Intestinal absorption of colostral lymphoid cells in newborn piglets

Tuboly, S; Bernáth, Sándor; Glávits, Róbert; Medveczky, I.

doi:10.1016/0165-2427(88)90027-x

Cited by 82 publications

(57 citation statements)

References 21 publications

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“…Despite this relationship, it is still unclear whether the high uptake of immunoglobulins with the colostrum directly stimulates the development of active immunity. The colostrum also contains maternal lymphoid cells, which participate in the active immunity of the piglets (Tuboly et al, 1988), and many immune modulators, such as cytokines, which may participate in the maturation of the neonate immune system (Salmon et al, 2009). Therefore, although the mechanisms still have to be determined, it is most likely that the acquisition of good passive immunity via the consumption of colostrum stimulates the development of the piglet's active immunity.…”

Section: Discussionmentioning

confidence: 99%

Influence of colostrum intake on piglet survival and immunity

Devillers

Dividich

Prunier

2011

Animal

226

185

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Colostrum intake from birth to 24 h after the onset of parturition ( T 24 ) was estimated for 526 piglets from 40 litters. Plasma concentrations of immunoglobulin G (IgG), lactate, glucose and cortisol were determined at T 24 for six piglets per litter. Plasma IgG concentration was also assayed at weaning (28 days) on the same piglets. Rectal temperature was measured at T 24 on all piglets. Mortality was recorded until weaning and comparisons were made between piglets that died before weaning and those that were still alive at weaning. The piglets that died before weaning had lower birth weight, lower colostrum intake, lower weight gain between birth and T 24 , and had a lower rectal temperature, higher plasma cortisol concentration and lower plasma IgG and glucose concentrations at T 24 than piglets still alive at weaning. In addition, a higher proportion of piglets that died before weaning had difficulty taking their first breath after birth and were affected by splayleg. Considering all piglets, colostrum intake was positively related to rectal temperature and plasma glucose concentration and negatively related to plasma cortisol concentration at T 24 . Plasma IgG concentration at T 24 was explained by colostrum intake, IgG concentration in the ingested colostrum, birth weight and birth rank (P , 0.0001). Plasma IgG concentration at weaning was related to plasma IgG concentration at T 24 (r 5 0.54; P , 0.0001) and to colostrum intake (r 5 0.32; P , 0.0001). Finally, body weight was explained by colostrum intake, birth weight and age until 6 weeks of age (P , 0.0001). These results show that colostrum intake is the main determinant of piglet survival through provision of energy and immune protection and has potential long-term effects on piglet growth and immunity.

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Section: Discussionmentioning

confidence: 99%

Influence of colostrum intake on piglet survival and immunity

Devillers

Dividich

Prunier

2011

Animal

226

185

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“…Széky et al (1999) claim that the highest absorption of immunoglobulins from colostrum takes place in the epithelial cells of the mucous membrane of the jejunum and it reaches almost two thirds of the ileum. According to Tuboly and Nagy (2000), the x most intensive absorption of immunoglobulins occurs in the ileum from the hour 4 after colostrum intake and it reaches its peak between the hours 8 and 12 after colostrum intake. We assume that the gut closure is in progress up to 12 h after birth, because the highest values of Ig were detected between hours 3 and 6 after colostrum intake with a subsequent decrease.…”

Section: Discussionmentioning

confidence: 99%

Structural changes of mucous membrane and the presence of immunoglobulins in small intestines of neonatal pigs

et al. 2013

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The structure of the small intestine of neonatal pigs has an important effect on immunoglobulin absorption. The aim of the experiment was to observe changes in the mucous membrane and the presence of immunoglobulins in the intestines of piglets during the first hours of their postnatal lives. In total, 80 piglets of the Large White breed were divided into two groups of 40 pigs. One group (control) came from an infection-free breeding, the other (experimental) group came from a breeding with the reproduction and respiration syndrome of pigs. Samples (n = 80) of duodenum, jejunum and ileum were taken at intervals of 0, 3, 6 and 12 h after colostrum intake in order to carry out histological tests. Primary pig antibodies were detected by immunohistochemical staining. The low content of immunoglobulins IgG, IgA and IgM was detected in all segments of intestines of precolostral piglets. Difference (P < 0.05) in size of the mucous membrane was found in the duodenum at the interval of 0, 3 and 6 h (46.03%), in the jejunum at 0 and 12 h (45.98%) and in favour of the control group. Compared to the control group, more Ig (P < 0.01) antibodies were observed in the experimental group: in the duodenum IgG at 12 h (37.22 vs.

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“…It should be remembered that the intestine is open not only to macromolecules but also to cells. This hypothesis should be studied, however it should not be forgotten that direct competition cannot occur since cells are absorbed by a intracellular route (Tuboly et al, 1988).…”

Section: The Role Of the Farmer And Industrymentioning

confidence: 99%

“…They follow a selective homing mechanism which is shown by a high proportion of T lymphocytes which carry the gamma/delta cellular receptor, compared to that encountered in blood sample T lymphocytes (Bertotto et al, 1991). If the milk cells can provide local protection within the intestine, the cells found in colostrum are not limited to this function since they are absorbed (Tuboly et al, 1988;Williams, 1993). This trans-intestinal passage of colostrum cells obeys specific rules since cells from the same category but from peripheral blood or from heated colostrum migrate at a very low rate across the intestinal wall compared to normal colostrum (Tuboly et al, 1988, Williams, 1993.…”

Section: Cellsmentioning

confidence: 99%

“…If the milk cells can provide local protection within the intestine, the cells found in colostrum are not limited to this function since they are absorbed (Tuboly et al, 1988;Williams, 1993). This trans-intestinal passage of colostrum cells obeys specific rules since cells from the same category but from peripheral blood or from heated colostrum migrate at a very low rate across the intestinal wall compared to normal colostrum (Tuboly et al, 1988, Williams, 1993. The contribution of cells to cellular immunity is undeniable and, for example, in the infant a positive response to a tuberculosis test can be seen to be transmitted by suckling (Schlesinger and Covelli, 1977).…”

Section: Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Acquisition of passive immunity in domestic ungulates

Grongnet¹,

Duvaux-Ponter

1998

J. Anim. Feed Sci.

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The ungulates possess an epteriochondrial placenta, which separates the maternal and foetal blood systems and thus reduces the permeability of the placenta to small molecules. Thus, in these species, the colostral imminoglobulins are the main source of protection factors which aid survival in the first days of life. This review deals with several aspects of passive immunity in ungulate neonates: the type and the origin of colostral immunoglobulins and factors which influence their production in the mother and their absorption form the gastrointestinal tract of the neonate.Recommendations for farmes to enhance natural postnatal immunity and recent technological advances in the production of immunoglobulin preparations are discussed.

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Intestinal absorption of colostral lymphoid cells in newborn piglets

Cited by 82 publications

References 21 publications

Influence of colostrum intake on piglet survival and immunity

Influence of colostrum intake on piglet survival and immunity

Structural changes of mucous membrane and the presence of immunoglobulins in small intestines of neonatal pigs

Acquisition of passive immunity in domestic ungulates

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