Interventions for Old World cutaneous leishmaniasis

Heras-Mosteiro, Julio; Monge‐Maíllo, Begoña; Pinart, Mariona; Pereira, Patricia López; García-Carrasco, Emely; Cuadrado, Pedro Campuzano; Royuela, Ana; Roman, Irene Mendez; López‐Vélez, Rogelio

doi:10.1002/14651858.cd005067.pub4

Cited by 18 publications

(27 citation statements)

References 197 publications

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“…Leishmaniasis may present a therapeutic challenge. Sensitivity to treatment differs according to the species of Leishmania (Heras‐Mosteiro et al, ). The patient had initially been treated with pentavalent antimony in Iran without effect.…”

Section: Discussionmentioning

confidence: 99%

Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report

Johansen

Jemec

Fabricius

2019

Dermatologic Therapy

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Leishmaniasis is a vector borne disease transmitted by phlebotomine sandflies. Cutaneous leishmaniasis (CL) predominantly causes skin ulcers but may disseminate. CL may present a therapeutic challenge. The present study reports the case of a 15‐year old boy with CL consisting of a single, ulcer on the leg, resistant to pentavalent antimony, oral fluconazole and topical ketoconazole therapy. Repeated photodynamic therapy using aminolevulinic acid resulted in complete healing of the ulcer, suggesting utility of this approach in resistant cases of CL.

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Section: Discussionmentioning

confidence: 99%

Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report

Johansen

Jemec

Fabricius

2019

Dermatologic Therapy

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“…However, studies on other treatment options for L. tropica are scarce, inconsistent, or inconclusive. 42,43 This refers to topical treatment options, such as paromomycin ointment, TT, CO 2 laser, or cryotherapy, and other systemic treatment options, such as miltefosine, amphotericin B, or itraconazole. Some options seem promising in L. tropica but require more study in larger cohorts.…”

Section: Discussionmentioning

confidence: 99%

Failure of an Innovative Low-Cost, Noninvasive Thermotherapy Device for Treating Cutaneous Leishmaniasis Caused by Leishmania tropica in Pakistan

Kämink

Abdi²,

Kamau

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Abstract.Cutaneous leishmaniasis (CL), a neglected parasitic skin disease, is endemic in Pakistan, where Leishmania tropica and Leishmania major are the causative protozoan species. Standard treatment with antimonial injections is long, painful, and costly; has toxic side effects; and is not always available in public hospitals. Small pilot studies have previously evaluated a low-cost and noninvasive hand-held exothermic crystallization thermotherapy for cutaneous leishmaniasis (HECT-CL) device. We aimed to further establish the effectiveness, safety, and feasibility of HECT-CL in L. tropica. In a prospective observational study, patients with parasitological confirmation of CL were treated using the HECT-CL heat pack for 3 minutes with an initial temperature of 52–53°C for 7 consecutive days. Dried blood spot samples were taken for species identification by polymerase chain reaction (PCR). Effectiveness was assessed by using medical photographs and measurements of the lesion size at baseline and subsequent follow-up visits, for up to 180 days. We intended to enroll 317 patients. The HECT-CL treatment was easy to apply and well tolerated. Species identification demonstrated the presence of L. tropica. Interim analysis of 56 patients showed a failure rate of 91% at follow-up (median 45 days after treatment, interquartile range 30–60 days). Enrollment of patients was prematurely suspended because of futility. This study showed a high failure rate for HECT-CL thermotherapy in this setting. Leishmania tropica is known to be less sensitive to antileishmanial drugs, more temperature-resistant, and spontaneous healing is slower than that in L. major. More research is needed to identify low-cost, effective, and more patient-friendly treatment for L. tropica.

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“…As previously mentioned, paromomycin is often irritant. Cases of erythema, oedema, vesicles, blisters, erosions, folliculitis, itching, burning sensation and pain have been reported. In a Colombian study published in 1998, pruritus and burning sensation occurred in 25% of patients, and vesicular lesions in 15% of them .…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis caused by paromomycin

et al. 2019

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Interventions for Old World cutaneous leishmaniasis

Abstract: Analysis 1.1. Comparison 1 ILMA weekly versus ILMA fortnightly for up to 8 weeks, Outcome 1 Lesions cured. . . Analysis 2.1. Comparison 2 ILMA (every other day) versus IMMA (6 d/

Cited by 18 publications

References 197 publications

Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report

Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report

Failure of an Innovative Low-Cost, Noninvasive Thermotherapy Device for Treating Cutaneous Leishmaniasis Caused by Leishmania tropica in Pakistan

Allergic contact dermatitis caused by paromomycin

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