Interventions for the management of fatigue in adults with a primary brain tumour

Day, Julia; Yust‐Katz, Shlomit; Cachia, David; Wefel, Jeffrey S.; Lukats, Ivo W Tremont; Bulbeck, Helen; Rooney, Alasdair G

doi:10.1002/14651858.cd011376.pub3

Cited by 4 publications

(8 citation statements)

References 67 publications

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“…Scoping reviews serve as an invaluable tool when delving into emerging research areas 30. Unlike systematic or Cochrane reviews, which often focus on specific research designs like RCTs, scoping reviews cover a broader range of methods, ensuring a more comprehensive overview of the topic 17 31. This is beneficial when navigating evolving fields, such as non-pharmacological interventions for CRF in PBT patients.…”

Section: Methodsmentioning

confidence: 99%

“…All three studies reported no significant effect of the pharmacological intervention on CRF compared with the control arm 18–20. Currently, there are limited options for managing CRF in patients with a PBT 17. Non-pharmacological evidence to date has predominantly focused on movement interventions, physical activity and exercise.…”

Section: Introductionmentioning

confidence: 95%

“…A Cochrane review (updated 2022) of ‘Interventions for the management of CRF in adults with a primary brain tumour’ explored efficacy of interventions. This review included three randomised control trials (RCT) that investigated pharmacological interventions for CRF 17. All three medicines studied, modafinil, dexamfetamine sulphate and amodofinil are psychostimulants; based on the theory that promoting wakefulness could reduce CRF in patients with PBT.…”

Section: Introductionmentioning

confidence: 99%

“…This review included three randomised control trials (RCT) that investigated pharmacological interventions for CRF. 17 All three medicines studied, modafinil, dexamfetamine sulphate and amodofinil are psychostimulants; based on the theory that promoting wakefulness could reduce CRF in patients with PBT. All three studies reported no significant effect of the pharmacological intervention on CRF compared with the control arm.…”

Section: Introductionmentioning

confidence: 99%

“…Overall findings indicated that there was insufficient evidence to support the effectiveness and safety of non-pharmacological treatments for CRF in patients with PBT. 17 In contrast, while pharmacological interventions have shown limited benefits in addressing CRF and patients often express hesitation in adding more medications to their regimen, emerging evidence beyond the scope of the Cochrane review suggests some benefits of non-pharmacological interventions in the management of CRF.…”

Section: Introductionmentioning

confidence: 99%

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Non-pharmacological fatigue interventions for patients with a primary brain tumour: a scoping review protocol

Simms-Moore,

Dures,

Barua

et al. 2023

BMJ Open

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IntroductionFatigue is the most prevalent symptom for patients with a primary brain tumour (PBT), significantly reducing quality of life and limiting daily activities. Currently, there are limited options for managing cancer-related fatigue (CRF) in patients with a PBT, using non-pharmacological methods. The objective of this scoping review is to identify current and emerging evidence in relation to non-pharmacological CRF interventions for patients with a PBT.Methods and analysisElectronic databases OVID and EBSCO platforms: MEDLINE, EMBASE and CINAHL will be searched. In addition, PROSPERO, The Cochrane Library and ISI Web of Science will be searched. Trials registries CENTRAL and the International Clinical Trials Registry platform will also be searched for ongoing research. Inclusion criteria: studies from 2006 onwards, primary research on non-pharmacological interventions in patients with a PBT (>18 years). A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram will be utilised to summarise the screening process and results.Quantitative data will be analysed descriptively, while content analysis will be used for qualitative data.Findings will map the existing and emerging evidence on non-pharmacological interventions for CRF in patients with PBTs. This will provide insights into the extent and nature of the evidence in this evolving field, identifying gaps in knowledge and research priorities, and guide further investigations in this area.Ethics and disseminationEthical approval is not required for this scoping review. Findings will be disseminated via relevant peer-reviewed journals, PhD thesis, conference presentations, and shared with relevant charities and health professionals.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Non-pharmacological fatigue interventions for patients with a primary brain tumour: a scoping review protocol

Simms-Moore,

Dures,

Barua

et al. 2023

BMJ Open

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Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life

et al. 2023

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Purpose To comprehend the complex relationship between symptoms and health-related quality of life (HRQoL) in patients with diffuse glioma, we applied symptom network analysis to identify patterns of associations between depression, cognition, brain tumor-related symptoms, and HRQoL. Additionally, we aimed to compare global strength between symptom networks to understand if symptoms are more tightly connected in different subgroups of patients. Methods We included 256 patients and stratified the sample based on disease status (preoperative vs. postoperative), tumor grade (grade II vs. III/IV), and fatigue status (non-fatigued vs. fatigued). For each subgroup of patients, we constructed a symptom network. In these six networks, each node represented a validated subscale of a questionnaire and an edge represented a partial correlation between two nodes. We statistically compared global strength between networks. Results Across the six networks, nodes were highly correlated: fatigue severity, depression, and social functioning in particular. We found no differences in GS between the networks based on disease characteristics. However, global strength was lower in the non-fatigued network compared to the fatigued network (5.51 vs. 7.49, p < 0.001). Conclusions Symptoms and HRQoL are highly interrelated in patients with glioma. Interestingly, nodes in the network of fatigued patients were more tightly connected compared to non-fatigued patients. Implications for Cancer Survivors We introduce symptom networks as a method to understand the multidimensionality of symptoms in glioma. We find a clear association between multiple symptoms and HRQoL, which underlines the need for integrative symptom management targeting fatigue in particular.

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Lifestyle coaching is feasible in fatigued brain tumor patients: A phase I/feasibility, multi-center, mixed-methods randomized controlled trial

Rooney

Hewins

Walker

et al. 2022

Neuro-Oncology Practice

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BACKGROUND There are no effective treatments for brain tumor-related fatigue. We studied the feasibility of two novel lifestyle coaching interventions in fatigued brain tumor patients. METHODS This Phase I / feasibility multi-center RCT recruited patients with a clinically stable primary brain tumor and significant fatigue (mean Brief Fatigue Inventory [BFI] score ≥ 4/10). Participants were randomized in a 1-1-1 allocation ratio to: Control (usual care); Health Coaching (“HC”, an eight-week program targeting lifestyle behaviors); or HC plus Activation Coaching (“HC+AC”, further targeting self-efficacy). The primary outcome was feasibility of recruitment and retention. Secondary outcomes were intervention acceptability, which was evaluated via qualitative interview, and safety. Exploratory quantitative outcomes were measured at baseline (T0), post-interventions (T1, 10 weeks), and endpoint (T2, 16 weeks). RESULTS N=46 fatigued brain tumor patients (T0 BFI mean=6.8/10) were recruited and 34 were retained to endpoint, establishing feasibility. Engagement with interventions was sustained over time. Qualitative interviews (n=21) suggested that coaching interventions were broadly acceptable, although mediated by participant outlook and prior lifestyle. Coaching led to significant improvements in fatigue (improvement in BFI versus control at T1: HC=2.2 points [95%CI 0.6,3.8], HC+AC=1.8 [0.1,3.4], Cohen’s d [HC]=1.9; improvement in FACIT-Fatigue: HC=4.8 points [-3.7,13.3]; HC+AC=12 [3.5,20.5], d [HC&AC]=0.9). Coaching also improved depressive and mental health outcomes. Modelling suggested a potential limiting effect of higher baseline depressive symptoms. CONCLUSIONS Lifestyle coaching interventions are feasible to deliver to fatigued brain tumor patients. They were manageable, acceptable, and safe, with preliminary evidence of benefit on fatigue and mental health outcomes. Larger trials of efficacy are justified.

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Interventions for the management of fatigue in adults with a primary brain tumour

Cited by 4 publications

References 67 publications

Non-pharmacological fatigue interventions for patients with a primary brain tumour: a scoping review protocol

Non-pharmacological fatigue interventions for patients with a primary brain tumour: a scoping review protocol

Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life

Lifestyle coaching is feasible in fatigued brain tumor patients: A phase I/feasibility, multi-center, mixed-methods randomized controlled trial

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