Intestinal barrier functions in hematologic and oncologic diseases

Haroun, Elio; Kumar, Prashanth Ashok; Saba, Ludovic; Kassab, Joseph; Ghimire, Krishna Bilas; Dutta, Dibyendu; Lim, Seah H.

doi:10.1186/s12967-023-04091-w

Cited by 4 publications

(2 citation statements)

References 140 publications

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“…Due to chronic ischemia-reoxygenation damage induced by VOC, patients with SCD may suffer from leaky gut, which affects microbiota density and adhesion to the epithelial wall and the degree of translocation [ 155 ]. This influences nutrient intake, metabolic homeostasis, hormonal environment, microbiota imbalance, and immunity [ 156 ].…”

Section: Nutritional Perspectives In Sickle Cell Diseasementioning

confidence: 99%

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell,

Varzakas,

Psaltopoulou

et al. 2024

Nutrients

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Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a congenital blood disorder characterized by considerable phenotypic diversity. It comprises a group of disorders, with sickle cell anemia (SCA) being the most prevalent and serious genotype. Although there have been some systematic reviews of global data, worldwide statistics regarding SCD prevalence, morbidity, and mortality remain scarce. In developed countries with a lower number of sickle cell patients, cutting-edge technologies have led to the development of new treatments. However, in developing settings where sickle cell disease (SCD) is more prevalent, medical management, rather than a cure, still relies on the use of hydroxyurea, blood transfusions, and analgesics. This is a disease that affects red blood cells, consequently affecting most organs in diverse manners. We discuss its etiology and the advent of new technologies, but the aim of this study is to understand the various types of nutrition-related studies involving individuals suffering from SCD, particularly in Africa. The interplay of the environment, food, gut microbiota, along with their respective genomes collectively known as the gut microbiome, and host metabolism is responsible for mediating host metabolic phenotypes and modulating gut microbiota. In addition, it serves the purpose of providing essential nutrients. Moreover, it engages in direct interactions with host homeostasis and the immune system, as well as indirect interactions via metabolites. Nutrition interventions and nutritional care are mechanisms for addressing increased nutrient expenditures and are important aspects of supportive management for patients with SCD. Underprivileged areas in Sub-Saharan Africa should be accompanied by efforts to define and promote of the nutritional aspects of SCD. Their importance is key to maintaining well-being and quality of life, especially because new technologies and products remain limited, while the use of native medicinal plant resources is acknowledged.

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Section: Nutritional Perspectives In Sickle Cell Diseasementioning

confidence: 99%

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell,

Varzakas,

Psaltopoulou

et al. 2024

Nutrients

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“…Several external factors, including bacteria, affect intestinal permeability. Furthermore, the primary pathogen in piglets is E. coli, which causes an increase in the gut permeability [41]. Acute and persistent diarrhea are associated with increased intestinal permeability, and repeated diarrhea results in malnutrition [42].…”

Section: Paracellular Permeabilitymentioning

confidence: 99%

Antimicrobial Activity of Pediococcus pentosaceus Strains against Diarrheal Pathogens Isolated from Pigs and Effect on Paracellular Permeability of HT-29 cells

Cho,

Yoo,

Yoon

2024

J Anim Sci Technol

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Effect of preoperative oral nutritional supplements on clinical outcomes in patients undergoing surgery for gastrointestinal cancer: A systematic review and meta-analysis

Zou,

Yin,

Ding

et al. 2024

Medicine

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Background: The clinical benefit of preoperative oral nutritional supplements (ONS) in patients undergoing surgery for gastrointestinal cancer remains controversial. Objective: To evaluate the effect of preoperative ONS on postoperative clinical outcomes in patients with gastrointestinal cancer. Methods: We searched PubMed, EMBASE, Web of Science, Cochrane Library, Scopus, and the Chinese National Knowledge Infrastructure databases for randomized controlled trials evaluating preoperative ONS in patients undergoing surgery for gastrointestinal cancer from inception until April 2024. Two researchers independently assessed the quality of the included literature and performed statistical analyses using Review Manager 5.4 software. Results: A total of 12 eligible studies with 1201 patients (600 ONS group and 601 control group) were included in this meta-analysis. Compared with a normal diet, preoperative ONS effectively reduced infectious complications (odds ratio = 0.63; 95% confidence interval [CI], 0.40–0.98; P = .04), white blood cell count (mean difference [MD] = −0.66; 95% CI, −1.04 to −0.28; P = .0007), C-reactive protein (MD = −0.26; 95% CI, −0.33 to −0.19; P < .00001), and markedly improved albumin levels (MD = 1.71; 95% CI, 0.97–2.46; P < .00001), prealbumin (MD = 24.80; 95% CI, 1.72–47.88; P = .04), immunoglobulin G (MD = 0.86; 95% CI, 0.44–1.28; P < .00001), CD4 T lymphocyte cells (MD = 3.06; 95% CI, 2.21–3.92; P < .00001), and CD4 T lymphocyte cells/CD8 T lymphocyte cells (MD = 0.33; 95% CI, 0.10–0.56; P = .004). However, there were no significant differences between the 2 groups in terms of noninfectious complications (odds ratio = 0.77; 95% CI, 0.39–1.53; P = .46), immunoglobulin A (MD = −0.21; 95% CI, −0.44 to 0.02; P = .08) or length of hospital stay (MD = −0.04; 95% CI, −0.71 to 0.64; P = .92). Conclusion: Preoperative ONS may effectively reduce postoperative infectious complications, improve postoperative nutritional status and immune function, and relieve the inflammatory response in gastrointestinal cancer patients. Therefore, we recommend that preoperative nutrition could be optimized with ONS in patients undergoing gastrointestinal cancer surgery.

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Intestinal barrier functions in hematologic and oncologic diseases

Cited by 4 publications

References 140 publications

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Antimicrobial Activity of Pediococcus pentosaceus Strains against Diarrheal Pathogens Isolated from Pigs and Effect on Paracellular Permeability of HT-29 cells

Effect of preoperative oral nutritional supplements on clinical outcomes in patients undergoing surgery for gastrointestinal cancer: A systematic review and meta-analysis

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