Interventional Photothermal Therapy Enhanced Brachytherapy: A New Strategy to Fight Deep Pancreatic Cancer

Zhang, Fengrong; Han, Xianlin; Hu, Yibing; Wang, Shunhao; Liu, Shuang; Pan, Xueting; Wang, Hongyu; Ma, Junjie; Wang, Weiwei; Li, Shanshan; Qu, Wu; Shen, Heyun; Yu, Xiaoling; Yuan, Qipeng; Liu, Huiyu

doi:10.1002/advs.201801507

Cited by 54 publications

(36 citation statements)

References 38 publications

(43 reference statements)

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“…Thez eta potential of MYR@Liposome decreased to À1.23 mV after coating with gold particles ( Figure S2). Furthermore,t he photothermal conversion efficiencies (h)ofHGNs and MYR@HGNs were determined to be 26.9 % [14] and 22.8 %( Figure S6), respectively,h igher than many other reported gold nanocrystals (e.g.,g old nanoshells (22.2 %), [16] gold complexes (5.2 %), [17] and gold nanorods (22.1 %)). [15] Element mapping and energy-dispersive X-ray spectroscopy (EDS) spectrum of MYR@HGNs indicated that carbon, calcium, magnesium, gold, nitrogen, oxygen, and phosphorus were homogeneously distributed in the particles,r epresenting the presence of MYR, liposomes, and gold nanoparticles (Figure 1c and Figure S3).…”

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confidence: 89%

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Activation of Prodrugs by NIR‐Triggered Release of Exogenous Enzymes for Locoregional Chemo‐photothermal Therapy

et al. 2019

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Enzymes have been used to direct the conversion of prodrugs in cancer therapy. However,non-specific distribution of endogenous enzymes seriously hinders their bioapplications. Herein, we developed an ear-infrared-triggered locoregional chemo-photothermal therapybased on the exogenous enzyme delivery and remolded tumor mivroenvironment. The catalytic efficiency of enzymes was enhanced by the hyperthermia, and the therapeutic efficacy of photothermal therapy( PTT) was improved owingt ot he inhibition of heat shock protein 90 by chemotherapeutics.T he locoregional chemo-phototherapy achieved ao ne-time successful cure in 4T1 tumor-bearing mice model. Thus,amutually reinforcing feedbackl oop between PTT and chemotherapyc an be initiated by the irradiation, whichh olds apromising future in cancer therapy.

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confidence: 89%

“…[14] Briefly,MYR was encapsulated inside the aqueous cavity of liposomes by the lipid film hydration method (denoted as MYR@Liposome). TheM YR delivery system based on HGNs (MYR@HGNs) was synthesized through an in situ reduction strategy according to our previous work with as light modification.…”

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confidence: 99%

Activation of Prodrugs by NIR‐Triggered Release of Exogenous Enzymes for Locoregional Chemo‐photothermal Therapy

et al. 2019

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“…Zhang et al developed an interventional photothermal-brachytherapy (IPT-BT) strategy to fight deep pancreatic cancer, and the results showed that a high TIR of 96.6% is achieved in SW1990 orthotopic pancreatic tumor-bearing mice by HGN-mediated IPT-BT synergistic therapy. 52 To improve the treatment effect of VX2 hepatic carcinoma, transcatheter intra-arterial infusion combined with IPTT was applied in our study. Furthermore, Bi-Ln NPs with high photothermal conversion efficiency were employed as PTAs.…”

Section: Histological and Immunohistochemical Assaysmentioning

confidence: 99%

<p>Transcatheter Intra-Arterial Infusion Combined with Interventional Photothermal Therapy for the Treatment of Hepatocellular Carcinoma</p>

Zhou

Ling

Cao

et al. 2020

IJN

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Background: Photothermal therapy (PTT) has great potential application in the treatment of tumors. However, due to the low penetration of near-infrared light (NIR) and the low concentration of nanomaterials in the tumor site, the application of PTT has been limited. Purpose: The objective of this study was to investigate the therapeutic effect of transcatheter intra-arterial infusion of lecithin-modified Bi nanoparticles (Bi-Ln NPs) combined with interventional PTT (IPTT) on hepatocellular carcinoma. Methods: Bi-Ln NPs were prepared by emulsifying the hydrophobic Bi nanoparticles and lecithin, and the photothermal conversion and cytotoxicity of Bi-Ln NPs were then measured by infrared imaging and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, respectively. Twenty-four VX2 hepatic carcinoma rabbits were randomly divided into four groups. Rabbits in group A received Bi-Ln NPs by intra-arterial infusion and NIR laser treatment (IA Bi-Ln NPs + Laser), group B received Bi-Ln NPs by intravenous infusion and NIR laser treatment (IV Bi-Ln NPs + Laser), group C received PBS (phosphate buffer saline) via intra-arterial infusion with NIR laser treatment (IA PBS + Laser), group D received PBS via intra-arterial infusion (IA PBS). Transcatheter intra-arterial infusion was conducted by superselective intubation under digital subtraction angiography (DSA) guidance. IPTT was performed by introducing an NIR optical fiber access to the rabbit VX2 hepatic carcinoma under real-time ultrasound guidance. Magnetic resonance imaging (MRI) was performed to evaluate the tumor size. Hematoxylin and eosin (H&E) stain and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) were conducted 7 days after treatment to evaluate the necrosis rate and viability of tumor, respectively. Results: The Bi-Ln NPs have the advantages of good biological compatibility and high photothermal conversion efficiency. Minimally invasive transcatheter intra-arterial infusion can markedly increase the concentration of Bi-Ln NPs in tumor tissues. IPTT can contribute to the significant improvement in the photothermal efficiency of Bi-Ln NPs. Compared to other groups, the group of IA Bi-Ln NPs + Laser showed a significantly higher tumor inhibition rate (TIR) of 93.38 ± 19.57%, a higher tumor necrosis rate of 83.12 ± 8.02%, and a higher apoptosis rate of (43.26 ± 10.65%) after treatment. Conclusion: Transcatheter intra-arterial infusion combined with interventional PTT (IPTT) is safe and effective in eradicating tumor cells and inhibiting tumor growth and may provide a novel and valuable choice for the treatment of hepatocellular carcinoma in the future.

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“…TheM YR delivery system based on HGNs (MYR@HGNs) was synthesized through an in situ reduction strategy according to our previous work with as light modification. [14] Briefly,MYR was encapsulated inside the aqueous cavity of liposomes by the lipid film hydration method (denoted as MYR@Liposome). Theo btained particles were further coated with gold nanoparticles to yield MYR@HGNs.…”

mentioning

confidence: 99%

“…This was also shown by the concentration-and time-dependent temperature increase of HGN dispersions (Figure 1e and Figure S5). Furthermore,t he photothermal conversion efficiencies (h)ofHGNs and MYR@HGNs were determined to be 26.9 % [14] and 22.8 %( Figure S6), respectively,h igher than many other reported gold nanocrystals (e.g.,g old nanoshells (22.2 %), [16] gold complexes (5.2 %), [17] and gold nanorods (22.1 %)). [18] TheN IR-triggered MYR efficient release is the prerequisite for the subsequent activation of GRE.…”

mentioning

confidence: 99%

Activation of Prodrugs by NIR‐Triggered Release of Exogenous Enzymes for Locoregional Chemo‐photothermal Therapy

et al. 2019

Self Cite

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Enzymes have been used to direct the conversion of prodrugs in cancer therapy. However, non‐specific distribution of endogenous enzymes seriously hinders their bioapplications. Herein, we developed a near‐infrared‐triggered locoregional chemo‐photothermal therapy based on the exogenous enzyme delivery and remolded tumor mivroenvironment. The catalytic efficiency of enzymes was enhanced by the hyperthermia, and the therapeutic efficacy of photothermal therapy (PTT) was improved owing to the inhibition of heat shock protein 90 by chemotherapeutics. The locoregional chemo‐phototherapy achieved a one‐time successful cure in 4T1 tumor‐bearing mice model. Thus, a mutually reinforcing feedback loop between PTT and chemotherapy can be initiated by the irradiation, which holds a promising future in cancer therapy.

show abstract

Interventional Photothermal Therapy Enhanced Brachytherapy: A New Strategy to Fight Deep Pancreatic Cancer

Cited by 54 publications

References 38 publications

Activation of Prodrugs by NIR‐Triggered Release of Exogenous Enzymes for Locoregional Chemo‐photothermal Therapy

Activation of Prodrugs by NIR‐Triggered Release of Exogenous Enzymes for Locoregional Chemo‐photothermal Therapy

<p>Transcatheter Intra-Arterial Infusion Combined with Interventional Photothermal Therapy for the Treatment of Hepatocellular Carcinoma</p>

Activation of Prodrugs by NIR‐Triggered Release of Exogenous Enzymes for Locoregional Chemo‐photothermal Therapy

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