Intervertebral disc calcification in thalassemia intermedia

Aessopos, Athanasios; Tsironi, Maria; Polonifi, Katerina; Baltopoulos, Panagiotis; Vaiopoulos, George

doi:10.1111/j.1600-0609.2007.00987.x

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…Guo et al concluded that serum iron was negatively correlated with the degree of IVDD by a clinical study [ 59 ]. Nevertheless, Aessopos et al suggested that the serum ferritin concentration was not responsible for intervertebral disc calcification in patients with thalassemia intermedia [ 60 ]. Notably, cellular iron homeostasis is important for the normal physiological functions of the body, and both iron overload and deficiency can have disastrous consequences for intervertebral disc cells.…”

Section: Potential Mechanisms Of Ferroptosis In Ivddmentioning

confidence: 99%

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy

Chen

Yang

Feng

et al. 2022

Cells

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Intervertebral disc degeneration (IVDD) is a common pathological condition responsible for lower back pain, which can significantly increase economic and social burdens. Although considerable efforts have been made to identify potential mechanisms of disc degeneration, the treatment of IVDD is not satisfactory. Ferroptosis, a recently reported form of regulated cell death (RCD), is characterized by iron-dependent lipid peroxidation and has been demonstrated to be responsible for a variety of degenerative diseases. Accumulating evidence suggests that ferroptosis is implicated in IVDD by decreasing viability and increasing extracellular matrix degradation of nucleus pulposus cells, annulus fibrosus cells, or endplate chondrocytes. In this review, we summarize the literature regarding ferroptosis of intervertebral disc cells and discuss its molecular pathways and biomarkers for treating IVDD. Importantly, ferroptosis is verified as a promising therapeutic target for IVDD.

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Section: Potential Mechanisms Of Ferroptosis In Ivddmentioning

confidence: 99%

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy

Chen

Yang

Feng

et al. 2022

Cells

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“…In comparison to age-and sex-matched controls, βTM patients also show statistically significant more severe and extensive degenerative disc disease with no clear mechanism suggested by the literature so far 48 . Its pattern is different exhibiting a multilevel involvement -the whole lumbar spine and several thoracic levels are affected-, intranuclear gas and calcification within discs ( Figure 6) 42,49 .…”

Section: Spinementioning

confidence: 99%

Skeletal radiological findings in thalassemia major

Adamopoulos¹,

Petrocheilou²

2020

JRPMS

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Skeletal changes in beta-thalassemia major (βTM) create a wide spectrum of bone radiographic features. The main pathology is extensive marrow proliferation due to ineffective erythropoiesis but the relative skeletal findings are encountered with a progressively reduced frequency and severity nowadays due to the regular hypertransfusion programs. The resulting hemosiderosis and particularly iron chelation therapy have been associated with dysplastic features which are found more often. Skeletal radiological appearances in βTM relate to a complex multifactorial pathogenesis (i.e. marrow expansion, direct iron and chelation toxicity, endocrine complications) and depend on the severity and duration of the disease, the type and effectiveness of treatment and the toxic effects of chelation therapy. Awareness of these findings is very important since early recognition can be an indicator for therapy adaptation.

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“…They suggested the possibility of early iron chelation therapy in order to prevent complications from IDC. Incidence of IDC in the general adult population is approximately 5–6% and approaches 45% in those over the age of 85 years 6. Presence of IDC in this patient was likely secondary to her underlying condition and not to iron chelation therapy, as treatment was initiated after imaging documentation of two levels of IDC.…”

Section: Discussionmentioning

confidence: 81%

“…Aessopos et al 6 reported intervertebral disc calcification (IDC) in 7 of 30 (23.33%) β-thalassaemia intermedia patients. The patients with IDC had more back pain but otherwise had similar laboratory parameters (of iron excess, extramedullary haematopoiesis, etc) compared to those without IDC.…”

Section: Discussionmentioning

confidence: 99%

Disappearing large calcified thoracic disc herniation in a patient with thalassaemia

et al. 2016

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SUMMARYRegression of herniated disc fragments with subsequent improvement in clinical symptoms has been reported in the lumbar and cervical spine. Such regressions in the thoracic spine are extremely rare. We report a case of a 38-year-old patient with thalassaemia who had regression of a large calcified herniated thoracic disc causing cord compression, with subsequent herniation of a second calcified disc at a different level and discuss the possible aetiopathogenesis. This is the first such case reported in the thalassaemia population. BACKGROUND

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Intervertebral disc calcification in thalassemia intermedia

Cited by 6 publications

References 15 publications

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy

Skeletal radiological findings in thalassemia major

Disappearing large calcified thoracic disc herniation in a patient with thalassaemia

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