Interweaving of reactive oxygen species and major neurological and psychiatric disorders

Umare, Mohit D; Wankhede, Nitu L.; Bajaj, Komal; Trivedi, Rashmi V.; Taksande, Brijesh G.; Umekar, Milind J.; Mahore, Jayashri G.; Kale, Mayur B.

doi:10.1016/j.pharma.2021.11.004

Cited by 14 publications

(4 citation statements)

References 162 publications

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“…High levels of ROS have been linked to cell death and degeneration, notably in disorders that include type 2 diabetes, Alzheimer’s disease, autism, mood disorders and attention-deficit/hyperactivity disorder (ADHD), among others ( Michel et al, 2012 ). These observations have been expanded in recent studies that demonstrate correlations between mitochondrial dysfunction and various psychiatric disorders ( Burtscher et al, 2022 ; Chen et al, 2022 ; Umare et al, 2022 ). In these cases, viruses and bacteria were identified as tightly involved in promoting alterations of mitochondrial and host cellular function via hypoxia and immune-mediated upregulation of inflammatory factors and conditions associated with oxidative stress.…”

Section: Introductionmentioning

confidence: 90%

Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms

et al. 2023

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Mitochondria are complex endosymbionts that evolved from primordial purple nonsulfur bacteria. The incorporation of bacteria-derived mitochondria facilitates a more efficient and effective production of energy than what could be achieved based on previous processes alone. In this case, endosymbiosis has resulted in the seamless coupling of cytochrome c oxidase and F-ATPase to maximize energy production. However, this mechanism also results in the generation of reactive oxygen species (ROS), a phenomenon that can have both positive and negative ramifications on the host. Recent studies have revealed that neuropsychiatric disorders have a pro-inflammatory component in which ROS is capable of initiating damage and cognitive malfunction. Our current understanding of cognition suggests that it is the product of a neuronal network that consumes a substantial amount of energy. Thus, alterations or perturbations of mitochondrial function may alter not only brain energy supply and metabolite generation, but also thought processes and behavior. Mitochondrial abnormalities and oxidative stress have been implicated in several well-known psychiatric disorders, including schizophrenia (SCZ) and bipolar disorder (BPD). As cognition is highly energy-dependent, we propose that the neuronal pathways underlying maladaptive cognitive processing and psychiatric symptoms are most likely dependent on mitochondrial function, and thus involve brain energy translocation and the accumulation of the byproducts of oxidative stress. We also hypothesize that neuropsychiatric symptoms (e.g., disrupted emotional processing) may represent the vestiges of an ancient masked evolutionary response that can be used by both hosts and pathogens to promote self-repair and proliferation via parasitic and/or symbiotic pathways.

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Section: Introductionmentioning

confidence: 90%

Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms

et al. 2023

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“…Neurotrophic factors and cytokines that defend neurons against Aβ-induced death undoubtedly prevent neuronal apoptosis and caspase activation . Many investigations have demonstrated lowered expression of neurotrophin brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases such as AD, Parkinson’s disease, Huntington’s disease, schizophrenia, and depression patients because of the effect of oxidative and apoptotic stress. , The inflammation and deterioration of cholinergic neurons play a crucial role in the pathogenesis of degenerative changes and cognitive disorders associated with AD . Major pro-inflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor (TNF-α), play a central role in promoting and regulating cytokine activation during an inflammatory response in AD patient serum …”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Thiazolidine-2,4-dione Derivatives on Memory Deficits and Neuropathological Symptoms of Dementia on a Scopolamine-Induced Alzheimer’s Model in Adult Male Wistar Rats

Taheri,

Ghafoori,

Sepehri

et al. 2023

ACS Chem. Neurosci.

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Alzheimer's disease (AD) is a neurodegenerative disorder associated with a decline in memory deficits and neuropathological diagnosis with loss of cholinergic neurons in the brains of older adults. Based on these facts and an increasing number of involved people worldwide, this investigation aimed to study the improvement of memory and cognitive impairments via an anticholinergic approach of thiazolidine-2,4-diones (TZDs) in the scopolamine-induced model of Alzheimer type in adult male Wistar rats (n = 40). The results indicated data analysis obtained from in vivo and in vitro tests for (E)-5-(3-hydroxybenzylidene)-3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione (TZ3O) (2 and 4 mg/kg) with the meta-hydroxy group and (E)-5-(4methoxybenzylidene)-3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione (TZ4M) (2 and 3 mg/kg) with the para-methoxy group showed a neuroprotective effect. TZ3O and TZ4M alleviated the scopolamine-induced cognitive decline of the Alzheimer model in adult male Wistar rats. These initial and noteworthy results could be assumed as a starting point for the evolution of new anti-Alzheimer agents.

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“…(Demirci-Çekiç et al, 2022). Therefore, OS can occur due to an upsurge of 'reactive oxygen species (ROS)', a decline of the antioxidant systems or both (Umare et al, 2022). Paraoxonase 1 (PON1) is a 'high-density lipoprotein (HDL)' related antioxidant enzyme with phospholipase activity (Sucato et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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2023

Pak. J. Pharm. Sci.,

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To compare the effect of vitamin D treatment on total antioxidant capacity (TAOC), paraoxonase 1 (PON1) and anti-müllerian hormone (AMH) in infertile females with and without polycystic ovary syndrome (PCOS) were studied. It was a case-control study involving a total of 180 participants; 114 (63 %) PCOS and 66 (37 %) non-PCOS infertile female subjects from 2020-2022. Study participants received a single injection of vitamin D cholecalciferol (300,000 IU) once in the study period. Serum levels of vitamin D, AMH, TAOC and PON1 were determined before and after treatment. The quantitative variables were calculated by means and standard error of the mean (SE), compared by paired t test; significance at p<0.05. The mean age was comparable in both groups whereas the body mass index (BMI) of PCOS females was higher (p<0.001). Vitamin D and AMH were significantly low in PCOS vs. non-PCOS females (p<0.001). TAOC and PON1 mean levels in both groups were comparable. The biomarker levels improved in both groups after vitamin D treatment more in PCOS females (p<0.001). Vitamin D elicited improvement of oxidative stress in infertile females with and without PCOS, however, the dominant and significant role in PCOS is the one highlighted in our study.

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Interweaving of reactive oxygen species and major neurological and psychiatric disorders

Cited by 14 publications

References 162 publications

Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms

Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms

Neuroprotective Effect of Thiazolidine-2,4-dione Derivatives on Memory Deficits and Neuropathological Symptoms of Dementia on a Scopolamine-Induced Alzheimer’s Model in Adult Male Wistar Rats

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