Intestinal barrier integrity in patients with plaque psoriasis

Sikora, Mariusz; Chrabąszcz, Magdalena; Maciejewski, Cezary; Zaremba, Michał; Waśkiel, Anna; Olszewska, Małgorzata; Rudnicka, Lidia

doi:10.1111/1346-8138.14647

Cited by 53 publications

(49 citation statements)

References 14 publications

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“…The results of the present study confirm and expand our previous results that psoriasis is associated with disruption of the gastrointestinal barrier …”

Section: Discussionsupporting

confidence: 92%

Claudin‐3 – a new intestinal integrity marker in patients with psoriasis: association with disease severity

Sikora

Chrabąszcz

Waśkiel‐Burnat

et al. 2019

Acad Dermatol Venereol

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Background Gut dysbiosis and increased intestinal permeability play a significant role in the pathogenesis of psoriasis and its comorbidities. Claudin-3 is a key component of tight junctions, which may serve as marker of gut barrier integrity.Objectives The aim of the study was to investigate circulating plasma claudin-3 in patients with psoriasis and to evaluate clinical and metabolic factors, which determine its concentration.Methods This cross-sectional study included 60 patients with psoriasis (39 men and 21 women, mean age: 45.6 AE 12.1 years) and 30 healthy controls (18 men and 12 women, mean age: 46.3 AE 15.5 years) age, sex and body mass index-matched. Plasma claudin-3 concentration was measured using an enzyme-linked immunosorbent assay.Results Plasma claudin-3 concentration was significantly higher in patients with psoriasis in comparison with healthy control [median (interquartile range), 50.7 ng/mL (47.3-54.2) vs. 43.3 ng/mL (42.3-44.2), P < 0.001]. Patients who achieved DPASI90 response after 16 weeks of treatment showed tendency to decrease in circulating claudin-3 plasma concentration. Positive correlations between claudin-3 concentration and the PASI score (r = 0.828; P < 0.001) as well as claudin-3 and neutrophil-to-lymphocyte ratio (r = 0.847; P < 0.001) were found. A multivariable linear regression analysis confirmed association of claudin-3 with the PASI score (P < 0.001), neutrophil-to-lymphocyte ratio (P < 0.01) and active smoking (P < 0.05).Conclusion Claudin-3, a biomarker for gut permeability, is increased in psoriasis and correlates with disease severity and smoking. Further investigations are needed to determine whether reinforcing intestinal barrier may be a new therapeutic target in psoriasis.

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“…The results of the present study confirm and expand our previous results that psoriasis is associated with disruption of the gastrointestinal barrier …”

Section: Discussionsupporting

confidence: 92%

Claudin‐3 – a new intestinal integrity marker in patients with psoriasis: association with disease severity

Sikora

Chrabąszcz

Waśkiel‐Burnat

et al. 2019

Acad Dermatol Venereol

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“…Furthermore, alterations in the composition of gut microbiome have been observed in patients with psoriasis. A decrease in phylum of Actinobacteria , which includes Bifidobacterium species of a known immunosuppressive activity, and perturbations in the balance of Firmicutes and Bacteroidetes , along with recent findings of an increased intestinal permeability, supports a new concept of a “gut‐skin axis” in psoriasis …”

Section: Changes Of the Hair Follicle Microbiome In Scalp Diseasesmentioning

confidence: 70%

The role of the microbiome in scalp hair follicle biology and disease

Polak-Witka

Rudnicka

Blume-Peytavi

et al. 2019

Experimental Dermatology

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The skin surface microbiome and its role in skin diseases have received increasing attention over the past years. Beyond, there is evidence for a continuous exchange with the cutaneous immune system in healthy skin, where hair follicles (HFs) provide unique anatomical niches. Especially, scalp HFs form large tubular invaginations, which extend deeply into the skin and harbour a variety of microorganisms. The distinct immunology of HFs with enhanced immune cell trafficking in superficial compartments in juxtaposition to immune‐privileged sites crucial for hair follicle cycling and regeneration makes this organ a highly susceptible structure. Depending on composition and penetration depth, microbiota may cause typical infections, but may also contribute to pro‐inflammatory environment in chronic inflammatory scalp diseases. Involvement in hair cycle regulation and immune cell maturation has been postulated. Herein, we review recent insights in hair follicle microbiome, immunology and penetration research and discuss clinical implications for scalp health and disease.

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“…Alterations in gut microflora may also lead to intestinal barrier disintegration. Higher levels of claudin‐3 and intestinal fatty acid binding protein, the markers of intestinal barrier damage, were noticed among patients with psoriasis …”

Section: Methodsmentioning

confidence: 99%

“…Higher levels of claudin-3 and intestinal fatty acid binding protein, the markers of intestinal barrier damage, were noticed among patients with psoriasis. 55 The studies concerning the coexistence of SIBO with psoriasis remain contradictory. Nevertheless, SIBO eradication has been associated with cutaneous lesions amelioration.…”

Section: Psoriasis and Psoriatic Arthritismentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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Intestinal barrier integrity in patients with plaque psoriasis

Cited by 53 publications

References 14 publications

Claudin‐3 – a new intestinal integrity marker in patients with psoriasis: association with disease severity

Claudin‐3 – a new intestinal integrity marker in patients with psoriasis: association with disease severity

The role of the microbiome in scalp hair follicle biology and disease

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

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