Intestinal associations of a single umbilical artery

McMurran, A E L; McMahon, Suzanne; Walker, Gregor

doi:10.1136/archdischild-2014-307582

Cited by 3 publications

(3 citation statements)

References 4 publications

(3 reference statements)

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“…In 10–27% of cases of SUA, it is combined with other fetal malformations, and a strong association with trisomy 18 has been found. SUA is associated with an increased risk of chromosomal aberrations and congenital malformations in the fetus. These malformations have been reported to occur in most organ systems, but reported findings have not been consistent.…”

Section: Introductionmentioning

confidence: 99%

“…SUA is associated with an increased risk of chromosomal aberrations and congenital malformations in the fetus. These malformations have been reported to occur in most organ systems, but reported findings have not been consistent. The association of SUA with malformations may point to its developmental origin, and, therefore, a study of SUA and associated congenital malformations is of interest.…”

Section: Introductionmentioning

confidence: 99%

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Single umbilical artery and risk of congenital malformation: population‐based study in Norway

Ebbing

Kessler

Moster

et al. 2020

Ultrasound in Obstet & Gyne

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Objectives Single umbilical artery (SUA) is associated with congenital malformations in most organ systems, but reported findings have not been consistent. While it has been suggested that genetic and persisting environmental factors influence the development of SUA, it is not known whether there is an increased risk of recurrence in a subsequent pregnancy of the same woman. The aims of this study were to investigate the occurrence of, and risk factors for, SUA in Norway, to assess its association with congenital malformations and trisomies 13, 18 and 21 and to study the risk of recurrence of SUA in subsequent pregnancies. Methods This was a population‐based study of all (n = 918 933) singleton pregnancies of > 16 weeks' gestation recorded in the Medical Birth Registry of Norway from 1999 to 2014. To identify risk factors and congenital malformations associated with SUA, generalized estimating equations and logistic regression were used to calculate odds ratios (OR) with 95% CIs. ORs were also calculated for the recurrence of SUA in subsequent pregnancy. Results The occurrence of SUA in our population was 0.46% (4241/918 933). Parity ≥ 4, smoking, maternal pregestational diabetes, epilepsy, chronic hypertension, previous Cesarean delivery and conception by assisted reproductive technology increased the odds of having SUA. There was a particularly strong association between SUA and gastrointestinal atresia or stenosis in the neonate, with ORs of 25.8 (95% CI, 17.0–39.1) and 20.3 (95% CI, 13.4–30.9) for esophageal and anorectal atresia or stenosis, respectively, followed by an OR of 5.9 (95% CI, 1.9–18.5) for renal agenesis. SUA was associated with an up to 7–8 times increased risk of congenital heart defects. There was an association with microcephaly, congenital hydrocephalus and other congenital malformations of the brain and spinal cord. Diaphragmatic hernia, limb reductions and cleft lip or palate had a weaker association with SUA, with ORs ranging from 4.8 to 2.8. The associations with trisomy 18 and 13 were equally strong (OR 14.4 (95% CI, 9.3–22.4) and OR 13.6 (95% CI, 6.7–27.8), respectively), and the risk of trisomy 21 was doubled (OR 2.1 (95% CI, 1.2–3.6)). Pregnancies with SUA, with or without an associated malformation, had a 2‐fold increased risk for SUA in a subsequent pregnancy. Conclusions SUA is associated strongly with gastrointestinal atresia or stenosis, suggesting common developmental mechanisms. The increased risk of recurrence of SUA suggests that genetic and/or persisting environmental factors influence the risk. We found that SUA had equally strong associations with trisomies 13 and 18. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Single umbilical artery and risk of congenital malformation: population‐based study in Norway

Ebbing

Kessler

Moster

et al. 2020

Ultrasound in Obstet & Gyne

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“…At this time there are approximately 25 cases of ileal atresia associated with Hirschsprung’s disease4–9 and one case of an oesophageal abnormality associated with Hirschsprung’s disease10 reported in the literature. However, as far as we know, there are no reports of oesophageal anomalies associated with Hirschsprung’s disease and/or ileal atresia.…”

Section: Introductionmentioning

confidence: 99%

Oesophageal atresia with tracheo-oesophageal fistula, ileal atresia and Hirschsprung’s disease: outcome of a rare phenotype

Santos¹,

Coimbra

Cunha

et al. 2019

BMJ Case Rep

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Oesophageal atresia with or without tracheo-oesophageal fistula, ileal atresia and Hirschsprung’s disease are surgical malformations of the gastrointestinal tract typically diagnosed early in the neonatal period and varying in severity and prognosis. This report describes a full-term male newborn presenting simultaneous oesophageal atresia with distal tracheo-oesophageal fistula, ileal atresia and Hirschsprung’s disease. In addition to the complex types of gastrointestinal malformations involved, the combination of ileal atresia and Hirschsprung’s disease, as well as ganglion cells distal to intestinal atresia, resulted in a challenging diagnosis. Despite a successful outcome, the patient presented increased morbidity and prolonged hospitalisation. We highlight some important findings that may aid the early diagnosis of Hirschsprung’s disease in this clinical setting. To our knowledge, the association of oesophageal atresia/tracheo-oesophageal fistula, ileal atresia and Hirschsprung’s disease has not been previously reported.

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Interventions for the Management of Respiratory Distress in Late Preterm and Term Infants Experiencing Delayed Respiratory Transition

Bedwell

Leasure

Gibson

2019

Dimens Crit Care Nurs

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Objectives To examine the best available evidence for interventions used to manage mild to moderate respiratory distress in late preterm and term infants experiencing delayed respiratory transition. Data Sources EMBASE, MEDLINE, Cochrane Review, Joanna Briggs, PubMed, CINAHL, and Google Scholar online databases were searched for articles related to delayed respiratory transition. Reference lists were reviewed to identify additional articles for inclusion. Study Selections Randomized, blinded, placebo-controlled, randomized prospective, prospective observational, and retrospective cohort studies published in English-language, peer-reviewed journals between 2007 and August 2017 were reviewed for inclusion. Studies were included if they examined respiratory focused interventions that could potentially prevent admission to the neonatal intensive care unit (NICU) of the term or late preterm infant transitioning to extrauterine life. Data Extraction The CASP tools were utilized for appraisal of individual studies. Data were extracted from the 5 studies included in this review. Data Synthesis In 4 of the 5 studies, prevention of NICU admission was the primary aim. The observational study observed videos of newborn resuscitations and described the effect of early intervention with continuous positive-airway pressure (CPAP) ventilation on prevention of NICU admission for respiratory distress. One randomized controlled trial used adrenaline injections to prevent development of respiratory distress. The 3 remaining randomized controlled trials used prophylactic CPAP or sustained inflation as a method for preventing development of delayed respiratory transition. Three of the 5 studies focused exclusively on cesarean born infants. Among the interventions studied, early or prophylactic CPAP shows the most promise for prevention of NICU admission in late preterm and term infants with mild to moderate respiratory distress. Conclusion The lack of safety and efficacy data for either adrenaline injections or prophylactic CPAP precludes either method for current use in the prevention of respiratory distress for the late preterm or term infant transitioning to extrauterine life. Two randomized trials, both using prophylactic CPAP, had a significant decrease in NICU admissions. Both studies were conducted at a single center and exclusive to infants born by cesarean delivery. A single study using sustained lung inflation showed no significant difference in the need for respiratory support or NICU admission. A single study using adrenaline also showed no benefit to the prevention of respiratory distress related to transition. Further multicenter randomized controlled trials are needed before broad adoption of early or prophylactic CPAP can be recommended.

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Intestinal associations of a single umbilical artery

Cited by 3 publications

References 4 publications

Single umbilical artery and risk of congenital malformation: population‐based study in Norway

Single umbilical artery and risk of congenital malformation: population‐based study in Norway

Oesophageal atresia with tracheo-oesophageal fistula, ileal atresia and Hirschsprung’s disease: outcome of a rare phenotype

Interventions for the Management of Respiratory Distress in Late Preterm and Term Infants Experiencing Delayed Respiratory Transition

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