Interventions to improve adherence to antiretroviral therapy in children with HIV infection

Bain-Brickley, Deborah; Butler, Lisa; Kennedy, Gail; Rutherford, George W.

doi:10.1002/14651858.cd009513

Cited by 73 publications

(68 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other reviews on interventions to improve adherence to ART have identified similar limitations, including the paucity of research on adherence enhancing interventions in younger populations, 22 the need for behavioral theories that are relevant to Africa, the lack of data on cost-effectiveness, 86 and methodological limitations. 87 More complex interventions are not necessarily better than simple ones.…”

Section: Agreements or Disagreements With Other Reviewsmentioning

confidence: 99%

“…87 One also reported finding studies that improved clinical outcomes without improvements in adherence, suggesting an alternate mechanism for health outcomes in children. 22 Two context specific systematic reviews report that reminders may have beneficial effects on adherence in sub-Saharan Africa, though these effects are small. 88,89 A third noted poor methodological quality and few effective interventions in developed countries.…”

Section: Agreements or Disagreements With Other Reviewsmentioning

confidence: 99%

“…21 Given the above, it is critical from a public and individual perspective to investigate and describe the interventions that are effective in improving adherence to ART. Systematic reviews report that there is limited evidence on interventions to improve adherence to ART in the pediatric population; 22 yet older adults are less likely to be non-adherent; 23 there may be benefit in addressing mental health issues that affect adherence; 5,24,25 motivational interviewing may offer some benefit, 26 and reduce viral load in youth. 27 Weekly reminder text messages [28][29][30] and treatment supporters 29 also improve adherence and reduce viral load in low resource settings.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies

Mbuagbaw

Sivaramalingam

Navarro

et al. 2015

AIDS Patient Care and STDs

View full text Add to dashboard Cite

We sought to review the effectiveness of interventions designed to improve adherence to antiretroviral therapy (ART) from studies included in a recent Cochrane review that reported a clinical and an adherence outcome, with at least 80% follow-up for 6 months or more. Data were extracted independently and in duplicate, with an adjudicator for disagreements. Risk of bias was assessed using the Cochrane Risk of Bias tool. Of 182 relevant studies in the Cochrane review, 49 were related to ART. Statistical pooling was not warranted due to heterogeneity in interventions, participants, treatments, adherence measures and outcomes. Many studies had high risk of bias in elements of design and outcome ascertainment. Only 10 studies improved both adherence and clinical outcomes. These used the following interventions: adherence counselling (two studies); a once-daily regimen (compared to twice daily); text messaging; web-based cognitive behavioral intervention; face-to-face multi-session intensive behavioral interventions (two studies); contingency management; modified directly observed therapy; and nurse-delivered home visits combined with telephone calls. Patient-related adherence interventions were the most frequently tested. Uniform adherence measures and higher quality studies of younger populations are encouraged.

show abstract

Section: Agreements or Disagreements With Other Reviewsmentioning

confidence: 99%

Section: Agreements or Disagreements With Other Reviewsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies

Mbuagbaw

Sivaramalingam

Navarro

et al. 2015

AIDS Patient Care and STDs

View full text Add to dashboard Cite

show abstract

“…In young children, the correct use of medicines poses specific challenges to parents, caregivers and health care professionals that are usually not encountered in adults (Matsui, 2007;Breitkreutz and Boos, 2007;Polaha et al, 2008;Bain-Brickley et al, 2011;Terry and Sinclair, 2012). For example, the medicine may not be commercially available in the required strength (a 2 mg tablet needs breaking or splitting to administer a 1 mg dose), the medicine may not be available in a dosage form that the child is able to take (babies cannot swallow large tablets), or the medicine may not be available in a dosage form that the child is willing to take (bad taste; adequate taste, but child does not like it; recalcitrance) (Balakrishnan et al, 2007;Balakrishnan et al, 2006;van Riet-Nales et al, 2011;Walsh et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Methods of administering oral formulations and child acceptability

Riet‐Nales

Ferreira

Schobben

et al. 2015

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…219,226,227,269,[276][277][278][279] The literature review and systematic review of validated adherence scales will allow the selection of adherence scales that will be able to identify non-adherent patients with chronic cardiovascular disease and explore the patient-specific reasons for non-adherence.…”

Section: Discussionmentioning

confidence: 99%

Improving medication adherence in patients with chronic disease using a targeted and tailored approach

Nguyen¹

View full text Add to dashboard Cite

Improving adherence to medications is an opportunity that can yield great improvements in health outcomes and reducing health costs. Supporting adherence to medicines requires insight into a patient's medication-taking behaviour and their reasons for non-adherence.Adherence interventions that show most promise include multifaceted interventions, and those targeted to non-adherent patients and/or tailored to patient-specific reasons for nonadherence. To identify non-adherent patients and their reasons for non-adherence in the practice setting, I argue that we require inexpensive measures that are easy to use and can inform the discussion with patients about their adherence. Adherence scales are inexpensive, easy-to-administer and have the potential to explore both medication-taking behaviour and reasons for behaviour.The overall aim of the thesis is to determine if a targeted and tailored intervention based on a discussion informed by validated adherence scales, will improve adherence to a recently initiated cardiovascular medication. I hypothesise that targeting and tailoring an intervention to non-adherent participants based on a discussion informed by adherence scales, will improve adherence at three months as measured by the four-item Medication Adherence Questionnaire (MAQ). I will also test whether improvements in adherence at three months are sustained at six months and explore the changes in adherence and reasons for nonadherence over time.The first part of the thesis involved identifying validated adherence scales suitable for use in the intervention. A systematic review was conducted on adherence scales to explore their use and validation. We found that adherence scales measured different aspects of adherence: medication-taking behaviour, barriers to adherence and beliefs associated with adherence. Adherence scales have been validated in different disease populations and against different measures of adherence. We selected two adherence scales for our study: the MAQ and Beliefs about Medicines Questionnaire-Specific (BMQ-S). The MAQ is one of the most commonly used adherence scales that has been validated in many disease populations and against different measures of adherence including electronic monitoring.The BMQ-S has been extensively used to elicit medication beliefs associated with medication adherence and validated in a number of diseases including cardiovascular disease, asthma and depression.A randomised controlled trial was conducted to determine if a targeted and tailored intervention would improve medication adherence. Four hundred and eight patients were iii assessed for eligibility from two community pharmacies, from which 152 patients were enrolled into the study. All enrolled participants completed the MAQ, BMQ-S and Brief Illness Perceptions Questionnaire (BIPQ). There were 120 participants identified as non-adherent using the MAQ, who were randomised into an intervention or control group. The remaining 32 participants were identified as adherent. In the intervention group, the r...

show abstract

Interventions to improve adherence to antiretroviral therapy in children with HIV infection

Abstract: Interventions to improve adherence to antiretroviral therapy in children with HIV infection.

Cited by 73 publications

References 52 publications

Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies

Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies

Methods of administering oral formulations and child acceptability

Improving medication adherence in patients with chronic disease using a targeted and tailored approach

Contact Info

Product

Resources

About