Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice

Abstract

Sphingolipids appear as a promising class of components susceptible to prevent the onset of the metabolic syndrome (MetS). Gut availability and effects of Camelina sativa sphingolipids were investigated in a mouse model of dietary-induced metabolic syndrome. Seed meals from two Camelina sativa lines enriched respectively in C24-and C16-NH 2-glycosyl-inositolphosphoryl-ceramides (NH 2 GIPC) were used in hypercaloric diets. After 5 weeks on these two hypercaloric diets, two markers of the MetS were alleviated (adiposity and insulin resistance) as well as inflammation markers and colon barrier dysfunction. A more pronounced effect was observed with the C16-NH 2 GIPC-enriched HC diet, in particular for colon barrier function. Despite a lower digestibility, C16-NH 2 GIPC were more prevalent in the intestine wall. Sphingolipids provided as camelina meal can therefore counteract some deleterious effects of a hypercaloric diet in mice at the intestinal and systemic levels.Interestingly, these beneficial effects seem partly dependent on sphingolipid acyl chain length.

Speculation of Sphingolipids in Capsanthin by Ultra-Performance Liquid Chromatography Coupled with Electrospray Ionization-Quadrupole—Time-of-Flight Mass Spectrometry

“…Sphingolipids are a class of lipids existing in all living organisms as the important structural components of membranes. Plenty of research shows that sphingolipids play key roles in regulating the growth, differentiation, migration, and apoptosis of cells and the immune system in many mammalian cells [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Ceramides are a group of sphingolipids composed of sphingosine and a fatty acid via an amide linkage.…”

Shift of Volatile Organic Compounds (VOCs) in Gluten-Free Hemp-Enriched Sourdough Bread: A Metabolomic Approach

“…[23,[41][42][43] ∆-3-carene harsh, terpene-like, coniferous active against spoilage microbes, food-borne pathogens, and pathogenic E. coli. [31,44,45] β-caryophillene oxide dry, wood, cedarwood, carrot anti-inflammatory and analgesic effects in different mouse models of inflammatory pain; antibacterial capacity versus Helicobacter pylori.…”

“…[31, [46][47][48] β-caryophillene woody-spicy, dry and tenacious known as "dietary cannabinoid", it has been shown to be orally bioavailable; C. sativa essential oils bearing up to 13% of this compounds is effective against several opportunistic and spoilage microorganisms including Helicobacter pylori; prevents structural alteration of the myocardium; effective against LPS-induced oligodendrocyte toxicity; prevention of lipid accumulation and improvement of glucose uptake; insulinotropic and antidiabetic effects [31,34,[48][49][50][51][52][53] Eicosene (E) is a part constituting ceramide (Sphingosine); cardioprotective effects; on mouse model can be effective on treating metabolic disorder; in human plasma binds to high-density lipoprotein and exhibit anti-atherogenic properties [45,54,55] 1-pentanone-3-hydroxy caramel-sweet, buttery, and hay-like is converted during glycosylation of toxic furanones [56] propanoic acid typical sharp, acrid, vinegar, sour taste Inhibition of ubiquitous bacilli, spoilage microbes and food-borne pathogens; prebiotics; fostering of the selective growth of probiotics in the gut; stimulation of epithelial immune function [18,23,57,58] lactic acid sharp, acrid, vinegar, sour taste buttery nuance inhibition of ubiquitous bacilli, spoilage microbes and food-borne pathogens [18,23,57] hexanoic acid rancid-like inhibition of molds in bread [23,59] heptanoic acid rancid-like [23] octanoic acid rancid-like binding to -OH of serine residues of ghrelin activate the hormone and regulate hunger; in combination to antioxidant compounds produces esters lipophenols that have stronger and more stable host antioxidant activity; [23,[59][60][61] nonanoic acid fatty, waxy, and cheesy with a mild sweet creamy background effective on excessive calorie burning, inducing weight loss [18,2...…”