Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery. a meta-analysis

Efficacy of low-dose landiolol, an ultrashort-acting β-blocker, on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer

“…Although β-blockers have been reported to be successful for preventing postoperative AF after cardiac surgery, 10 their use for heart rate control has been avoided in lung resection surgery because currently available β-blockers have a relatively longer half-life and lower cardioselectivity and might cause adverse respiratory effects. Digitalis and verapamil were widely used to control the heart rate for AF until recently in Japan.…”

Effect of low-dose landiolol, an ultrashort-acting β-blocker, on postoperative atrial fibrillation after CABG surgery

“…17 β-Blockers and amiodarone have been found to be successful strategies for preventing postoperative atrial fi brillation. 18 Among various classes of drugs, β-blockers (e.g., esmolol, 19-28 labetalol, 29,30 landiolol 31 ) are widely used to prevent detrimental events associated with tracheal intubation. Landiolol, a newly developed, commercially available agent, is an ultrashort-acting β-adrenoceptor antagonist with a half-life of 3 min; it is eight times more cardioselective than esmolol.…”

The pharmacological response of ischemia-related atrial fibrillation in dogs: Evidence for substrate-specific efficacy

“…There is, however, evidence for efficacy of β-blockers (class 2 antiarrhythmic-drugs) [3,4] and diltiazem (a class 4 agent) [5,6] for sinus-rhythm maintenance post-cardiothoracic surgery. Sustained-release metoprolol has weak but statisticallysignificant sinus-rhythm maintenance properties post-AF cardioversion [7].…”