Intestinal and Femoral Blood Flow Autoregulation in Developing Swine

1986

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Pressure-flow relationships (P/F) in the small intestine or hindlimb circulation were used to examine autoregulation in 104 swine, aged 1 day to 2 months and anesthetized with pentobarbital. The P/F were obtained while perfusion pressure was decreased by compression of the abdominal aorta for 2 min at each pressure. Readjustments in vascular resistance stabilized within 2 min. Intestinal flow decreased with each decrease in pressure in swine 2 weeks old or younger, but was well maintained by 1 month of age. Femoral flow decreased with each decrease in pressure at all ages studied. Control experiments indicated that the observed vascular responses were independent of angiotension-II activity and were not reflex in origin.

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Section: Procedures For the Intestinal Circulation Studiesmentioning

confidence: 99%

Intestinal and Femoral Blood Flow Autoregulation in Developing Swine

1986

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“…The lesions were enlarged by the reduction in the blood flow of the microcirculation caused by distention of the colon 12. However, infusion of a foreign substance into the microcirculation of the colon in animals may not reflect the process of thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats

Yano

Yao

Aoyagi

et al. 1997

Gut

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Background-Recent clinical studies suggest that ischaemic colitis is caused by a microcirculatory disturbance that involves thrombosis of the colon. Aim-To establish a new model of photochemically induced ischaemic colitis in rats. Methods-Thirty male Wistar rats were anaesthetised with amobarbital, the femoral veins were cannulated and laparotomies were performed. The serosal surface of the proximal colon was irradiated by using a krypton laser (wavelength 568 nm, 20 mW) for four minutes. An intravenous infusion of a photosensitising dye, rose bengal (20 mg/kg body weight), was administered over 90 seconds, beginning at the start of irradiation. Rats were killed immediately (n=4), 12 hours (n=2), 24 hours (n=10), three days (n=4), seven days (n=4), 14 days (n=2), or 28 days (n=2) after irradiation. Two control rats received laser irradiation without dye infusion. Specimens of the irradiated sites were examined by using histopathology. Results-Localised ulcers of the colon were present in rats killed at 12 hours, 24 hours, three days, and seven days after irradiation. Microscopy findings were consistent with the features of human ischaemic colitis. Reproducible ulcerative lesions were produced by photothrombosis of microvessels in the colon. Conclusion-This model may be useful for further investigation of the pathophysiology of ischaemic colitis.

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“…A decrease in arterial blood flow is a direct result of small bowel obstruction. A negative correlation exists between bowel diameter, intraluminal pressure, and blood flow [18][19][20], Strodahl et al [ 18] showed a decreased blood flow to 10% of normal values in a closed loop guinea pig bowel prepa ration after contrast medium injection. The appearance of Gastrografin in the urinary tract has been considered a sign of a break in the intestinal mucosa, as proven in experimental animal models [21].…”

Section: Discussionmentioning

confidence: 99%

Role of Gastrografin in the Management of Small Bowel Obstruction: A Study of 355 Cases

Avrahami¹,

Kalish²,

Wattemberg³

et al. 1996

Dig Surg

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The effect of Gastrografin on the management of small bowel obstruction was evaluated retrospectively. A total of 355 patients with small bowel obstruction (excluding those with abdominal wall hernia) formed the study population: 219 (61.7%) were treated conservatively without Gastrografin, and 136 (38.3%) were treated conservatively with Gastrografin. Of the first group, 26.0% required surgery as compared with 9.5% of the second group (p < 0.05). After exclusion of those patients who underwent surgery during the first 24 h because of complete obstruction or progressive deterioration in their condition (15 and 3, respectively), surgical treatment was needed in 19% of those who were treated without Gastrografin versus only 7.3% in those who received Gastrografin (p < 0.05). The use of Gastrografin may reduce the need for surgery in patients with small bowel obstruction, without increasing complication rates.

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Intestinal Blood Flow at Various Intraluminal Pressures in the Piglet with Closed Abdomen

Cited by 54 publications

References 7 publications

Intestinal and Femoral Blood Flow Autoregulation in Developing Swine

Intestinal and Femoral Blood Flow Autoregulation in Developing Swine

Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats

Role of Gastrografin in the Management of Small Bowel Obstruction: A Study of 355 Cases

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