Intestinal anti‐inflammatory activity of morin on chronic experimental colitis in the rat

Abstract

In¯ammatory bowel disease is a chronic disease of the digestive tract, and usually refers to two related conditions, namely ulcerative colitis and Crohn's disease. The aetiology of in¯ammatory bowel disease remains unknown, although it is believed that an alteration in the intestinal immune system contributes to the in¯ammation that occurs. As in other in¯am-matory processes, in¯ammatory bowel disease is characterized by an up-regulation in the synthesis and release of different pro-in¯ammatory mediators, including reactive oxygen and nitrogen metabolites, eicosanoids, platelet-activating factor and cytokines. 1 All of these mediators contribute to the pathogenic cascade that initiates and perpetuates the in¯ammatory response of the gut. As a consequence, and until its aetiology has been completely elucidated, the best strategy to effectively down-regulate intestinal in¯ammation is to interfere with multiple stages of the in¯ammatory cascade, preferably with a single drug treatment. In fact, the SUMMARY Background: Morin, a bio¯avonoid with antioxidant properties, shows intestinal anti-in¯ammatory activity in the acute phase of the trinitrobenzenesulphonic acid model of rat colitis. Aim: To assess the anti-in¯ammatory activity of morin in the chronic stages of trinitrobenzenesulphonic acidinduced rat colitis. Methods: Rats were rendered colitic by a single colonic instillation of 30 mg of the hapten trinitrobenzenesulphonic acid dissolved in 0.25 mL of 50% ethanol. A group of colitic animals was given morin orally at doses of 25 mg/kg daily. Animals were sacri®ced every week for 4 weeks. Colonic damage was evaluated macroscopically and microscopically. Different biochemical markers of colonic in¯ammation were also assayed, including myeloperoxidase activity, leukotriene B 4 and

Morin hydrate promotes inner ear neural stem cell survival and differentiation and protects cochlea against neuronal hearing loss

“…Being yellow crystalline when extracted and purified, morin hydrate has exhibited a wide range of beneficial pharmacological effects, including anti‐cancer 10 and anti‐inflammatory activities 11, xanthine oxidase inhibitor property 12, preventing oxidation of low‐density lipoprotein 13, free radical scavenging activity 14 which in turn prevented DNA damage 15. However, to date, its function in NSC growth and differentiation, as well as in preventing neuronal hearing loss, has yet to be studied.…”

Preventive and Therapeutic Effects Ramulus Mori Extract on Collagen-Induced Arthritis in Mice via Suppression of Inflammatory T Cells

“…It was reported that the constituents of RM possess antiinflammatory and antioxidant parmacologic activities. [3][4][5] We suggest that some of these components may have a synergistic effect on CIA. Further research is needed to determine which fractional extraction of ERM is most effective in CIA mice.…”

“…Morin has excellent antioxidant and antiinflammatory activities and suppresses inflammation induced by macrophages. [3][4][5] MR has immune-adjusting, antihypertensive, antibacterial, analgesic, and antiinflammatory effects and is frequently used to treat hypertension, RA, and diabetes. It promotes the conversion of lymphocytes associated with depressed systemic immunity.…”

Polyphenols and immunity

“…Flavonoids are excellent candidates because of their anti-inflammatory properties and their low toxicity. Several flavonoids have been shown to exert intestinal anti-inflammatory activity in vivo, including (mg/kg) quercitrin 1-5 (1) , rutin 10-25 (2) , morin 25 (3,4) , hesperidin and diosmin 10-25 (5) . However, the mechanism of action is unclear.…”

“…, rutin 10-25 (2) , morin 25 (3,4) , hesperidin and diosmin 10-25 (5) . However, the mechanism of action is unclear.…”