Interventions for morphea

Albuquerque, Julia Vajda de; Andriolo, Brenda Ng; Vasconcellos, Monica Ra; Civile, Vinicius Tassoni; Lyddiatt, Anne; Trevisani, Virgínia Fernandes Moça

doi:10.1002/14651858.cd005027.pub5

Cited by 31 publications

(56 citation statements)

References 56 publications

(12 reference statements)

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“…Some therapeutic regimens used in morphea with variable efficacy include systemic steroids, methotrexate, phototherapy, mycophenolate mofetil, hydroxychloroquine, cyclosporine, and abatacept; however, the most effective treatment, especially in more severe types of the disease, is the combination of methotrexate and pulsed corticosteroids (5,6,11).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anxiety and depression in patients with morphea taking immunosuppressive drugs during the COVID-19 pandemic

Dadras

Ahmadzadeh

Younespour

et al. 2020

Journal of Dermatological Treatment

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Background: During the coronavirus disease 2019 (COVID-19) pandemic, individuals especially those with chronic diseases face various problems like psychological distress. Aim: To evaluate anxiety and depression among morphea patients taking immunosuppressants compared with controls during the COVID-19 pandemic. Methods: In this case-control study, electronic data of 42 eligible morphea patients and 42 age-and sex-matched healthy subjects were extracted. All participants were asked about adherence to the health protocols and the symptoms of COVID-19. To investigate anxiety and depression, we provided the participants with an online version of the Hospital Anxiety and Depression Scale (HADS) Questionnaire. In this standard questionnaire, a score ! 11 represents a significant psychological disorder. Results: The two groups did not differ significantly in the mean HADS-Anxiety (HADS-A) and HADS-Depression (HADS-D) scores (p¼ .08 and p¼ .79, respectively). HADS-A and HADS-D scores were ! 11 in 16.67% and 11.90% of the patients, respectively. Among the morphea patients, those with sleeping problems during COVID-19 had a significantly higher mean HADS-D score (p¼ .048). Notably, 21.43% of patients discontinued their treatment due to fear of COVID-19 and experienced disease recurrence. Adherence to health protocols was higher in patients compared with controls. The rate of COVID-19 occurrence was not significantly different between the groups. Conclusions: Although there was no significant difference in anxiety and depression between the groups, it is recommended to provide psychiatric counseling opportunities to morphea patients to improve treatment outcomes during this pandemic.

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Section: Introductionmentioning

confidence: 99%

Evaluation of anxiety and depression in patients with morphea taking immunosuppressive drugs during the COVID-19 pandemic

Dadras

Ahmadzadeh

Younespour

et al. 2020

Journal of Dermatological Treatment

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“…52 A systematic review of 62 pediatric and adult with active morphea showed that MD-UVA1 (50 J/cm 2 ), low dose-UVA1 (LD-UVA1) (20 J/cm 2 ), and NB-UVB five times a week for eight weeks has the same effectiveness. 53 Case reports of three patients with localized scleroderma who received UVA1 with a total dose of 540-1800 J/cm 2 showed improvement of collagen fibers texture with reducing of their size. 54 The Single Hub and Access Point for Pediatric Rheumatology in Europe (SHARE) recommends MD-UVA1 in children with localized scleroderma due to its effectiveness in improving tenderness and reducing skin thickness.…”

Section: Scleroderma (Loe Ii)mentioning

confidence: 97%

Ultraviolet phototherapy for treatment of various dermatoses

Batubara

Paramitha

Pusponegoro

et al. 2021

JMedSci

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Ultraviolet (UV) radiation has been applied to treat many chronic skin diseases. Based on the wavelength, UV radiation consists of three types, namely ultraviolet C (UVC), ultraviolet B (UVB), and ultraviolet A (UVA). The types of UV that are widely used in dermatology are narrowband ultraviolet B (NB-UVB), broadband ultraviolet B (BB-UVB), UVA1, and psoralen combined with UVA (PUVA). The interaction between UV and the skin determines the effectiveness of phototherapy. The biological effects of UV are used in the management of inflammatory skin diseases, malignancies, and various rare dermatoses. Apart from these benefits, UV increases the risk of photoaging and skin cancer. Therefore, further researches are necessary to enhance the effectiveness and safety of phototherapy. This literature review discusses the role of phototherapy in various dermatoses other than psoriasis and vitiligo. ABSTRAKRadiasi sinar ultraviolet (UV) telah digunakan untuk pengobatan penyakit kulit kronik. Berdasarkan panjang gelombangnya, radiasi UV dibedakan dalam tiga jenis yaitu ultraviolet C (UVC), ultraviolet B (UVB), dan ultraviolet A (UVA). Jenis UV yang digunanakan secara luas dalam dematologi adalah narrowband ultraviolet B (NB-UVB), broadbrand ultraviolet B (BB-UVB), UVA1, dan psoralen dikombinasikan dengan UVA (PUVA). Interaksi antara UV dan kulit menentukan efektivitas fototerapi. Efek biologi UV digunakan dalam pengelolaan penyakit kulit inflamasi, malignansi, dan berbagai penyakit kulit yang jarang. Terlepas dari manfaatnya, UV meningkatkan risiko fotoaging dan kanker kulit. Oleh karena itu, penelitian lanjut diperlukan untuk meningkatkan efektivitas dan keamanan fototerapi. Kajian pustaka ini membicarakan peran fototerapi dalam berbagai penyakit kulit selain psoriasis dan vitiligo.

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“…Some environmental factors like silica or organic solvents may play an important role. It may be also triggered by viral or bacterial (Borelia burgdorferi) infections [14].Genetic factors have been also implicated [1]. Some forms of morphea are activated by trauma or associated with an autoimmune process.…”

Section: Etiology and Pathogenesismentioning

confidence: 99%