1999
DOI: 10.1021/bi981679a
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Intestinal Absorption of Dietary Cholesteryl Ester Is Decreased but Retinyl Ester Absorption Is Normal in Carboxyl Ester Lipase Knockout Mice

Abstract: Carboxyl ester lipase (CEL; EC 3.1.1.13) hydrolyzes cholesteryl esters and retinyl esters in vitro. In vivo, pancreatic CEL is thought to liberate cholesterol and retinol from their esters prior to absorption in the intestine. CEL is also a major lipase in the breast milk of many mammals, including humans and mice, and is thought to participate in the processing of triglycerides to provide energy for growth and development while the pancreas of the neonate matures. Other suggested roles for CEL include the dir… Show more

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Cited by 124 publications
(83 citation statements)
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“…Digestive enzymes including pancreatic lipase, carboxyl esterase and phospholipase A, secreted into the intestinal lumen, continue the digestion of dietary lipids [52] . As vitamin E in the human diet is mostly not esterified, the importance of the lipolytic degradation in the digestion system is likely limited [46] , but the need for gastric hydrolysis of the stabilized after high-dose vitamin E intake for at least one year.…”
Section: Intestinal Absorptionmentioning
confidence: 99%
“…Digestive enzymes including pancreatic lipase, carboxyl esterase and phospholipase A, secreted into the intestinal lumen, continue the digestion of dietary lipids [52] . As vitamin E in the human diet is mostly not esterified, the importance of the lipolytic degradation in the digestion system is likely limited [46] , but the need for gastric hydrolysis of the stabilized after high-dose vitamin E intake for at least one year.…”
Section: Intestinal Absorptionmentioning
confidence: 99%
“…Plasma samples were obtained from the animals via tail bleeding at 0, 1, 3, 6, and 9 h after delivery of the test meal. The appearance of 3 H and 14 C in plasma was measured via scintillation counting and used to determine the rate of absorption of retinyl palmitate and TAG or cholesteryl esters, respectively.…”
Section: Celmentioning
confidence: 99%
“…Studies of CEL knockout mice show that lack of CEL appears to have no effect on the intestinal absorption of unesterified fat. 3,4 However, the cholesteryl ester hydrolytic activity is unique to CEL in the digestive tract, and CEL has been suggested to function as a supplementary enzyme to ensure effective hydrolysis of triglycerides and phospholipids. 5 The C-terminal part of CEL consists of a unique structure with proline-rich O-glycosylated repeats of 11 amino-acid residues each.…”
Section: Introductionmentioning
confidence: 99%