Interventions for nausea and vomiting in early pregnancy

Jewell, David; Young, Gavin

doi:10.1002/14651858.cd000145

Cited by 193 publications

(120 citation statements)

References 39 publications

(17 reference statements)

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“…Antihistamines are the drugs of choice for nausea and vomiting during pregnancy when simpler medications did not work but were only prescribed by 26 out of 52 of the respondents. In contrast, some prescribed treatments that are harmful or ineffective; three obstetricians use adrenocorticotropin to stop vomiting in early pregnancy despite longstanding evidence that it is ineffective [8,9] and two reported prescribing diethylstilbestrol (which is still available for treatment of breast and prostate cancer) to prevent miscarriage, although it has been known that it is carcinogenic since the late 1960s [10]. All but three respondents prescribed some sort of physical therapy (light, magnetic, electric) during pregnancy.…”

Section: Antenatal Period: Prescribing During Pregnancymentioning

confidence: 99%

“…Others used 14 different infusions, the most popular being vitamin C (20 respondents) and other vitamins (10 respondents), spasmolytics, usually No-shpa (16), Co-carboxylase (15), glucose (13), actovegin (11), methylergonovine and other uterothonics (9). No-shpa or Drotaverine is a poorly evaluated drug produced in Hungary which supposedly eases pain related to contractions and is widely used in the former Soviet Union as a painkiller.…”

Section: Labour and Deliverymentioning

confidence: 99%

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Prescribing in maternity care in Russia: The legacy of Soviet medicine

2008

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Section: Antenatal Period: Prescribing During Pregnancymentioning

confidence: 99%

Section: Labour and Deliverymentioning

confidence: 99%

Prescribing in maternity care in Russia: The legacy of Soviet medicine

2008

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“…It is endemic to East Asia, Azerbaijan, Russia, Armenia, Iran, Turkmenistan, and Afghanistan (10) and mainly contains tannins (11,12), carotenoids, coumarin, glycosides, heterogeneous polysaccharides, pectin (13), and flavonoids (10). Wound healing (14) and antiemetic properties of quince (15), along with its benefits in improving liver function (16) and lowering blood pressure (17), glucose (18), and lipid level (16), have been reported in previous research. According to a preliminary study, micronized flavonoids suppress endometrial prostaglandins and can be effective in the treatment of abnormal uterine bleedings (19).…”

Section: Introductionmentioning

confidence: 92%

Effects of Mefenamic Acid Versus Quince on Menorrhagia and Quality of Life: A Randomized Controlled Trial

Rahi

Mirghafourvand

Mohammad‐Alizadeh‐Charandabi

et al. 2017

Iran Red Crescent Med J

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Objectives: To compare the effects of mefenamic acid versus quince on menorrhagia and quality of life. Methods: This randomized controlled trial was conducted on women with menorrhagia. The participants were allocated into 2 groups through block randomization. The first group (n, 72) received quince pills, while the second group (n, 74) used mefenamic acid pills for 3 consecutive cycles. The participants completed the pictorial blood loss assessment chart (PBAC) before and during the intervention. Moreover, the short-form health survey (SF-36) was completed before and 3 months after the intervention. Results: The mean PBAC scores decreased significantly in both groups. The mean PBAC score in the quince group decreased from 173.6 (SD, 53.8) before the intervention to 116.7 (51.7), 86.4 (43.1), and 68.9 (36.4), respectively in the first, second, and third months after the intervention. The mean PBAC scores in the mefenamic acid group was 176.8 (54.3) at baseline and 106.6 (50.40), 81.6 (38.7), and 63.8 (33.8), respectively in the first, second, and third months after the intervention. There was no significant difference between the groups in terms of the mean PBAC score (P = 0.183). Similarly, after the intervention, there was no significant difference between the groups in terms of physical health (P = 0.476) and mental health (P = 0.572) components of quality of life. Conclusions: Quince pills were as effective as mefenamic acid pills in reducing the intensity of menstrual bleeding. Therefore, they seem to be a proper alternative for mefenamic acid.

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“…[69] bietet die Einnahme von Ingwerextrakten oder -pulver einen populären naturheilkundlichen Therapieansatz mit hoher Akzeptanz [70][71][72][73]. Allerdings sind die optimale Dosis sowie eventuelle Nebenwirkungen nicht vollständig geklärt [74,75]. In der üblichen Dosierung scheint die Anwendung von Ingwer bei Schwangerschaftsübelkeit und -erbrechen jedoch kein Problem darzustellen [49].…”

Section: Alternative Therapieansätzeunclassified

Hyperemesis gravidarum

Böer

Hoopmann

Hübner

et al. 2011

Geburtsh Frauenheilk

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Einleitung ! Die Symptome Übelkeit und Erbrechen sind in bis zu 80 % aller Schwangerschaften nachweisbar und damit insbesondere zwischen der 4. bis 10. Schwangerschaftswoche als physiologisch anzusehen [1]. Da vonseiten der Gesellschaft gegenüber dieser Begleiterscheinung eine hohe Akzeptanz besteht, wird sie in der Regel von der betroffenen Schwangeren weitreichend akzeptiert. Nur in ca. 2 % der Fälle bestehen die Symptome isoliert am Morgen. Meist treten sie über den Tag verteilt auf und sistieren im Allgemeinen ab der 14. SSW [2]. In einer prospektiven Untersuchung an 160 betroffenen Schwangeren waren in der 14. Schwangerschaftswoche 50 % der Frauen, in der 22. SSW über 90 % der Probandinnen beschwerdefrei [3]. In bis zu 20 % aller Schwangerschaften persistiert die Übelkeit über den gesamten Verlauf der Gravidität [1, 4]. Gegenüber der Emesis gravidarum liegt die Inzidenz der Hyperemesis gravidarum (HG), also dem übermäßigen Erbrechen in der Schwangerschaft, weltweit zwischen 0,5-2%. Es bestehen Zusammenfassung ! Circa 80% aller Frauen leiden während der Schwangerschaft an Übelkeit und Erbrechen. In bis zu 20% der Fälle können die Symptome über die gesamte Gravidität beobachtet werden. Die Ursache ist nach heutigem Kenntnisstand multifaktoriell und nicht endgültig geklärt. Die Betroffenen zeigen ein über den Tag hinweg übermäßig häufiges Erbrechen. Die weiteren Beschwerden sind häufig unspezifisch. Für die Diagnose richtungsweisend sind v. a. die Klinik der Patientin und die Ergebnisse der Laboruntersuchung (Elektrolytentgleisung, Hämatokriterhöhung, Ketonurie etc.). Die Behandlung ist symptomatisch. Neben der medikamentösen Therapie (Vitamin B 6 , Antihistaminika, Anticholinergika und andere niedrig dosierte Antiemetika sowie gastrointestinal wirksame Medikamente) haben auch naturheilkundliche Verfahren (Akupunktur, Akupressur, Ingwer etc.) ihren Stellenwert. Darüber hinaus sollte die Indikation zur psychosomatischen und -therapeutischen Begleitbehandlung groß-zügig gestellt werden, da davon auszugehen ist, dass psychologische Faktoren in der Pathogenese eine gewichtige Rolle spielen. Bei ausgeprägtem Verlauf (Hyperemesis Grad II) ist eine stationäre Behandlung indiziert.Abstract ! About 80 % of pregnant women suffer from nausea and vomiting and about 20 % will remain symptomatic throughout the whole course of pregnancy. The origin is not fully clarified and is believed to be multifactorial. The key symptoms that point towards the diagnosis of hyperemesis gravidarum consist of the clinical presentation and changes in the blood and urine analysis (increasing hematocrit, ketonuria, dysbalance of electrolytes, etc.). The treatment is symptomatic and consists of vitamin B 6 , antihistaminics, anticholinergics and other low dosed anti-emetics. Alternative approaches such as acupuncture, acupressure, ginger, etc. also play an important role. As psychological factors may often be of importance, psychosomatic treatment should always be considered. If the clinical symptoms are more pronounced (hyperemesis gravidarum l...

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Interventions for nausea and vomiting in early pregnancy

Cited by 193 publications

References 39 publications

Prescribing in maternity care in Russia: The legacy of Soviet medicine

Prescribing in maternity care in Russia: The legacy of Soviet medicine

Effects of Mefenamic Acid Versus Quince on Menorrhagia and Quality of Life: A Randomized Controlled Trial

Hyperemesis gravidarum

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