442 pre-ART, HIV-infected adults were randomized to peer support consisting of structured home visits to promote clinic attendance and preventive care intervention use or standard of care. At baseline, 62% reported previously visiting an HIV clinic, 45% reported taking cotrimoxazole prophylaxis, and 31% were “care-naïve” (no previous clinic visit and not on cotrimoxazole). After one year, intervention participants were more likely to report being in care (92% vs 84%; PRR 1.09, p=0.039), on cotrimoxazole (89% vs 81%; PRR 1.10, p=0.047), and safe water vessel adherence (23% vs 14%; PRR 1.64, p=0.024). The effect was observed only among care-naïve participants (n=139) with 83% intervention vs 53% controls reporting being in HIV care (PRR 1.47, p=0.006), 78% vs 58% on cotrimoxazole (PRR 1.35, p=0.04), and 20% vs 4% safe water vessel adherence (PRR 5.78, p=0.017). Peer support may be an effective intervention to facilitate pre-ART care compliance in this important population.