Intestinal barrier dysfunction is involved in the development of systemic inflammatory responses and lung injury in type A aortic dissection: a case-control study

Lǐ, Jiànróng; Zheng, Jianhua; Jin, Xiufeng; Zhu, K. J.; Wang, Xiaolong; Zhang, Hongjia

doi:10.21037/jtd-22-1122

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…IL-6 and TNF-α are markers of immune activation and have been implicated in signalling immune reactions during the PSD process. These cytokines may also interact with iFABP, potentially leading to gut permeability and subsequent immune and inflammatory responses [13] [14] . David et al [15] demonstrated that patients with spinal cord injuries have elevated levels of IL-6, TNF-α, and iFABP, which are associated with increased gut barrier damage.…”

Section: Introductionmentioning

confidence: 99%

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Wang¹,

Chen²,

Zhu³

et al. 2023

J Med Biochemistry

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Background: To investigate the expression levels of blood biomarkers interleukin-6 (IL-6), tumor necrosis factor (TNF-α), and intestinal fatty acid binding protein (iFABP) in patients with post-stroke depression (PSD), and their correlation with PSD occurrence. Methods: Clinical data of stroke patients admitted to the First People’s Hospital of Wenling from December 2017 to December 2022 were retrospectively analyzed. Patients were classified into two groups based on their Hamilton Depression Rating Scale (HAMD) scores: PSD and non-PSD groups. The blood levels of IL-6, TNF-α, and iFABP were compared between the two groups, and their association with PSD occurrence was analyzed. Results: The PSD group had significantly higher levels of IL-6, TNF-α, and iFABP. The combined detection of these biomarkers demonstrated a greater predictive value for PSD occurrence compared to the individual detection of each biomarker. Conclusion: The study indicates that the levels of IL-6, TNF-α, and iFABP in the blood are significantly increased in patients with PSD. The combined detection of these biomarkers can effectively predict the occurrence of PSD, indicating high clinical value.

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Section: Introductionmentioning

confidence: 99%

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Wang¹,

Chen²,

Zhu³

et al. 2023

J Med Biochemistry

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Perioperative oxygenation impairment related to type a aortic dissection

Liu,

Guan,

Yang

et al. 2024

Perfusion

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Type A aortic dissection (TAAD) is a life-threatening disease with high mortality and poor prognosis, usually treated by surgery. There are many complications in its perioperative period, one of which is oxygenation impairment (OI). As a common complication of TAAD, OI usually occurs throughout the perioperative period of TAAD and requires prolonged mechanical ventilation (MV) and other supportive measures. The purpose of this article is to review the risk factors, mechanisms, and treatments of type A aortic dissection-related oxygenation impairment (TAAD-OI) so as to improve clinicians’ knowledge about it. Among risk factors, elevated body mass index (BMI), prolonged extracorporeal circulation (ECC) duration, higher inflammatory cells and stored blood transfusion stand out. A reduced occurrence of TAAD-OI can be achieved by controlling these risk factors such as suppressing inflammatory response by drugs. As for its mechanism, it is currently believed that inflammatory signaling pathways play a major role in this process, including the HMGB1/RAGE signaling pathway, gut-lung axis and macrophage, which have been gradually explored and are expected to provide evidences revealing the specific mechanism of TAAD-OI. Numerous treatments have been investigated for TAAD-OI, such as nitric oxide (NO), continuous pulmonary perfusion/inflation, ulinastatin and sivelestat sodium, immunomodulation intervention and mechanical support. However, these measures are all aimed at postoperative TAAD-OI, and not all of the therapies have shown satisfactory effects. Treatments for preoperative TAAD-OI are not currently available because it is difficult to correct OI without correcting the dissection. Therefore, the best solution for preoperative TAAD-OI is to operate as soon as possible. At present, there is no specific method for clinical application, and it relies more on the experience of clinicians or learns from treatments of other diseases related to oxygenation disorders. More efforts should be made to understand its pathogenesis to better improve its treatments in the future.

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Intestinal barrier dysfunction is involved in the development of systemic inflammatory responses and lung injury in type A aortic dissection: a case-control study

Cited by 2 publications

References 26 publications

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Perioperative oxygenation impairment related to type a aortic dissection

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