2019
DOI: 10.1111/bjd.17590
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Interventions for rosacea based on the phenotype approach: an updated systematic review includingGRADEassessments

Abstract: SummaryBackgroundRosacea is a common chronic facial dermatosis. Classification of rosacea has evolved from subtyping to phenotyping.ObjectivesTo update our systematic review on interventions for rosacea.MethodsWe searched CENTRAL, MEDLINE, Embase, LILACS, Science Citation Index and ongoing trials registers (March 2018) for randomized controlled trials. Study selection, data extraction, risk‐of‐bias assessment and analyses were carried out independently by two authors. Grading of Recommendations, Assessment, De… Show more

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Cited by 84 publications
(155 citation statements)
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References 102 publications
(244 reference statements)
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“…This study confirmed the well-known efficacy of topical ivermectin to reduce inflammatory lesions in rosacea (36). To the best of our knowledge, this is the first study combining a broad spectrum of RCM and clinical variables to monitor rosacea during treatment.…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…This study confirmed the well-known efficacy of topical ivermectin to reduce inflammatory lesions in rosacea (36). To the best of our knowledge, this is the first study combining a broad spectrum of RCM and clinical variables to monitor rosacea during treatment.…”
Section: Discussionsupporting
confidence: 83%
“…It is hypothesized that clinical effects of rosacea treatment can be quantified and ideally also be predicted using RCM monitoring. Topical ivermectin, an antiparasitic preparation that has dual anti-inflammatory and acaricidal effects, has been widely studied as a safe, easy to use, and effective treatment to reduce papules and pustules in rosacea (36). This makes ivermectin a suitable intervention to monitor rosacea treatment effects.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, the classification system was changed from subtype-based to phenotype-based to increase diagnostic and presentation accuracy, but as many trials predate the updated phenotype approach, the subtype-based system still dominates rosacea literature. 8,[10][11][12] To achieve optimal results, rosacea treatment is preferably adjusted to clinical symptoms and disease severity. 3,13,14 However, the variety of clinical manifestations among individual patients and presence of various classification systems make standardization and quantification of rosacea measurements challenging.…”
Section: What Does This Study Add?mentioning
confidence: 99%
“…Initially, four rosacea subtypes were described: erythematotelangiectatic, papulopustular, phymatous and ocular. Recently, the classification system was changed from subtype‐based to phenotype‐based to increase diagnostic and presentation accuracy, but as many trials predate the updated phenotype approach, the subtype‐based system still dominates rosacea literature . To achieve optimal results, rosacea treatment is preferably adjusted to clinical symptoms and disease severity .…”
mentioning
confidence: 99%
“…In this issue of the BJD , van Zuuren and colleagues have published the update of their systematic review of efficacy and tolerance of interventions for rosacea, a prevalent facial dermatosis that has a significant impact on quality of life . The number of included randomized controlled trials (RCTs) has increased from 22 in the first version in 2003 to 152 in this current update, illustrating the dynamism of contemporary therapeutic research.…”
mentioning
confidence: 99%