Interventional Therapies for Osteoarthritis: An Update

Beckmann, Nicholas M.; Villamaria, Emma

doi:10.2214/ajr.22.27548

Cited by 9 publications

(5 citation statements)

References 83 publications

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“…GAE has been shown to be less expensive than cyclooxygenase-2-selective drugs and hyaluronic acid injections, but more costly in comparison with oral NSAIDs 51,55 . The estimated cost of GAE is approximately $3,095.75, which can vary depending on the embolizing agents used 56,57 .…”

Section: Clinical Outcomes and Efficacy Of Gaementioning

confidence: 99%

Genicular Artery Embolization for Knee Osteoarthritis

Poursalehian,

Bhia,

Ayati Firoozabadi

et al. 2023

JBJS Reviews

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» Genicular artery embolization (GAE) is a promising treatment option for patients with knee osteoarthritis who are unresponsive to nonsurgical treatments and not yet candidates for surgery.» Current evidence supports the effectiveness of GAE in reducing pain and synovitis, with few reported major adverse events.» The cost-effectiveness and long-term results of GAE compared with other treatment options require further investigation.» Limitations of existing studies include small sample sizes, single-center trials, and lack of comparison between embolic agents and other treatments.» Future research should focus on larger, multicenter trials with longer follow-up periods and head-to-head comparisons with alternative treatment modalities to establish the role of GAE in the management of knee osteoarthritis.

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Section: Clinical Outcomes and Efficacy Of Gaementioning

confidence: 99%

Genicular Artery Embolization for Knee Osteoarthritis

Poursalehian,

Bhia,

Ayati Firoozabadi

et al. 2023

JBJS Reviews

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“…Statistically, OA affects over 520 million individuals globally ( 3 ). with its prevalence escalating alongside population aging, significantly impairing patient quality of life ( 4 ). The etiology of OA remains elusive, with studies suggesting its association with factors like genetic variation, mechanical damage, immune inflammatory response, and metabolic irregularities ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

The causal effect of cytokine cycling levels on osteoarthritis: a bidirectional Mendelian randomized study

Jiang,

Cai,

Yao

et al. 2024

Front. Immunol.

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ObjectiveOsteoarthritis (OA) is the most prevalent joint disease globally, serving as a primary cause of pain and disability. However, the pathological processes underlying OA remain incompletely understood. Several studies have noted an association between cytokines and OA, yet the causal link between them remains ambiguous. This study aims to identify cytokines potentially causally related to OA using Mendelian randomization (MR) analysis, informing early clinical diagnosis and treatment decisions.MethodsWe conducted a genome-wide association study (GWAS) on 12 OA traits involving 177,517 cases and 649,173 controls from 9 international cohorts. For discovery MR analysis, we used 103 cytokines from two European populations as instrumental variables (IVs). Concurrently, another European population OA GWAS database (36,185 cases and 135,185 controls) was used to replicate MR analysis, employing the inverse variance weighted (IVW) method as the primary analytic approach. Additional methods tested included MR Egger, Weighted median, and Weighted mode. We merged the MR findings through meta-analysis. Heterogeneity testing, level pleiotropy testing (MR Egger intercept test and MRPRESSO), and sensitivity analysis via Leave One Out (LOO) were conducted to verify result robustness. Lastly, reverse MR analysis was performed.ResultsThe meta-analysis merger revealed a correlation between CX3CL1 cycle levels and increased OA risk (OR=1.070, 95% CI: 1.040-1.110; P<0.010). We also observed associations between MCP4 (OR=0.930, 95% CI: 0.890-0.970; P<0.010) and CCL25 (OR=0.930, 95% CI: 0.890-0.970; P<0.010) with reduced OA risk. The sensitivity analysis results corroborate the robustness of these findings.ConclusionOur MR analysis indicates a potential causal relationship between CX3CL1, MCP4, CCL25, and OA risk changes. Further research is warranted to explore the influence of cytokines on OA development.

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“…Osteoarthritis (OA) is a common and complex degenerative joint disease worldwide, with chronic in ammation of joints and their appendages leading to pain, swelling, limited functional activity, and even deformities being the main clinical manifestation [1][2][3]. With the aging of the global population, the incidence rate of OA is increasing year by year, which seriously affects the quality of life of patients and brings huge economic burden to society [4][5][6]. At present, the pathogenesis of OA is not clear, but it is known that factors such as obesity, trauma, and lifestyle are all risk factors for the onset of OA [7][8][9], but even if these risk factors are avoided, the incidence rate of OA is still high.…”

Section: Introductionmentioning

confidence: 99%

The causal impact of bioavailable testosterone levels on osteoarthritis: a bidirectional Mendelian randomized study Running Title: Causality of testosterone on OA in bidirectional MR study

Jiang,

Yao,

Yang

et al. 2024

Preprint

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Background: It has been shown that low testosterone levels are associated with the development of osteoarthritis (OA). In our study, we aimed to investigate a bidirectional causal relationship between bioavailable testosterone levels and OA using Mendelian randomization (MR) analysis. Methods: In our study, the datasets from publicly available genome-wide association study (GWAS) were adopted, including the OA-related dataset (ukb-b-14486) and the bioavailable testosterone levels-related dataset (ebi-a-GCST90012104). In total, five methods were utilized, namely MR Egger, Weighted median, Inverse variance weighted (IVW), Simple mode, and Weighted mode. Among them, IVW was the main analytical method. Additionally, the sensitivity analysis was carried out through the heterogeneity test, the horizontal pleiotropy test, and the Leave-One-Out (LOO) method. Results: The result of forward MR analysis demonstrated that bioavailable testosterone levels were considerably relevant to OA, and were a risk factor for OA (OR = 1.009, 95% CI: 1.001-1.017, P = 0.020). However, through reverse MR analysis, we did not find a causal relationship between OA and bioavailable testosterone levels. Moreover, the results of the sensitivity analysis suggested that our results were reliable. Conclusion: The results of our study supported a causal relationship between bioavailable testosterone levels and OA.

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Interventional Therapies for Osteoarthritis: An Update

Cited by 9 publications

References 83 publications

Genicular Artery Embolization for Knee Osteoarthritis

Genicular Artery Embolization for Knee Osteoarthritis

The causal effect of cytokine cycling levels on osteoarthritis: a bidirectional Mendelian randomized study

The causal impact of bioavailable testosterone levels on osteoarthritis: a bidirectional Mendelian randomized study Running Title: Causality of testosterone on OA in bidirectional MR study

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