2008
DOI: 10.1002/14651858.cd004413.pub2
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Interventions for alopecia areata

Abstract: Few treatments for alopecia areata have been well evaluated in randomised trials. We found no RCTs on the use of diphencyprone, dinitrochlorobenzene, intralesional corticosteroids or dithranol although they are commonly used for the treatment of alopecia areata. Similarly although topical steroids and minoxidil are widely prescribed and appear to be safe, there is no convincing evidence that they are beneficial in the long-term. Most trials have been reported poorly and are so small that any important clinical… Show more

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Cited by 164 publications
(147 citation statements)
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“…Persistent moderate-to-severe AA causes significant disfigurement and psychological distress in affected individuals (3). In clinical practice, there are no evidence-based treatments for AA (4), yet various treatments are offered, most commonly topical and intralesional steroids, which have limited efficacy.…”
Section: Introductionmentioning
confidence: 99%
“…Persistent moderate-to-severe AA causes significant disfigurement and psychological distress in affected individuals (3). In clinical practice, there are no evidence-based treatments for AA (4), yet various treatments are offered, most commonly topical and intralesional steroids, which have limited efficacy.…”
Section: Introductionmentioning
confidence: 99%
“…Midpotent and potent topical corticosteroids in forms of lotions, creams, and ointments are widely used in spite of the fact that evidence of their effectiveness is limited [42,43]. In a double-blind placebo-controlled study, rate of complete hair growth was not statistically significant with 12 weeks use of 0.25% desoximetasone cream, twice daily, when compared with placebo [44].…”
Section: Topical Corticosteroidsmentioning
confidence: 98%
“…Curative therapy does not exist, and there is a paucity of well-conducted, long-term, controlled trials evaluating the efficacy of therapy and its effect on the quality of life. 20 Poor prognostic factors include bald patches persisting for more than 1 year, onset or aggravation of hair loss before puberty, positive family history of AA, ophiasis pattern of involvement, associated nail changes, atopy, autoimmune disorders, and Down syndrome.…”
Section: Treatmentmentioning
confidence: 99%
“…20 Spontaneous remission occurs in 80% of patients with AA within 1 year, and not all patients require intense therapy. Therefore, watchful observation is also a therapeutic option.…”
mentioning
confidence: 99%