Intestinal Absorption of Lysozyme Molecules and their Destination, an Immunohistochemical Study on Rat.

Immunohistochemical Study on the Secretory Host Defense System of Bactericidal Peptides in Rat Digestive Organs

“…Lysozyme and defensin molecules are strongly cationic charged [6]. In fact, the absorption of orally administrated egg white lysozyme has been confirmed immunohistochemically and immunoelectron-microscopically in the rat small intestine [35]. We observed lysozyme, sPLA2, β-defensin1 and β-defensin2 in the luminal contents and also in the cytoplasm of the epithelial cells at the apices of the intestinal villi.…”

Exogenous lysozyme influencesClostridium perfringenscolonization and intestinal barrier function in broiler chickens

“…For example, oral administration of egg white lysozyme is now used clinically in human medicine for the therapy of inflammatory diseases of respiratory and digestive epithelia (Seno et al, 1998). In rainbow trout, lysozyme injections decreased mortality from challenge with Aeromonas salmonicida more than threefold and oral administration decreased mortality from infectious pancreatic necrosis virus twofold (Siwicki et al, 1998).…”

Studies on the Intestinal Absorption of Pollen Proteins, Observations on Rat.

“…These facts indicate that some proteins should be absorbed through healthy intestinal mucosa without being decomposed into oligopeptides or amino acids. Actually, as clearly demonstrated elsewhere, some basic proteins like hog pancreas elastase and egg white lysozyme are absorbed through healthy intestinal mucosa without being decomposed into nonantigenic components [9,10].…”

“…Unexpectedly, the kidney tissues showed distinct positive reaction for the PPs staining indicating that a quantity of PPs absorbed from intestine would be excreted rapidly into glomerular urine and reabsorbed by the cells of proximal convoluted tubules, just as egg white lysozyme is absorbed from intestine [9].…”

“…Actually, it has been demonstrated by Seno and associates that some basic proteins like pancreatic elastase and egg white lysozyme [9,10] and also cationic ferric colloid particles [1] are absorbed through the normal rat intestinal mucosa by ionic binding without decomposition.…”