Intestinal absorption and utilization of radiomethionine in old age

Pénzes, L; Simon, G; Winter, Michael

doi:10.1016/0531-5565(68)90010-7

Cited by 12 publications

(1 citation statement)

References 16 publications

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“…It should be emphasized that a decrease in absorption with age is not a consistent finding. The data on fats (39, 40) are equivocal and it has been reported that the absorption of methionine and cysteine increases with age, probably attributable to increased needs for these materials during senescence (41, 42).…”

Section: Absorptionmentioning

confidence: 99%

Pharmacodynamic Principles of Drug Therapy in the Aged*

Bender¹

1974

J American Geriatrics Society

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The geriatric patient responds differently to some drugs than does the younger adult, and consequently certain precautions should be taken when prescribing a therapeutic regimen for the elderly. Increasing age is accompanied by functional changes in many of the systems that control the way a drug is metabolized and the response that it evokes. Apparently it is these changes which underlie the modified effect seen clinically in geriatric patients. Age tends to reduce and delay the absorption of substances from the gastrointestinal tract, impair and delay drug clearance and excretion by the kidneys, and reduce the rate of enzyme destruction. The plasma half‐life of penicillin, digoxin, antipyrine, or phenylbutazone is extended significantly in the aged so that higher circulating concentrations are maintained for longer periods. Other age‐related changes influence the effect of a drug once it has combined with its receptor. These include an altered number of receptor sites, a decrease in the transmitter content of affected tissues, an increase in the rigidity of responsive tissues, and an overall decline in homeostatic capability.

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Section: Absorptionmentioning

confidence: 99%

Pharmacodynamic Principles of Drug Therapy in the Aged*

Bender¹

1974

J American Geriatrics Society

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The Gastrointestinal Tract

Holt

1995

Comprehensive Physiology

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The sections in this article are: Salivary Glands Stomach Gastric Secretion Small Intestine Morphology Brush Border Membranes Enzymes Intestinal Permeability Protein Synthesis Intestinal Absorption Gut‐Associated Immune System Splanchnic Blood Flow Gastrointestinal Motility Esophagus Stomach Neuromuscular Functioning Colon and Rectum Pancreas Liver and Biliary Tree Morphology Age‐Associated Effects Consequences of Aging Bile Gastrointestinal Hormones Cellular Proliferation Esophagus and Stomach Small Intestine Colon Effects of Caloric Restriction

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