Interventions for treating oral lichen planus

Chan, Edwin Sy; Thornhill, Martin H.; Zakrzewska, Joanna Jm

doi:10.1002/14651858.cd001168

Cited by 48 publications

(55 citation statements)

References 20 publications

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“…The disease can be generalised where systemic therapies were given in order to treat the disease. [2,3,4,5,6,7,8,9,10] Out of all systemic modalities oral corticosteroids, [3,11,12,13] are the mainstay of therapy, in present study an attempt was made to compare the efficacy between oral mini pulse therapy with betamethasone, [12] and oral acitretin. [5] Age Distribution: In present study, Out of 60 patients, 78.33% of lichen planus cases were in age group of 30-60years which is comparable to western study by melgren et al Sex distribution ( Table 9): In present study female patients outnumbered males in a ratio of 2.1:1, which is nearly comparable to study by vijay kumar et al, In a study done by ramesh et al, [13] male patients outnumbered females, (54.28%) patients were males and 16(45.71%) were females.…”

Section: Resultsmentioning

confidence: 99%

“…The present study was done to compare the efficacy between oral betamethasone mini pulse therapy and oral acitretin and to know the relapse rate. [2,3,4,5,6,7,8,9,10] MATERIALS AND METHODS: The study was carried out on patients who were clinically diagnosed as generalised lichen planus, attending the outpatient department of dermatology, venereology and leprosy, King George hospital, affiliated to Andhra medical college, Visakhapatnam from November 2011 to December 2012. A total of 60 patients were included in study and divided into two equal groups.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Study of Comparative Effeiciency of Oral Mini Pulse Therapy Versus Oral Acitret in in Genaralised Lichen Planus

P¹,

S²,

Shalini³

et al. 2015

jemds

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BACKGROUND:Lichen planus is a chronic inflammatory disease that effects skin, mucous membranes, hair and nails. There are several drugs both topical and systemic for the treatment of lichen planus. AIMS AND OBJECTIVES: Present study was done to compare the efficacy between oral mini pulse therapy with betamethasone and with acetretin in the management of generalised lichen planus. MATERIALS AND METHODS: The study was carried out on patients who were clinically diagnosed as generalised lichen planus, attending the outpatient department of dermatology, venereology and leprosy, King George hospital, affiliated to Andhra medical college, Vishakhapatnam from November 2011 to December 2012. A total of 60 patients were included in study and divided into two equal groups. Group1 patients were treated with 0.1mg/kg of oral betamethasone given on 2 consecutive days in a week till 8 weeks and tapered. Group 2 patients were treated with 0.5mg/kg of acetretin for 8 weeks and tapered. INCLUSION CRITERIA: All patients of age group in between 11-60 years, of either sex, suffering from lichen planus of duration >3 months, and women in group 2 who were in reproductive age group on two methods of contraception were included. EXCLUSION CRITERIA: Pregnant and lactating women, in Group 1: patients suffering from diabetes, hypertension, peptic ulcer disease, renal, hepatic, heart disease or tuberculosis, in Group 2: patients with abnormal lipid profile, diabetes, hypertension, renal, liver or heart disease were excluded. RESULTS: out of 60 patients enrolled in study, 2 patients from group 1 and 5 patients from group 2 were dropped from study and results were concluded. Majority of patients were in age group of 31-60 (78.3%) with male to female ratio of 2.1:1.Group 1 patients at the end of 8 weeks response was seen in 92.8%, with relapse rate of 15.38% after 6 months of follow up. Group 2 patients at end of 8 weeks response was seen in 72 % with relapse rate of 5.5%. CONCLUSION: In our study oral mini pulse therapy with betamethasone has early onset of action and with a complete response in majority of patients with slightly more relapse rate when compared to oral acetretin. Oral acetretin has less relapse rate due to prolonged half-life.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Study of Comparative Effeiciency of Oral Mini Pulse Therapy Versus Oral Acitret in in Genaralised Lichen Planus

P¹,

S²,

Shalini³

et al. 2015

jemds

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“…A recent systematic review by the Cochrane group 30 of all published reports of randomized placebo-controlled trials of palliative treatment for patients with symptomatic OLP concluded that there was only weak evidence that the evaluated treatment were superior to placebo. Specifically, 9 qualifying studies examining the effect of topical steroids, topical cyclosporine, and topical and systemic retinoids were analyzed.…”

Section: Phenytoinmentioning

confidence: 99%

Treatment modalities of oral lichen planus

Patil¹,

Khandelwal²,

Sinha³

et al. 2016

J Oral Diag

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AbstrAct:Oral lichen planus is an immunologically based, chronic, inflammatory, mucocutaneous disorder of undetermined etiology. It is a relatively common disorder affecting stratified squamous epithelia. It is of special importance due to its malignant potential and can be a source of morbidity. The management of oral lichen planus should therefore address both the transformation rate as well as the patient symptoms. Care and management of such patients challenges even the most experienced clinician. There is currently no cure for OLP. Treatment is aimed primarily at reducing the length and severity of symptomatic outbreaks. The review critically analyses the various options in the literature and discusses the practical management from the Indian perspective.

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“…23 Efalizumab is a recombinant humanized monoclonal IgG1 antibody that binds to CD11a, the ␣ subunit of LFA-1 (lymphocyte function-associated antigen 1). It is currently Food and Drug Administration-approved for the treatment of plaque psoriasis.…”

Section: Commentmentioning

confidence: 99%