Interventions for treating people with symptoms of bladder pain syndrome: a network meta-analysis

Imamura, Mari; Scott, Norman; Wallace, S; Ogah, Joseph; Ford, Abigail; Dubos, Yann A; Brazzelli, Miriam

doi:10.1002/14651858.cd013325.pub2

Cited by 13 publications

(20 citation statements)

References 127 publications

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“…The multifaceted effects of this disease demand a holistic treatment approach, based on a biopsychosocial model, which reflects the non-specific phenotypes. A plethora of therapies exist in current clinical practice and these range from conservative approaches to reconstructive surgery [6,7]. Among this treatment catalogue, exists intravesical therapies, which typically represent the next step in the treatment algorithm when conservative measures and pharmacotherapy have failed.…”

Section: Manuscriptmentioning

confidence: 99%

Current Status of Intravesical Therapies for Bladder Pain Syndrome (BPS): A Narrative Review of Emerging Evidence

Jones

Hjelle

Mohn

et al. 2021

Urology

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Section: Manuscriptmentioning

confidence: 99%

Current Status of Intravesical Therapies for Bladder Pain Syndrome (BPS): A Narrative Review of Emerging Evidence

Jones

Hjelle

Mohn

et al. 2021

Urology

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“…Thus, the use of both terms in parallel is allowed to denote this disease. 2 Even though IC has been known and recognized for a long time, the causes and etiology are poorly understood at the moment. In this regard, approaches to the diagnosis and treatment of BPS/IC are controversial.…”

Section: Introductionmentioning

confidence: 99%

Pentosan polysulfate in patients with bladder pain syndrome/interstitial cystitis with Hunner’s lesions or glomerulations: systematic review and meta-analysis

Grigoryan

Kasyan

Pivazyan

et al. 2022

Therapeutic Advances in Urology

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Background: Bladder pain syndrome/interstitial cystitis (BPS/IC) is a persistent pain perceived in the urinary bladder region, accompanied by at least one symptom, such as pain worsening with bladder filling and daytime or nighttime urinary frequency without any proven infection or obvious pathology. The aim of this study is to evaluate the efficacy and safety of pentosan polysulfate (PPS) in patients with BPS/IC. Methods: Systematic search was performed by PRISMA checklist. Electronic databases, including PubMed and Cochrane library, were checked until 2021 using keywords: ‘pentosan polysulfate’, ‘pain syndrome’, ‘interstitial cystitis’, and bibliography of relevant papers was checked. Inclusion criteria: Patients with confirmed diagnosis of BPS/IC and cystoscopy criteria – Hunner’s lesions. Exclusion criteria included hypersensitivity, pregnancy, lactation, and oral therapy for BPS/IC in the period of 1 month before the study and abstracts or unpublished papers. Results: In total, 13 clinical trials were included in systematic review and 7 were included in meta-analysis. Studies evaluated the effectiveness and safety of oral PPS versus placebo or other treatment options. In the first meta-analysis, three studies compared oral PPS with placebo: [relative risk (RR) = 2.07, 95% confidence interval (CI): 1.37–3.13, p = 0.0006]. The second meta-analysis of two studies compared oral PPS with another treatment options (intravesical liposome and CyA): (RR = 0.44, 95% CI: 0.10–1.93, p = 0.28). The third meta-analysis of two studies included intravesical regimen of PPS compared with intravesical placebo: (RR = 1.09, 95% CI: 0.54–2.22, p = 0.80). The majority of studies do not report any particular serious side effects. Conclusion: PPS treatment has a statistically significant effect over placebo on the subjective improvement of patients with BPS/IC. There was no difference between PPS and other treatment options. Intravesical regimen of PPS had no significant impact on response rates. None of included studies reported severe side effects after intervention.

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“…According to a Cochrane review, there is insufficient evidence to endorse any of the 65 different treatments for BPS, which involve medication, behavioral therapy and physiotherapy. 159 Nevertheless, despite the fact that the proposed treatments for this condition are far from ideal, measures involving neuroeducation and dietary measures are considered first-line. 160 Amitriptyline, which is widely used and inexpensive, is a second-line option, with some analgesic, anticholinergic, sedative, anxiolytic and antidepressant effects, which could improve urinary frequency if the patient is able to tolerate at least 50 mg/day.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

Current Challenges in the Management of Chronic Pelvic Pain in Women: From Bench to Bedside

Siqueira-Campos¹,

Deus²,

Neto³

et al. 2022

IJWH

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Chronic pelvic pain (CPP) affects a significant proportion of women worldwide And has a negative impact on several aspects of these women’s lives including mental health, work, relationships and sexual function, among others. This set of factors ultimately reflects negatively on quality Of life. The physiopathology of CPP is complex and remains to be fully clarified; however, recent advances have increased understanding of the mechanisms involved in chronic pain in general, and more specifically, CPP. Nonetheless, even when a detailed clinical history is obtained, meticulous physical examination is performed and imaging resources are appropriately used, the organic cause of the pain may still fail to be identified in a substantial number of women with CPP. Management of CPP may therefore be challenging. This narrative review was aimed at adding to the available literature on the subject, presenting and discussing the principal characteristics of CPP in women. The paper highlights gaps in the literature while providing the most up-to-date evidence associated with the physiopathology and classification of pain, its diagnosis and treatment. In addition, current challenges in the management of women with CPP are discussed.

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Interventions for treating people with symptoms of bladder pain syndrome: a network meta-analysis

Abstract: Interventions for treating people with symptoms of bladder pain syndrome: a network meta-analysis.

Cited by 13 publications

References 127 publications

Current Status of Intravesical Therapies for Bladder Pain Syndrome (BPS): A Narrative Review of Emerging Evidence

Current Status of Intravesical Therapies for Bladder Pain Syndrome (BPS): A Narrative Review of Emerging Evidence

Pentosan polysulfate in patients with bladder pain syndrome/interstitial cystitis with Hunner’s lesions or glomerulations: systematic review and meta-analysis

Current Challenges in the Management of Chronic Pelvic Pain in Women: From Bench to Bedside

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