Interventions for atrophic rhinitis

Mishra, Anupam; Kawatra, Rahul; Gola, Manoj

doi:10.1002/14651858.cd008280

Cited by 5 publications

(12 citation statements)

References 18 publications

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“…The treatment of atrophic rhinitis has 4 main approaches: reduce the nasal cavity with various substances and implants, promote the regeneration of normal mucosa using a classical operation or modified Young’s operation [1], lubricate the nasal mucosa, or improve the vascularity of the nasal cavity [1]. Many other treatment approaches have been attempted, including nasal irrigation and flushing, glucose-glycerine nasal drops, liquid paraffin, estradiol in arachis oil, anti-ozaena solution, antibiotics, iron, zinc, protein, vitamin supplements, vasodilators, prostheses, vaccines, placental extract, or acetylcholine with or without pilocarpine.…”

Section: Discussionmentioning

confidence: 99%

“…Many other treatment approaches have been attempted, including nasal irrigation and flushing, glucose-glycerine nasal drops, liquid paraffin, estradiol in arachis oil, anti-ozaena solution, antibiotics, iron, zinc, protein, vitamin supplements, vasodilators, prostheses, vaccines, placental extract, or acetylcholine with or without pilocarpine. However, these methods have varied effectiveness [1]. In the clinic, nasal irrigation with nasal spray is the most common method to manage atrophic rhinitis symptoms, as it hydrates the nasal mucosa and prevents crust formation [12].…”

Section: Discussionmentioning

confidence: 99%

“…Atrophic rhinitis is a chronic condition characterized by progressive atrophy of the nasal mucosa and underlying bone. It leads to the formation of nasal crusts, fetor, nasal obstruction, epistaxis, olfactory disturbances, secondary infection, nasal deformity, and, rarely, intracranial spread [1]. Atrophic rhinitis can be classified as either primary or secondary to a predisposing condition or event.…”

Section: Introductionmentioning

confidence: 99%

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Platelet-Rich Plasma Injection in Patients with Atrophic Rhinitis

Kim

Lee

et al. 2021

ORL

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Objective: To investigate the effect of platelet-rich plasma (PRP) injection in patients with atrophic rhinitis. Methods: Prepared PRP was injected into the inferior turbinate bilaterally, and nasal bacterial cultures were conducted. Improvement of symptoms was assessed with the Nasal Obstruction Symptom Evaluation (NOSE) and the Sino-Nasal Outcome Test-22 (SNOT-22). Nasal mucociliary clearance was assessed using the saccharin transit time (STT). Results: In the PRP-injected group (group A), NOSE (throughout the study) and SNOT-22 (1 month after injection) scores were significantly decreased during the study. However, the saline spray group (group B) showed no significant nasal symptom improvement during the study period. In group A, the STT was improved until 3 months after the injection. In contrast, group B showed STT improvement after 2 months that was maintained throughout the study. Conclusion: PRP injections can improve nasal symptoms and nasal mucociliary function in patients with atrophic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet-Rich Plasma Injection in Patients with Atrophic Rhinitis

Kim

Lee

et al. 2021

ORL

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“…Fisher's exact test was used to determine whether there was a difference in administering NSI between physicians and pharmacists as well as other subgroups and categories. The continuous variables were [8] May be beneficial, no recommendation can be made Low or very low Chronic sinusitis [7] May be beneficial, no recommendation can be made Low or very low Atrophic rhinitis [10] No recommendation can be made Asthma None exist Post-operative care after functional endoscopic sinus surgery None exist Regular cleaning after functional endoscopic sinus surgery None exist described as median values and interquartile ranges (IQR). Differences between the two groups for continuous variables were calculated with independent samples Mann-Whitney U test.…”

Section: Discussionmentioning

confidence: 99%

Nasal saline irrigation: prescribing habits and attitudes of physicians and pharmacists

Tapiala

Hyvärinen

Toppila‐Salmi

et al. 2021

Scandinavian Journal of Primary Health Care

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Objectives: To explore the opinions, the usage and the patient education given on nasal saline irrigation by physicians and pharmaceutical personnel working in Finland. Design: An internet-based survey with predetermined, multiple-choice answers. Setting: Primary care centres, occupational health centres and private care centres in Eastern Finland as well as pharmacies in Finland. Main outcome measures: Healthcare professionals views, practice and general knowledge of nasal irrigation for sinonasal symptoms and conditions. Results: We received 595 completed surveys (110 physicians, 485 pharmacists). The majority of the respondents recommended nasal saline irrigation for their patients either as a symptomatic treatment (98.0%) or to treat a specific condition (97.5%) such as acute rhinosinusitis, chronic rhinosinusitis and allergic rhinitis. Nasal saline irrigation was also often recommended as a prophylaxis for airway-infections (71.9%) and to enhance the health of the nasal mucosa (58.2%). In general, the possible adverse effects were recognised poorly by both professions. There was a clear difference between the two professions, as physicians were more conservative in recommending nasal saline irrigation and recognised possible adverse effects, such as epistaxis, pain, and dryness of the nose, better (75% vs. 59%, p ¼ 0.002). Conclusions: Nasal saline irrigation seems to be a popular treatment recommended by many health care professionals in Finland. Physicians and pharmaceutical personnel had variable opinions on the indications, utility and risks of nasal saline irrigation. There are also clear differences between physicians and pharmaceutical personnel's practices. There is a need to better educate professionals about nasal saline irrigation and to further study whether nasal saline irrigation is efficient and safe option for the different common sinonasal conditions. KEY POINTS Little information is available on how physicians and pharmacists recommend nasal saline irrigation as a symptomatic treatment. Physicians and pharmacists seem to have variable opinions about the indications, utility and safety of nasal saline irrigation. The patient education given is in general very heterogenous. Both professions require more education to ensure that the usage remains as safe as possible for the patient.

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“…1 A 2012 review by Mishra and others tried to assess the effectiveness of different treatments by comparing their outcomes and long-term benefits, but could not find randomized controlled studies that met their inclusion criteria. 13 Many authors argue that ozena is not curable and the aim of treatment is simply abatement of symptoms. No one treatment modality, however, can address all symptom causes.…”

Section: Discussionmentioning

confidence: 99%

Ozena in Immigrants of Differing Backgrounds

Yelenich-Huss

Boyer

Alpern

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Ozena, or atrophic rhinitis, is a chronic nasal process seen in Africa, India, and the Middle East. It is marked by the triad of fetid nasal discharge, crusting, and atrophy, and is often associated with Klebsiella infection. We present cases of ozena with nasal Klebsiella in three unrelated patients, including two east African children and one Saudi adult. All three patients grew Klebsiella species in culture and required prolonged treatment with multiple methodologies, including antibiotics, saline rinses, and surgical debridement. They differed greatly in time from presentation to diagnosis, and demonstrated various stages of the disease process. Ozena is rarely seen in the United States, and when it is seen, it is often misdiagnosed. Lack of prompt, adequate treatment can lead to long-term sequelae such as obliteration of nasal architecture, anosmia, sinus and skull base destruction, and social disenfranchisement due to the extreme foul smell of the nasal discharge. Clinicians should maintain a high index of suspicion for primary atrophic rhinitis when presented with its classic symptoms. Culture-directed and prolonged therapy with appropriate follow-up is a necessary component of a successful treatment plan.

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Interventions for atrophic rhinitis

Cited by 5 publications

References 18 publications

Platelet-Rich Plasma Injection in Patients with Atrophic Rhinitis

Platelet-Rich Plasma Injection in Patients with Atrophic Rhinitis

Nasal saline irrigation: prescribing habits and attitudes of physicians and pharmacists

Ozena in Immigrants of Differing Backgrounds

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