Interventions for erosive lichen planus affecting mucosal sites

Management of pain in oral lichen planus patients: a comparative pilot study

“…In a prospective study, low-level laser irradiation given to unresponsive OLP patients demonstrated significant decrease in clinical signs and symptoms with no side effects observed (Cafaro et al 2010). Also, 19 females who had OLP in their tongues reported reduction of pain, discomfort, and lesions' size after receiving LLLT (Cheng et al 2012). In another study, more favorable clinical and symptomatic results were achieved in patients receiving LLLT in comparison to those treated with CO2 laser (Agha-Hosseini et al 2012).…”

Management of pain in oral lichen planus patients: a comparative pilot study

“…In a prospective study, low-level laser irradiation given to unresponsive OLP patients demonstrated significant decrease in clinical signs and symptoms with no side effects observed (Cafaro et al 2010). Also, 19 females who had OLP in their tongues reported reduction of pain, discomfort, and lesions' size after receiving LLLT (Cheng et al 2012). In another study, more favorable clinical and symptomatic results were achieved in patients receiving LLLT in comparison to those treated with CO2 laser (Agha-Hosseini et al 2012).…”

Erosive lichen planus: an unmet disease burden

“…Patients are less likely to respond to first line medications, such as a single topical steroid. Recalcitrant disease may require the use of calcineurin inhibitor such as tacrolimus, or systemic immunosuppression, including systemic steroids and/or disease-modifying anti-rheumatic drugs (DMARDS), such as hydroxychloroquine, azathioprine and/or mycophenolate mofetil ( 36 , 37 ). Patients with erosive disease more frequently require systemic immunosuppression, such as a DMARD, or a multi treatment approach, in an attempt to control their disease activity.…”

Different Treatment Modalities of Oral Lichen Planus—A Narrative Review

“…Due to its unknown etiology, the treatment is symptomatic and involves suppressing signs and symptoms of the disease. The lack of convincing evidence on the effectiveness of many therapies, including topical corticosteroids, was noted in a Cochrane systematic review [17]. Upon searching the database, a total of two hundred and twenty articles were identified, addressing the subject of the current therapeutic possibilities of OLP.…”

“…In six studies, patients with a non-erosive form of OLP were also included; however, only patients with erosive OLP were included in this systematic review. In the end, it was not possible to combine the results of the conducted studies, given the mentioned heterogeneity [17]. An update of the mentioned review was published in 2020 and focused on the evidence solely for corticosteroid therapy [123].…”

Management of pain in oral lichen planus patients: a comparative pilot study

“…In a prospective study, low-level laser irradiation given to unresponsive OLP patients demonstrated significant decrease in clinical signs and symptoms with no side effects observed (Cafaro et al 2010). Also, 19 females who had OLP in their tongues reported reduction of pain, discomfort, and lesions' size after receiving LLLT (Cheng et al 2012). In another study, more favorable clinical and symptomatic results were achieved in patients receiving LLLT in comparison to those treated with CO2 laser (Agha-Hosseini et al 2012).…”

Erosive lichen planus: an unmet disease burden

“…Patients are less likely to respond to first line medications, such as a single topical steroid. Recalcitrant disease may require the use of calcineurin inhibitor such as tacrolimus, or systemic immunosuppression, including systemic steroids and/or disease-modifying anti-rheumatic drugs (DMARDS), such as hydroxychloroquine, azathioprine and/or mycophenolate mofetil ( 36 , 37 ). Patients with erosive disease more frequently require systemic immunosuppression, such as a DMARD, or a multi treatment approach, in an attempt to control their disease activity.…”

Different Treatment Modalities of Oral Lichen Planus—A Narrative Review

“…Due to its unknown etiology, the treatment is symptomatic and involves suppressing signs and symptoms of the disease. The lack of convincing evidence on the effectiveness of many therapies, including topical corticosteroids, was noted in a Cochrane systematic review [17]. Upon searching the database, a total of two hundred and twenty articles were identified, addressing the subject of the current therapeutic possibilities of OLP.…”

“…In six studies, patients with a non-erosive form of OLP were also included; however, only patients with erosive OLP were included in this systematic review. In the end, it was not possible to combine the results of the conducted studies, given the mentioned heterogeneity [17]. An update of the mentioned review was published in 2020 and focused on the evidence solely for corticosteroid therapy [123].…”

Management of pain in oral lichen planus patients: a comparative pilot study

“…In a prospective study, low-level laser irradiation given to unresponsive OLP patients demonstrated significant decrease in clinical signs and symptoms with no side effects observed (Cafaro et al 2010). Also, 19 females who had OLP in their tongues reported reduction of pain, discomfort, and lesions' size after receiving LLLT (Cheng et al 2012). In another study, more favorable clinical and symptomatic results were achieved in patients receiving LLLT in comparison to those treated with CO2 laser (Agha-Hosseini et al 2012).…”

Erosive lichen planus: an unmet disease burden

“…Patients are less likely to respond to first line medications, such as a single topical steroid. Recalcitrant disease may require the use of calcineurin inhibitor such as tacrolimus, or systemic immunosuppression, including systemic steroids and/or disease-modifying anti-rheumatic drugs (DMARDS), such as hydroxychloroquine, azathioprine and/or mycophenolate mofetil ( 36 , 37 ). Patients with erosive disease more frequently require systemic immunosuppression, such as a DMARD, or a multi treatment approach, in an attempt to control their disease activity.…”

Different Treatment Modalities of Oral Lichen Planus—A Narrative Review

“…Due to its unknown etiology, the treatment is symptomatic and involves suppressing signs and symptoms of the disease. The lack of convincing evidence on the effectiveness of many therapies, including topical corticosteroids, was noted in a Cochrane systematic review [17]. Upon searching the database, a total of two hundred and twenty articles were identified, addressing the subject of the current therapeutic possibilities of OLP.…”

“…In six studies, patients with a non-erosive form of OLP were also included; however, only patients with erosive OLP were included in this systematic review. In the end, it was not possible to combine the results of the conducted studies, given the mentioned heterogeneity [17]. An update of the mentioned review was published in 2020 and focused on the evidence solely for corticosteroid therapy [123].…”