Intestinal adenocarcinomas in three generations of sheep

Løken, T.; Bjørnstad, E. R.; Ersdal, Cecilie

doi:10.1136/vr.100268

Cited by 8 publications

(11 citation statements)

References 13 publications

(21 reference statements)

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“…15 Moreover, amyloid deposition in the kidney is a common finding in domestic animals suffering from a chronic inflammatory disease, such as tuberculosis. 11 Bearing in mind that SIA is the most frequent noninfectious neoplasia in sheep 6 and that it has been already reported in this region of Spain, 13 it is likely that the diagnosis of these 2 rare conditions in the same animal is a coincidence. However, the etiology of SIA is not clear yet, and several hypotheses, such genetic predisposition or carcinogens ingestion, have been proposed to explain such high prevalence of this neoplasia.…”

Section: Discussionmentioning

confidence: 95%

“…7 On the other hand, patients with cancer show increased susceptibility to infections due to several factors, such as disturbances to host immunity, tissue necrosis, or mechanical obstructions. 5 It seems logical to hypothesize as well that, notwithstanding any of those factors, the poor body condition or malnutrition showed by this animal, and usually present in sheep with SIA, 6,13 could have favored the establishment of infectious conditions or the reemergence of such infections from a latent, controlled state because of an inadequate immune status of the host. It is possible then that the disseminated tuberculosis found in this sheep could have appeared as an opportunistic infectious consequence of SIA.…”

Section: Discussionmentioning

confidence: 97%

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Coexistence of Granulomatous Enteric Inflammation and Neoplasia in an Adult Sheep

et al. 2013

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A 7-year-old dairy sheep suffering from chronic loss of weight without diarrhea or anorexia was euthanized after failing to respond to any treatment (antibiotic and antiparasitic). The main findings at the necropsy of this animal were multifocal miliary nodules in several organs, mainly in the Peyer’s patches of the small intestine, and a segmental thickening of the jejunal wall. Histologic examination of the samples taken at the necropsy showed a multifocal chronic granulomatous inflammation, with mineralization and caseous necrosis at the core of the larger granulomas and scarce intrahistiocytic acid-fast bacilli consistent with a disseminated digestive tuberculosis. Polymerase chain reaction and bacteriological culture from these samples confirmed Mycobacterium avium subsp avium to be the etiologic agent of this infection. Histologically, the cause of the segmental thickening of the jejunal wall was found to be a small intestine adenocarcinoma, which in some areas coexisted with the granulomatous lesion.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

Coexistence of Granulomatous Enteric Inflammation and Neoplasia in an Adult Sheep

et al. 2013

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“…Its serosal appearance of a pale grey, firm, annular thickening is typical (Dodd 1960, Cordes and Shortridge 1971, Ross 1980, Løken and others 2012). In this case, the mucosal surface was smooth.…”

Section: Discussionmentioning

confidence: 99%

Intestinal adenocarcinoma in a Shetland ewe

Crilly

Smith

Sargison

2014

Vet Record Case Reports

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“…17,26,39 It is recognized in humans as familial adenomatous polyposis and heritable nonpolyposis colorectal cancer. 13,20 Interestingly, there are marked morphologic similarities between intestinal adenocarcinomas in Sika deer and heritable nonpolyposis colorectal cancer in humans.…”

Section: Discussionmentioning

confidence: 99%

“…3,14,32,52 The ingestion of bracken fern in cattle with contemporaneous bovine papillomavirus infection has been proposed as a cause, 16 while herbicides have been implicated in sheep. 33,52,53 A genetic influence is suspected in Siamese cats, German Shepherd dogs, and some sheep breeds, 17,26,38 while in humans, up to 30% of cases of colorectal cancer have an identifiable familial component. 22 To date, intestinal adenocarcinoma has not been reported in deer.…”

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confidence: 99%

Intestinal Adenocarcinoma in a Herd of Farmed Sika Deer (Cervus nippon)

Toolan¹,

Jahns

2014

Vet Pathol

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Intestinal adenocarcinomas were identified in 76 adult deer from a closed herd of 193 breeding animals grazing pasture heavily infested with bracken fern (Pteridium aquilinum). Tumors were observed postmortem in 32 animals with rapid weight loss, and similar neoplasms were detected in a further 44 clinically normal deer at ''cull.'' Tumors were located in distal ileum, cecum, and proximal colon and presented as single (26%) or multiple (74%), variably sized, pale-gray, firm, poorly circumscribed neoplasms with associated intestinal strictures. Histopathologically tumors were well-differentiated, locally infiltrative, low-grade adenocarcinomas of tubular (51%), mucinous (33.5%), or mixed (15.5%) types. Extraintestinal metastases were not observed. The high incidence of intestinal adenocarcinoma within this herd suggests a specific and novel syndrome, and genetic and/or environmental factors may be involved in the pathogenesis.

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Intestinal adenocarcinomas in three generations of sheep

Cited by 8 publications

References 13 publications

Coexistence of Granulomatous Enteric Inflammation and Neoplasia in an Adult Sheep

Coexistence of Granulomatous Enteric Inflammation and Neoplasia in an Adult Sheep

Intestinal adenocarcinoma in a Shetland ewe

Intestinal Adenocarcinoma in a Herd of Farmed Sika Deer (Cervus nippon)

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